anti-arrhythmia drug that blocks Na channels and M2 receptors but doesnt block alpha 1 receptors
anti-arrhythmia drug. Na+ channel block, no M2 or Alpha-1 block Prefer iv route to avoid metabolism or slow metabolism. Can lead to lupus syndrome, long QT syndrome, and torsades des pointes
anti-arrhythmia drug that can lead to lupus syndrome if not metabolized and lead to long QT syndrome and torsades des pointes if metabolized to NAPA
orally available versions of lidocaine
Class IB anti-arrhythmia drug. Given iv, short-acting and safe. Used for ventricular extrasystoles Activates AV node to increase conduct. Can suppress digoxin V. arrhythmias w/o aggravating dig.-related AV node depression
Class IC anti-arrhythmias. Potent sodium channel blockers CAST trial revealed danger, therefore used only as last resort or short-term
Flecainide, Encainide, Moricizine
Class III anti-arrhythmia drug. Long t1/2, difficult dosing. Many dangerous and unusual side effects: Cardiac depression, pulm. fibrosis, liver damage, optic nerve, cornea halos, and blue skin
Arrhythmias of sodium-conducting pathways of atria or ventricles respond to...
class I and III drugs
Arrhythmias of calcium-conducting sites, SA node, AV node respond to...
class II and IV drugs
Atrial flutter, a fib treatments
Digoxin- AV depression, Protect the ventricle, Also verapamil, beta blockers. Class IA to suppress the sodium driven ectopic focus or foci.
SVT caused by Atrial, AV node reentry circuit can be treated with...
Verapamil, beta blockers, digoxin, and adenosine (all AV depressants)
SVT caused by atrial wall re-entry can be treated with
Inhibit initiation of action w/ Class IA - Quinidine, etc.
Increase refractoriness w/ Class III – Amiodarone
Treatment for Premature V contraction, extra systoles, EADs, DADs
Lidocaine, other class I drugs, and beta blocker in SNS
Ventricular tachycardia Caused by repeated ectopic depolarizations in conducting tissue or by a conducting path reentry circuit. Sodium driven. can be treated w/
Lidocaine, class IA, or Class III drugs
V fib can be treated w/
Class IA, IB, and class III
treatment for Digitalis - induced arrhythmias. Extrasystoles or Vtach w/ added danger of AV nodal depression.
Class IB, phenytoin, Procainamide. All has no AV depression effect
block ADP – prevents platelet formation
Bronchodilation, vasodilation, cardiac stimulation due to phosphodiesterase inhibition (cAMP)
treatments for pulmonary congestion due to acute heart failure