Pharm Across Lifespan

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  1. Pediatric excretion-kidneys
    Before 9 months of age-renal blood flow is decreased, decreasing ability to excrete drugs.
  2. Pediatric BBB?
    Not fully developed will allow drugs to pass through.
  3. Pediatrics Plasma proteins?
    Lower plasma proteins-higher free drug levels that are protein bound.
  4. Pediatric Body fat?
    Lower percentage-lipid soluble drugs stay in blood longer.
  5. Pediatric Liver function?
    Immature liver-decreased ability to metabolize drugs.CYP450 reaches adult level at age 2-3 years.
  6. Pediatric-body water?
    Increased percentage-dilutes water soluble drugs such as furosemide.
  7. Pediatric-Skeletal muscle?
    Less blood flow to skeletal muscle considered during IM injections
  8. Pediatric-absorption?
    Increased stomach PH-reaches normal levels at 2-3years. drugs stay in GI longer
  9. Geriatric-BBB?
    Increased permeability allowing certain medications to pass through such as antiepileptic meds.
  10. Geriatric-Excretion?
    Excretion slowed due to liver/kidney function with age-half life of drugs  increase-leading to toxic levels sooner.
  11. Geriatric-Plasma protein?
    Reduced by 13% increase in protein bound drugs being unbound leading to toxicity.
  12. Geriatric-GI?
    Gastric PH increases, slowed GI motility. Drugs stay in GI longer-leads to increase in nausea.
  13. Geriatric pharmacokinetics-Distribution body weight?
    Fat storage increases-allowing lipid soluble drugs to stick around longer
  14. Geriatric-pharmacokinetics- water soluble drugs?
    Total body water decreases, increase level of water soluble drugs.
  15. Blood flow to kidneys of pregnant patient do what?
    Increase by 50% which can lead to adjustments in drug dosages due to faster excretion.
  16. Concern for drug administration in patients that are breast feeding?
    Fat soluble drugs distributed to lipid rich breast milk passing to feeding infant.
  17. Pregnant patient will have increased blood volume causing what to drug distribution?
    dilution of drugs and decreases plasma concentrations.
  18. what does increased progesterone levels cause? Related to pregnancy
    A delay in gastric emptying-allowing longer absorption of oral drugs
  19. What drugs are less likely to cross placental membrane?
    drugs that are water soluable, ionized, or bound to plasma proteins are less likely to cross the placenta
Card Set:
Pharm Across Lifespan
2016-06-27 04:54:15
1st Year Nursing Pharm
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