enoxaparin (lovenox)-LMWH(10x less thrombocytopenia) SQonly.
- Therapeutic class: Anticoagulant
- Preg. C: C
- MOA: Combines with Antithrombin III to Inactivate clotting factors IX,X,XI,XII. Inhibit conversion of prothrombin to thrombin. May be given IV infusion or SQ only. Low molecular weight heparin is SQ and always given in abdomen*safer.
- Indications: Acute thromboembolic disorders, DVT, Pulmonary embolism, Unstable angina, Evolving MI, Prophylaxis
- Contraindications: Severe HTN, Severe thrombocytopenia (low platelets in blood), serious renal or hepatic impairment.
- Adverse effects: Abnormal bleeding, Heparin induced thrombocytopenia.
- Interactions: Potentiation with other anticoagulant, inhibited anticoagulation with nicotine, digoxin, tetracyclines, antihistamines. Ginger, garlic, green tea, and ginkho.
- Precaution: dosage in units, double check dose. Read lab values before giving. Monitor aPTT (activated partial thromboplastin time)- Goal 1.5 to 2.5 times control value. Control 25-35 seconds which is normal. Over 100 seconds too high.
- Antidote: plasma-protamine sulfate given IV, 1mg for every 100 units of heparin