Cattle2- BLV BLADS
Card Set Information
Cattle2- BLV BLADS
What are the 2 types of lymphosarcoma and their subtypes?
sporadic- juvenile, thymic, cutaneous; enzootic- BLV-associated
In what animals does juvenile lymphosarcoma occur?
calves <6 months old
Clinical signs of juvenile lymphosarcoma. (3)
sudden, symmetrical enlargement of peripheral ln; +/- bloat; +/- heart failure [depending on what internal ln are involved]
In what animals does thymic lymphosarcoma occur?
6 months old- 2 years old
clinical signs of thymic lymphosarcoma. (2)
enlarged thymus--> jugular distension, respiratory distress
In what animals does cutaneous lymphosarcoma occur?
1-3 years old
Clinical signs associated with cutaneous lymphosarcoma. (3)
plaque-like lesions on body, may undergo spontaneous regression and recurs as enzootic form
Describe the potential regression and recurrence of cutaneous lymphosarcoma.
cutaneous form w/ lesions, animal is serologically BLV (-); spontaneous regression; recurrence of disease, animal is serologically now BLV (+)
In what animals do you usually see enzootic BLV?
4-8 years old
What is the etiologic agent for enzootic lymphosarcoma?
bovine leukemia virus- oncogenic retrovirus
How is BLV transmitted b/w animals? (4)
horizontal transmission-whole blood, colostrum via maternal lymphocytes, iatrogeneically, +/- semen
BLV infects _________[cells] and there is cell-associated _________.
B lymphocytes; viremia
What are the major predilection sites for enzootic lymphosarcoma in adult animals? (4)
abomasum, right heart, uterus, spinal cord
With abomasal involvement, what are clinical signs of enzootic BLV? (4)
vagal indigestion (impaired flow), ulceration, melena, peritonitis
If you see an early-to-mid gestation pregnant cow with an abomasal ulcer, what is your top differential and why?
enzootic BLV with abomasal involvement because usually during pregnancy, high progesterone is protective to the abomasum against ulceration
With cardiac involvement, what are signs of enzootic BLV? (4)
muffled heart sounds, jugular distention, brisket/submandibular edema, ascites
With spinal cord involvement, what are signs of enzootic BLV? (2)
posterior ataxia, paralysis
With uterine involvement, what are signs of enzootic BLV? (2)
abortion, failure to conceive
How do you diagnose enzootic BLV? (4)
FNA of enlarged lymph nodes, AGID test, necropsy, persistent lymphocytosis (DOES NOT AUTOMATICALLY MEAN THE ANIMAL WILL DEVELOP LYMPHOSARCOMA)
Describe prevention and control methods for enzootic BLV. (4)
test and cull, new needle used for every animal, new rectal sleeve for every animal (yeah right!), disinfect all equipment b/w animals
In what animals does BLADS occur?
What gene is defective in BLADS animals?
What is the defect associated with BLADS?
leukocytes lack ability to adhere to vessel walls--> can't marginate to sites of infection--> can't fight infection
Clinical signs associated with BLADS. (4)
recurrent infections, gingivitis, granulomatous stomatitis, inappropriately elevated leukocyte counts
How do you diagnose BLADS? (3)
blood test, DNA test, looks for escalating WBC counts (easily exceeding 100k cells/μL)