Bio 131- Exam 1- Part 1

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  1. what are the 4 main types of tissue in the body
    • Muscle
    • Nervous 
    • epithelial 
    • connective
  2. which 2 of the 4 types of tissue are excitable?

    excitable- muscle and nervous 

    nonexcitable- epithelial and connective
  3. what makes a tissue excitable?
    a tissues ability to generate and respond to electrical signals
  4. what is the most abundant tissue in the body
  5. what are cells linked by

    think about the types
    cell junctions

    • Gap junctions-simplest for fast cell to cell communication (liver, pancreas, ovaries, etc)
    • Tight junctions- restrict movement between the cells that they link (intestinal tract, kidneys, etc)
    • Anchoring junctions- attach cells together
  6. how much of the body weight is water? 

    is 2/3 of that water in the ECF or the ICF? 

    What separates the two?


    selectively permeable plasma membrane
  7. In the 1/3 of body's water in the ECF how much of it is interstitial fluid and how much is plasma? 

    what separates the two?
    80% is interstitial fluid, 20% is plasma

    separated by a blood vessel wall
  8. What ions are usually found in the ICF? ECF? 

    more? less?
    ICF: K+, Pr-, Na+, Cl-, Ca+

    ECF: Na+, Cl-, Ca++, K+, Pr-
  9. What is homeostasis?

    Where is this goal taking place?
    keeping a relatively stable internal environment even when the external environment changes

    the goal is to keep the ECF regulated and maintained
  10. What are some regulation variables for homeostasis?
    temperature, PH, gases, nutrients, electrolytes, wastes, blood, pressure, etc.
  11. when variables are maintained within very narrow limits, what are those variables called?
    set points
  12. what detects the changes in set points and regulated variables? 

    what do they do? what are the 2 types

    • they create feedback loops
    • positive and negative
  13. what is negative feedback? 

    what are the 2 types? explain each
    Negative feedback: makes a change in the opposite direction from which the original disturbance came to bring it back to a normal level. 

    extrinsic: central nervous system or endocrine system 

    intrinsic: occurs when a cell/tissue detects a chance in the environment and responds
  14. what is positive feedback and does it happen often?
    NO, it is very rare. it pushes variables awar from their set point moving it away from homeostasis
  15. functionally, what are the 3 fluid compartments of the body
    the ICF, ECF, and cell membrane
  16. what is the 4 main purposes of the cell membrane
    • 1. to be a physical barrier between the ICF and ECF
    • 2. to control exits and entries 
    • 3. to communicate between the cell and its environment 
    • 4. provides structural support
  17. what are cell/plasma membranes primarily made up of? which is more abundant (there are 3 main)


    what is there also a little bit of
    lipids and proteins

    • Lipids: most abundant, acts as a barrier called phospholipids. the polar hydrophilic heads are on the outside and the fatty acid, nonpolar tails are on the inside 
    • -some cholesterol 

    Proteins: act as transporters via channels that connect with ICF and ECF by different types of gates and via carriers that never connect with the ICF nor ECF, instead they undergo confirmational changes

    Carbohydrates: small amounts found on ECF for cells to use as identification markers
  18. What are characteristics of the cell membrane 

    what is it permeable to, and not permeable to?
    • freely permeable: 
    • water, lipid soluble substances, smaller substances 

    • not freely permeable to: 
    • larger substances, charged/polar particles
  19. what are the 3 types of transport across the cell membrane?
    Passive transport

    Active transport

    Vesicular transport
  20. what are the 2 gradients that happen by passive transport? 

    explain each, what causes them?

    What else is considered passive transport?
    • 1. concentration gradient- difference in concen. between the ICF and ECF. 
    • It goes from high to low concentration, allowed by Brownian motion
    • Brownian motion: all substances are in constant motion above 0 degrees Kelvin

    • 2. Electrical gradient- difference in charge between 2 areas
    • -like charges repel
    • -opposite charges attract

  21. What is a cell at rest? 

    what is resting membrane potential?
    A cell at rest is negative on the inside of the ICF and positive in the ECF 

    charge across a membrane for a cell at rest
  22. Diffusion characteristics

    what are the 2 types?

    • -passive
    • -can happen down a concen. gradient of an electrical gradient 

    • 1. simple- non-mediated, can move through a channel or lipid bilayer on its own 
    • 2. facilitated-mediated because it needs a carrier
    • -specificity
    • -competitive (and inhibitor)
    • -saturation
  23. when does net movement stop? 

    what makes it faster? what law is this?
    when it reached dynamic equilibium 

    • faster:
    • higher temp
    • less distance
    • higher concentration gradients
    • more lipid soluble molecules
    • more membrane permeability (surface area)
    • ficks law of diffusion
  24. What are characteristics of active transport? 

    what 2 kinds are there?
    requires energy input, moves substances across a concentration gradient, always mediated (with a carrier)

    • primary- uses ATP as ATPases (sodium potassium pump) pumps in 2 K+ while pumping out 3 Na+
    • -is considered electrogenic because it causes a charge 

    secondary-uses kinetic energy stored in the concentration gradient. When Na+ moved down its concentration gradient it can take Glucose with it (think of the lock and key model. Na+ can change the lock's confirmation for different transporters). 

  25. What is vesicular transport? 

    2 main types
    vesicles are created when there are too many big particles, to move in and out of the cell

    Endocytosis- membrane engulfs particle and forms a vesicle to bring it inside of the cell

    Exocytosis- extracellular vesicles fuse with the membrane to release contents to the outside
  26. What is osmosis
    the movement of water across a cell membrane in response to the solute concentration gradient
  27. what is osmotic pressure
    the pressure on a piston that exactly opposes the osmotic movement of water into compartment B
  28. what is iso, hypo, and hyper osmotic
    • isosmotic- if the is the same number of solutes on the inside and outside of the cell 
    • hyperosmotic- there are more solutes on the outside of the cell than the inside of the cell 
    • hyposmotic- there are more solutes inside the cell than outside the cell
  29. what is iso, hypo, and hyper tonic
    • isotonic- if the cell does not change in size when places in water
    • hypotonic- if the cell swells or lyses when placed in water
    • hypertonic- if the cell shrinks and loses water
  30. osmolarity vs tonicity
    osmolarity is referring to the number of particles inside or outside of the cell (osmoles of solute per kilogram of water)

    tonicity how the solution effects the cell volume or shape of the ell
  31. what is crenation?
    when a cell is hypertonic, it shrinks and gets the ridges along its edges
  32. what is lysing?
    when a cell is hypotonic and swells, but swells too much and bursts
  33. what is resting membrane potential
    the potential at which the membrane stabilizes

    its the difference in charge across the cell membrane
  34. describe a cell at rest

    what ion is it most permeable to? why?
    Negative charge on the inside of the cell, positive charge on the outside of the cell


    K+ because of K+ leak channels
  35. membrane potential
    the relative measurement of the electrical gradient between the ICF and the ECF

    (set the ECF to 0)
Card Set:
Bio 131- Exam 1- Part 1
2015-10-01 04:31:19
systemic physiology

body organization homeostasis membrane transport
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