Urinary2- Renal Patho 2
Card Set Information
Urinary2- Renal Patho 2
Dissolution of the glycocalyx leads to __________.
Viability of the glomerular endothelial cells requires _________, which comes from the _________.
___________ is the hallmark of glomerular disease.
What are the 4 components of nephrotic syndrome that may result from glomerular disease?
proteinuria, hypoalbuminemia, edema/ascites, hypercholesterolemia/hyperlipidemia
What is NOT a criterion for diagnosis of nephrotic syndrome?
Gross lesions associated with acute glomerular disease. (3)
swollen, smooth capsular surface, glomeruli may be red
Gross lesions associated with chronic glomerular disease. (4)
pale, firm, irregular capsular surface, granular cortex on cut surface
What are the 2 large categories of glomerular disease in animals?
imune complex mediated glomerular nephritis (ICGN), non-ICGN
What 3 diseases are immune complex-mediated GN?
membranoproliferative GN, membranous GN, mesangioproliferative GN
What 4 disorders are non-ICGN?
amyloidosis, focal segmental glomerulosclerosis, podocytopathy, GBM-opathy
Disorder with immune complexes acting as aggregates of Ag and Ab in glomeruli.
immune complex-mediated glomerulonephritis
What are some examples of glomerular lesions? (5)
hypercellularity (mesangial or endocapillary), mesangial expansion, immune deposits, deposition of fibrils, GBM remodeling
With membranous GN, immune complexes are on the _________ of the glomerular BM.
With membranous GN, complement is activated ___________ the capillary lumen, resulting in...
away from (b/c IC are in abluminal surface of BM); inflammatory cells are not attracted to tuft and podocytes are damaged.
Causes of secondary membranous GN. (3)
infections, neoplasia, drugs
With membranoproliferative GN, there is __________ hypercellularity due to __________.
endocapillary; subendothelial deposits of IC
3 lesions associated with membranoproliferative GN.
endocapillary hypercellularity, mesangial hypercellularity, glomerular BM remodeling
Amyloidosis is caused by... (2)
genetic predisposition or chronic inflammation
Describe the non-genetic pathogenesis of amyloidosis.
chronic inflammation--> increase SAA--> circulates in blood--> trapped in kidney--> fibrils deposited in glomeruli/interstitium
Focal glomerulosclerosis occurs because of ___________
Podocyte injury leads to... (3)
sclerosis, fibrosis, syenchiae (adhesions b/w GBM and Bowman's capsule BM)
Primary focal segmental glomerulosclerosis is assumed to be due to...
abnormal podocyte genes/proteins.
Secondary focal segmental glomerulosclerosis is due to... (3)
podocyte injury due to systemic hypertension, obesity, or decreased nephron mass (which causes increase SNGFR).
What is an example of a glomerular BM-opathy?
Alport's syndrome- mutation in type IV collagen that leads to weaker glomerular BM
Multifocal embolic nephritis in a foal is caused by septicemia with __________.