Autonomic Nervous System

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  1. Phenylalanine is converted to what to start the synthesis process of catecholamines?
    Tyrosine 

    by phenylalanine transferase
  2. Tyrosine ---> DOPA
    Tyrosine Hydroxylase
  3. DOPA ---> Dopamine
    DOPA Decarboxylase
  4. Dopamine ---> Norepinepherine
    Dopamine beta-hydroxylase
  5. Norepinephrine-- > epinephrine
    Phenylethanolamine N-methyltransferase
  6. alpha 1 receptor agonists
    • norepinephrine
    • epinephrine
    • dopamine
    • isoproterenol
  7. alpha 1 receptor antagonists
    • phenoxybenxamine
    • phentolamine
    • ergot alkaloids
    • prazosin
    • tolazoline
    • labetalol
  8. Alpha 1 receptor locations
    • Smooth muscle (vascular, iris, radial, ureter, pilomotor, uterus, trigone, gastrointestinal, and bladder sphincters)
    • Brain
    • Gastrointestinal smooth muscle
    • Heart
    • Salivary glands
    • Adipose tissue
    • Sweat glands
    • Proximal tubule of kidney
  9. Alpha 1 receptor actions
    Smooth muscle  Contraction/Vasoconstriction

    Brain Neurotransmission

    GI Smooth muscle relaxation

    Heart  Glycogenolysis

    Salivary glands  increased force, glycolysis

    Adipose tissue  K/H2O secretion

    Sweat glands  glycogenesis

    Proximal tubule of kidney  Secretion, gluconeogenesis, sodium reabsorption
  10. Alpha 2 receptor agonists
    • clonidine
    • Norepinephrine
    • Epinephrine
    • Norepinephrine
    • Phenylephrine
  11. Alpha 2 antagonists
    • yohimbine
    • piperoxan
    • phentolamine
    • phenoxybenzamine
    • tolazoline
    • Labetalol
  12. Alpha 2 receptor locations
    Adrenergic nerve endings

    presynaptic in CNS

    Platelets

    Adipose tissue

    Pancreas (endocrine)

    Vascular smooth muscle

    Kidney

    Brain
  13. Alpha 2 receptor actions
    Adrenergic nerve endings--Inhibition of NE release

    presynaptic in CNS-- Inhibition of NE release 


    Platelets--  Aggregation, granule release


    Adipose tissue-- inhibition lypolysis


    Pancreas (endocrine)-- inhibit insulin release

    Vascular smooth muscle-- Contraction

    Kidney-- inhibition renin release

    Brain-- Neurotransmission
  14. Beta 1 receptor agonists
    • isoproternol
    • Epinephrine
    • Norepinephrine
    • Dopamine
  15. Beta 1 receptor antagonists
    • acebutolol
    • practolol
    • propranolol
    • alprenolol
    • metoprolol
    • esmolol
  16. Beta 1 receptor locations
    Heart

    Adipose tissue
  17. Beta 1 receptor action
    Heart-- Increased rate, contractility, conduction velocity,  coronary vasodilation

    Adipose tissue-- lipolysis
  18. Beta 2 agonists
    • isoproterenol
    • epinephrine
    • norepinephrine
    • dopamine
  19. Beta 2 antagonists
    • propranolol
    • butoxamine
    • alprenolol
    • esmolol
    • nadolol
    • timolol
    • labetalol
  20. Beta 2 receptor locations
    Liver

    Skeletal muscle

    Smooth muscle (bronchi, uterus, vascular, GI, detrusor, spleen capsule) 

    Pancreas (endocrine) 

    Salivary glands
  21. Beta 2 receptor actions
    Liver-- glycogenolysis, gluconeogenesis

    Skeletal muscle-- Glycogenolysis, lactate release

    Smooth muscle (bronchi, uterus, vascular, GI, detrusor, spleen capsule)   Relaxation

    Pancreas-- insulin secretion

    Salivary glands--  amylase secretion
  22. Dopaminergic 1 receptor agonists
    • Fenoldopam
    • Dopamine
    • Epinephrine
    • Metoclopramide
  23. Dopaminergic 1 receptor antagonists
    • Haloperidol
    • Droperiol
    • Phenothiazines
  24. Dopaminergic 1 receptor locations
    Vascular smooth muscle

    Renal and mesentary vessels
  25. Dopaminergic 1 receptor actions
    Vascular smooth muscle-- Vasodilation

    Renal and mesentary-- vasodilation
  26. Dopaminergic 2 receptor agonists
    Dopamine

    Bromocriptine
  27. Dopaminergic 2 receptor antagonist
    Domperidone
  28. Dopaminergic 2 receptor location
    Presynaptic-adrenergic nerve endings
  29. Dopaminergic 2 receptor actions
    inhibits norepinephrine release from presynaptic adrenergic nerve endings

Card Set Information

Author:
nikistivers
ID:
314156
Filename:
Autonomic Nervous System
Updated:
2016-01-17 22:11:49
Tags:
ANS PNS SNS catecholamines
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Description:
ANS
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