Research Module 7

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epm49
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310436
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Research Module 7
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2015-10-28 11:15:07
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GU quantitative
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Quantitative research design
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  1. What does this describe:
    What would have happened to the same people exposed to a causal factor, if they were simultaneously not exposed to the causal factor
    The term "counterfactual"?
  2. Name 3 criteria for establishing causality in a study?
    • 1. temporal: cause must precede an effect in time.
    • 2. empirical relationship btw the presumed cause and presumed effect
    • 3. 3rd variable: relationship cannot be presumed to be due to a 3rd variable
  3. What research design is considered "the gold standard" for establishment of causal relationships in variables
    RCT's
  4. What are the 3 key characteristics of an RCT?
    • 1. manipulation
    • 2. control:
    • 3. randomization
  5. In RCT's, the design feature of manipulation means that researchers manipulate the ________ by administering a __________ to some subjects and withholding it from others
    • independent variable
    • intervention/treatment
  6. The independent variable is always considered the presumed ____________ of the phenomenon
    cause
  7. The dependent variable is considered the presumed ______________
    outcome
  8. In this example: what is the IV and the DV?

    Gentle massage is an effective pain relief strategy for nursing home residents
    • IV: massage
    • DV: pain relief
  9. What is a PCI?
    Patient controlled intervention
  10. What is meant by an "attention control group"
    an added study group that hopes to control for the effect of "attention" that the participants receive from the intervention
  11. Define "random" as in rand assignment or random allocation
    Each subject has an equal chance of being assigned to any group
  12. What is the "Table of Random numbers?"
    table where any digit from 0-9 is equally likely to follow any other digit; going in any direction from any point in the table produces a random sequence
  13. What is allocation concealment?
    random assignment should involve this method which prevents those who enroll participants from knowing upcoming assignments; intended to prevent bias that could stem from knowledge of allocations before assignments actually occur
  14. What is cluster randomization?
    assigning groups or "clusters" of people to different treatment groups
  15. ________, _________and _______, and should all be done prior to random assignment?
    • screening for eligibility
    • obtaining informed consent
    • collection of baseline data
  16. What is baseline data?
    Pre-intervention data which are collected to measure key outcomes
  17. What is randomized consent AKA a "Zelen design?"
    a randomization variant where subjects are randomized first AND then informed consent is obtained, thus eliminating possibility that the consent process will generate preferences and drop outs
  18. Blinding, or masking prevents biases stemming from __________
    awareness
  19. ________ involves concealing information from participants, data collectors, care givers, intervention agents or data analysts in order to enhance __________ and minimize_______
    • Blinding or masking
    • objectivity
    • expectation bias
  20. ________bias refers to systematic differences in care provided to members of different groups of participants, apart from an intervention that is the focus of the inquiry
    Performance
  21. ________ bias concerns systematic differences between groups in how outcome variables are measured, verified, or recorded, is addressed by blinding those who collect the outcome data, or in some cases those who analyze it
    Detection or ascertainment
  22. An ______study is one in which blinding is not used.  A ________study results from masking.
    • open
    • closed
  23. When blinding is only used for one group of people (e.g. study participants) is is called___________
    single-blind
  24. _______ involves masking those who receive and those who deliver the treatment
    double-blind
  25. A _________ design involves data collection on the dependent variable only once, after randomization and completion of the intervention.
    • post-test only/after-only design
    • Basic Experimental Design
  26. A ___________ design involves testing subjects at least twice (before and after the intervention.) In this design, researchers cn measure _________.
    • Pre-test-post-test design/before-after design
    • change
  27. A _________ design includes data collection at multiple post-intervention points
    repeated measures
  28. Designs that involve collected data multiple times from two groups can be described as __________. Analyses can examine both differences ________ and changes _______ over time
    • Mixed designs
    • between groups
    • within groups
  29. An experimental design in which 2 or more independent variables are simultaneously manipulated, permitting a separate analysis of the main effects of the IVs and their interaction.
    Factorial
  30. Effects from experimentally manipulated variables
    Main effects
  31. Effects from combining treatments
    interaction effects
  32. An experimental design in which one group of subjects is exposed to more than one condition or treatment, preferably in random order.
    Cross-over design
  33. The process of systematically varying the order of presentation of stimuli or treatments to control for ordering effects, especially in a cross-over design.
    counterbalancing
  34. The influence that 1 treatment can have on subsequent treatments, notably in a cross-over design.
    carry-over effects
  35. A period of no treatment exposure to reduce the potential concern of carry-over effects
    washout period
  36. The effect on the dependent variable resulting from subjects' awareness that they are participants under study
    Hawthorne Effect
  37. Another term for Quasi-Experimental designs which involve an intervention in the absence of randomization
    Controlled trials without randomization
  38. Design includes 2 groups of participants, from whom outcome data are collected before and after implementing an intervention.
    Non-equivalent control group pretest-posttest design
  39. The term used in Quasi-experiments in lieu of control group?
    comparison group
  40. a sophisticated method of matching subjects on more than a couple variables
    propensity matching
  41. a metric that captures the conditional probability of exposure to a treatment given various pre-intervention characteristics; can be used to match comparison groups or as a statistical control
    propensity score
  42. In lieu of using a contemporaneous non-randomized comparison group, a _______ is often used
    Historical comparison group
  43. A quasi-experimental design involving collection of data over an extended period of time, with multiple data collection points both prior to and after the intervention
    Time series design
  44. An intervention study that tests the effectiveness of of an intervention with a single subject, typically using a time series design; sometimes called________
    single subject experiment or "N of 1 experiment"
  45. In quasi-experiemental designs, this is an analysis to assess whether larger doses of an intervention are associated w/ greater benefits
    Dose-response analysis
  46. A threat to internal validity in quasi-experimental designs; an alternative explanation, competing w/ the researcher's hypothesis, for interpreting the results of the study
    rival hypotheses
  47. studies in which the researcher collects data without introducing an intervention; also called observational research
    non experimental research
  48. These study designs are used in non experimental research where researchers study the effect of a potential cause that they cannot manipulate
    correlational studies
  49. a relationship or association between 2 variables, or a tendency for variation in one variable to be related to variation in the other variable
    correlation
  50. A study design that begins with the manifestation of the dependent variable (lung cancer) in the present, followed by a search for the presumed cause occurring in the past (smoking)
    retrospective study design
  51. a non-experimental design involving the comparison of a "case" and a matched control
    case control design
  52. a study design that begins with an examination of presumed causes and then goes forward in time to observe presumed effects; also called a _______ design
    • Prospective study
    • cohort design
  53. a non-experimental study that takes advantage of a naturally occurring event that is explored for its effect on people's behavior or condition, typically by comparing people exposed to the event with those who were not
    natural experiment
  54. A regression-based procedure for testing causal models, typically using correlational data
    path analysis
  55. a statistical procedure for predicting values of a dependent variable based on one or more independent variables
    regression analysis
  56. a type of non-experimental, correlational research which seeks to describe relationships among variables rather than support inferences of causality
    descriptive correlation research
  57. a study that gathers information on the occurance, frequency of occurance, or average value of the variables of interest, one variable at a time, without focusing on interrelationships among variables
    Univariant descriptive studies
  58. Two types of descriptive studies from field of epidemiology
    • 1. prevalence studies
    • 2. incidence studies
  59. __________studies are done to estimate the _________ rate of some condition at a particular point in time; rely on __________ designs in which data are obtained from the population at risk of the condition.
    • prevalence
    • prevalace
    • cross-sectional
  60. What is the formula for a Prevalence Rate?
    • # of cases with the condition/disease
    • at a given point in time (subjects in study with the condition)
    • ___________________________________
    • # in the population at risk of being a case
    • (size of the sample)
  61. ___________ studies estimate the frequency of developing new cases
    Incidence
  62. __________ designs are need to estimate incidence b/c the researcher must first establish who is at risk of becoming a new case; that is who is free of the condition at the outset
    Longitudinal
  63. an estimate of risk of "caseness" in one group as compared to another, computed by dividing the absolute risk for one group by the absolute risk for another; also called the _______
    relative risk or risk ratio
  64. Limitations of correlational research include a weakness in their ability to _____________
    support causal influences
  65. In correlational studies, researchers work with pre-existing groups that were not formed at random, but rather via _____________, which increases _________bias.
    • self-selection
    • selection
  66. _______________ may be a plausible alternative explanation for any group differences on the outcome variable in correlational studies.
    Preexisting differences among groups
  67. Correlational research is very efficient in ______________about a problem.
    collecting a large amount of data
  68. 3 broad design categories
    • 1. non experimental; observational
    • 2. quasi-experimental
    • 3. experimental

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