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neutrophil
phagocytize bacteria, 50-70%
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eosinophil
kill parasitic worms; complex role in allergy and asthma, 2-4%
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basophil
release histamine and other mediators of inflammation; contain heparin, an anticoagulant, less than 1%
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lymphocyte
mount immune response by direct cell attack or via antibodies, 25% or more
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monocyte
phagocytosis; develop into marcophages in tissues, 3-8%
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differential WBC counts
100 WBCs are counted and classified according to type, and any abnormality of significant elevation in percentages of WBC types may indicate a problem or the source of pathology.
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cause of high neutrophil count
- an acute infection (especially bacterial)
- acute stresseclampsia (complication of pregnancy)
- inflammation (e.g. inflammatory bowel disease or rheumatoid arthritis)
- tissue injury due to traumachronic leukemia
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cause of low neutrophil count
- aplastic anemia (a decrease in the number of blood cells produced by your bone marrow)
- been undergoing chemotherapy treatments
- a severe or widespread bacterial or viral infection
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cause of high lymphocyte count
- a chronic bacterial infection
- hepatitis
- multiple myeloma (cancer of the cells in your bone marrow)
- a viral infection (e.g. mononucleosis, mumps, or measles)
- lymphocytic leukemia
- lymphoma (a white blood cell cancer that originates in your lymph nodes)
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cause of low lymphocyte count
- bone marrow damage due to chemotherapy or radiation treatments
- HIV, tuberculosis, or hepatitis infection
- leukemia
- a severe infection (e.g. sepsis)
- an autoimmune disorder (e.g. lupus or rheumatoid arthritis)
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cause of high monocyte count
- a chronic inflammatory disease (e.g. inflammatory bowel disease)
- a parasitic or viral infection
- a bacterial infection in your heart
- a collagen vascular disease (e.g. lupus, vasculitis, or rheumatoid arthritis)
- certain types of leukemia
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cause of high eosoniphils count
- an allergic reaction
- a skin inflammation (e.g. eczema or dermatitis)
- a parasitic infection
- an inflammatory disorder (e.g. inflammatory bowel disease or celiac disease)
- certain cancers
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cause of low eosoniphils count
intoxication from alcohol or excessive production of cortisol (a steroid produced naturally in the body)
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cause of high basophils count
- a serious food allergy
- inflammation
- leukemia
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cause of low basophils count
- a severe allergy
- Hyperthyroidism (a condition in which the thyroid gland is overactive)
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total WBC count and total RBC count
determines the total number of that cell type per unit volume of blood
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leukocytosis
an abnormally high WBC count, may indicate bacterial or viral infection, metabolic disease, hemorrhage, or poisoning by drugs or chemicals
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leukopenia
a disease in the white cell number beloow 4000/mm3, may indicate typhoid fever, measles, infectious hepatitis or cirrhois, tuberculosis, or excessive antibiotic or X-ray therapy
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leukemia
a malignant disorder of the lymphoid tissues characterized by uncontrolled proliferation of abnormal WBCs accompanied by a reduction in the number of RBCs and platelets, is detectable not only by a total WBC count but also by a differential WBC count
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Polycythemia
an increase in the number of RBCs, may result from bone marrow cancer or from living at high altitudes where less oxygen is available.
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anemia
a decrease in the number of RBCs, may result from a decrease in RBC number or size or a decreased hemoglobin content of the RBCs
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general locations of clusters of lymph nodes and lymphatic organs and MALT
- 1) the cervical region
- 2) The axillary region
- 3) The inguinal region
- 4) The pelvic cavity
- 5) The abdominal cavity
- 6) the thoracic cavity
- tonsils (in pharyngeal region)
- thymus (in thorax; most active during youth)
- spleen (curves around left side of stomach)
- peyer's patches (in intestine)
- appendix
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