Biochem 4000 - Lecture 3 PII

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  1. Amphipathic β-sheet
    • One side polar, other side np
    • Always paralell
  2. Parallel β-sheet sequence structure
    • -X-np-X-np-X-np-...
    • High strand propensity sequence
  3. General structure of mixed β-sheets
    • Antiparallel sheets on outside and parallel inside
    • (Outside H-bonds stabillize inside ones)
  4. Types of bonding (van der vaals radii)
    • Ionic - At van der vaals distance
    • Covalent - Less than van der vaals distance
    • Hydrogen - Somewhere in between
  5. Why are antiparallel sheets more stable
    • Straight H-bonds are stronger
    • Straight H-bonds are closer together too
  6. β-sheet rotation
    • Left handed
    • First strand back will be ~25° from strand closest and so on...
  7. β-bulge
    • Single residue strand disruption of β-sheet hydrogen bonding
    •  - 95% are in parallel
  8. Difference between β-bulge and β-corner
    Bulge is a gentle curve and a corner is a tight one
  9. Types of β-bulge
    • Classic (90% of anti, 60% of parallel)
    • Wide
    • Bent
    • Special
  10. β-bulge structure
    • Identical to regular β-sheet, except one residue slipped in
    • Bidentate H-bond
    • Chains cross over
    • Image Upload
  11. β-corner
    Two residue disruption of a sheet
  12. Type I' turn
    • i to i+3 H-bonding
    • 90° bend

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Author:
Ant
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315496
Filename:
Biochem 4000 - Lecture 3 PII
Updated:
2016-02-11 21:02:34
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Biochemistry 4000
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Biochem 4000
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