What is the recommendation for gonadectomy of male dogs?
What are the benefits of spaying female dogs? (2)
decreased mammary neoplasia and pyometra
What are the detriments of spaying female dogs? (4)
obesity, increased osteosarc/TCC/hemangiosarc/CCL rupture, urinary incontinence, early spay and juvenile vulvar conformation (chronic/recurrent UTIs) [controversial]
What is the recommendation for gonadectomy of female dogs?
case-by-case (usually after 4 months of age and before first cycle)
Pharmacological methods to suppress reproduction. (4)
progestins- Megestrol acetate (Ovaban), Medroxyprogesterone Acetate (not approved- long acting)
GnRH agonists- Deslorelin
How do progestins suppress reproduction?
suppress gonadotropin release (no LH surge), thus preventing ovulation
What are the side effects of Megestrol Acetate? (3)
weight gain, lethargy, mammary development
After you stop Megestrol Acetate, return to estrus in __________.
Drug that is safe and effective for long-term estrus suppression, but treatment must start 30 days prior to estrus.
How do GnRH agonists prevent estrus?
suppress pituitary function
Giving Deslorelin during estrus causes _____________; giving it during diestrus causes _____________; giving it during anestrus causes ____________.
ovulation; best results preventing estrus; estrus in ~7 days
What are 3 methods of immuno-contraception?
anti-GnRH, anti-sperm proteins, and anti-ZP (zona pellucida) vaccines
What method of contraception can be given to males?
zinc gluconate injection (Neutersol) into testicles, inducing sclerosis and sterility
How should you NOT manage mismating scenarios? What is the downside to this?
estrogens (impair oocyte transport in oviduct if given after ovulation and before day 2)- Estradiol Cypionate; BM suppression (aplastic anemia-death) is possible, pyometra, cystic endometrial hyperplasia [advised against doing this]
How SHOULD you manage mismating scenarios? (4)
PGF injection after day 7 of diestrus (post-ovulation) continued until complete abortion
Dopamine agonists (suppress prolactin) after 25-30 days of gestation
Dexamethasone after day 35 (but much longer treatment)
Progesterone antagonists Mifepristone/Aglepristone [not used in U.S.]
Why should you hospitalize a dog if you are aborting a pregnancy with lutalyse?
PGF injections 3 times a day for a few days- hyperpnea/salivation/emesis/diarrhea after each injection