Card Set Information
Describe Hantavirus disease in humans.
bilateral interstitial pulmonary infiltrates and respiratory compromise
Reservoir for Hantavirus.
rodents (deer mice-Peromyscus)
What kind of virus is Hantavirus (Sin Nombre virus)?
Describe the prodromal (initial) stage of Hantevirus infection in humans. (5)
fever, chills, myalgia, headache, GI symptoms
Describe the pulmonary signs of Hantavirus in humans. (4)
tachypnea, tachycardia, hypotension, crackles or rales on lung auscultation [may eventually need assisted ventilation]
Describe transmission of Hantavirus b/w mice. (5)
chronically-infected rodent--> horizontal transmission by aggressive behavior b/w mice, aerosols, contact with mucous membranes, skin breaches, urine
What are routes of human infection with Hantavirus. (3)
inhalation of aerosolized saliva and urine
, dried excreta contact with broken skin/mucous membranes, rodent bites
Risk factors for contraction of Hantavirus. (3)
rodent in household, cleaning (other activities that aerosolize dust), certain occupations (grain farmers, livestock herdsmen, etc)
___________ infection is not considered a risk factor for Hantavirus.
Describe prevention of Hantavirus infection. (2)
control mice inside and outside, use PPE (gloves, masks) when cleaning
The etiologic agent of monkeypox is a ____________ that was first discovered in ___________.
orthopoxvirus; African monkeys
Is monkeypox easily transmitted from human to human?
What is the reservoir for monkeypox in endemic areas?
Describe infections with monkeypox virus in humans. (5)
fatigue, fever, muscle pain, progressing to vesicles and pustules that scab in about 10 days, lymphadenopathy
Clinical signs of monkeypox virus in rabbits and rodents. (9)
conjunctivitis, nasal d/c, fever, cough, lymphadenopathy, lethargy, anorexia, progressing to nodular rash and pneumonia
Clinical signs of monkeypox in monkeys. (2)
pus-filled papules on hands/trunk/tail, ulcers in mouth
Monkeypox was transmitted to an american family,veterinarian, and a rabbit at the vets office by a(n) ___________.
How the the FDA-CDC act to prevent/control monkeypox in the US?
banning the importation and sale of African rodents and prairie dogs
How long should you quarantine animals that came in contact with monkeypox? How long should people exposed to monkeypox be alert for signs and symptoms?
30 days for both
What species are persistently infected with lymphocytic choriomeningitis virus?
mice and hamsters
Lymphocytic choriomeningitis virus causes what 3 syndromes?
aseptic meningitis, encephalitis, or meningoencephalitis
What rodent-transmitte disease is VERY dangerous during pregnancy, and what does it cause in the fetus?
lymphocytic choriomeningitis virus; congenital hydrocephalus, chorioretinitis, and mental retardation
What is the primary host and natural host of lymphocytic choriomeningitis virus?
house mice- Mus musculus
Where is lymphocytic choriomeningitis virus found in mice?
saliva, urine, feces
What disease does LCMV cause in rodents?
How do humans contract LCMV? (5)
fresh urine, fecal droppings, saliva, contaminated nesting materials; contact of these substances with broken skin or conjunctiva; ALSO vertical transmission from mother to fetus
Describe prevention of LCMV. (4)
rodent control, ventilate rooms that may be contaminated before cleaning, clean with bleach, wear PPE when cleaning