patho exam 4 part 1 (Ebola)
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Ebola multiplies rapidly and powerfully that the body's infected cells become .. ?
- crystal-like blocks of packed virus particles (that are ready for hatch from cell [aka bricks].) Bricks appear near center of cell and then migrate towards surface. As crystal reaches cell wall, it integrates into hundreds of individual virus particles, and broodlings push thru cell wall (like hair) and float in bloodstream; continues until droplet of blood contain million individual particles.
- -even in death virus isnt finished, corpse's tissues, skin, organs begin to liquefy.
How is Ebola transmitted?
via contact w/skin and blood.
What does Ebola resemble that other viruses do not ?
resembles a thread instead of a peppercorn
How many proteins does Ebola contain?
7; consume body while virus makes copies of itself
Ebola is a tubular virion, in the center is the viral nucleocapsid that consists of 4 different proteins.. what are they ?
helical ssRNA genome wrapped about NP, VP35, VP30, and L proteins.
What happens when Ebola makes 2 glycoproteins?
protein synthesis of infected cells and host immune defenses=overwhelmed
When GP1 binds virus to endothelial cells lining interior surface of blood vessel it reduces what?
- specific integrins (resposible for cell adhesion to inter-cellular structure)
- -->blood vessel walls become damaged and platelets are unable to coagulate, patients succumb to hypovolemic shock.
A secretory form of GP2 interferes with neutrophils signaling and allows the virus to do what?
- evade immune sys by inhibiting early steps of neutrophil activation.
- viral particles + cell damage resulting 4rm budding = release of cytokines; which are associated with fever & inflammation
=infected body corroding(eating) away from inside
What are the 3 immune responses of Ebola?
1. Filoviruses infect monocyte, marcophages and dendritic cell.
2. Infected monocytes release large amounts of destructive inflammatory cytokines
3. Monocytes and dendritic cells normally play vital roles in stimulating the adaptive immune system (Antibodies) as well as activating CD4+T helper cells.
-Dentritic cells normally initiate T and B lymphocyte (antibody production) to novel antigens.
What was the strategy that African tribes had to stop Ebola?
time & quarantine
(put diseased in a straw hut, and burned it down)
What are the factors affecting transmission of Ebola?
- reusing syringes; no isolation procedures
- tradition; dying & dead were cleaned by washing undertaken by family members
-80% mortality rate
What is the 'potential game-changer' for Ebola?
-combined fragment of Ebola virus with another safer virus to train immune sys to beat Ebola.
Main symptoms of Ebola are?
hemorrhage and fever
What would you like to do?
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