Card Set Information
Category of Multiple Myeloma
Primary, marrow, malignant
#1 MC malignant bone tumor
What type of cells is multiple myeloma composed of?
Plasma cells => B cells
MC structure in bone for multiple myeloma to be?
MC bone region for multiple myeloma to be?
Common sites for multiple myeloma to occur
Spine- lower thoracic or lumbar; typically in body, not in posterior arch
MULTICENTRIC- multiple bones, multiple areas
Typical age that multiple myelomas occur at
Over 40 yoa
50-75 yoa- 75%
5th to 7th decade
Is there pain associated with multiple myeloma?
Deep bone pain- aggravated by exercise & weight bearing, better at night, worse at day
Low back pain
4 abnormalities associated with multiple myeloma
Deossification of red marrow bones
Abnormal serum & urinary proteins
Symptoms of anemia due to multiple myeloma
Nothing wrong with RBC
Complications of abnormal serum & urinary proteins associated with multiple myeloma
Marrow replaced with cancer cells
See spike in electrophoresis
Monoclonal gammopathy=> one group of same gamma globulin cells without antigenic stimulus
Confirmed with bone marrow biopsy
Complications of renal disease associated with multiple myeloma
Bence Jones protein clogs kidney
Survival rate for multiple myeloma patients
30 months- death due to renal failure
Why is plain film important for the determination of multiple myeloma?
Because MM is negative on bone scan
Size of multiple myelomas
Vary in size, but less than 2 cm
Appearance of multiple myeloma
Osteoporosis- thinning of cortex
Uniform vertebral collapse
Well defined margin
No sclerosis to margin
Compression fractures present
4 presentations of osteolytic defects associated with multiple myeloma
What is the classical presentation for MM
Punched out lesion
What is myelomatosis associated w/ MM
Only exhibit loss of bone density
May want to test person exhibiting oseteoporosis for MM- electrophoresis, bone biopsy, show up with compression fractures
What is a plasmacytoma associated w/ MM
Localized subacute geographic lesion
What is an extraosseous osteolytic defect associated w/ MM
External to bone marrow & appears in nasopharynx
Dysphagia, mouth breathing
What is the differential for multiple myeloma?
Lytic osteosarcoma- not usually in spine & younger age
Osteomyelitis- more diaphyseal for infection
Ewing's Sarcoma- feel bad & not usually in spine
Non-Hodgkin's Lymphoma- feels ok
Lytic metastasis- in posterior arch of spine
What is solitary plasmacytoma?
More localized, low-grade form of MM
Can become MM
What are common sites for solitary plasmacytoma?
What is the size of a solitary plasmacytoma?
occupies space >2 cm
Is there pain with solitary plasmacytoma
What is the appearance of a solitary plasmacytoma?