GU Antiarrhythmics

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  1. Decreases conduction velocity
    • Class Ia
    • Procainamide, Quinidine, Disopyramide
  2. Shortens depolarization and QT interval
    • Class Ib
    • Lidocaine, Mexilitine
  3. Prolongs repolarization
    Class Ia & Ic
  4. Prolongs QT; risk for TdP
    Class Ia
  5. Most potent Na+ channel blockade; depressive & pro-arrhythmic effects
    • Class Ic
    • Flecainide, Propafenone, Moricizine, Encainide
  6. Used for ventricular arrhythmias, NOT effective for SVT
    • Class Ib
    • Lidocaine, Mexilitine
  7. Anticholinergic effects
    Class Ia
  8. AEs primarily neurological
    • Class Ib
    • Lidocaine, Mexilitine
  9. AKA beta-blockers.
    Class II
  10. Has a negative inotrope effect.
    Class II
  11. Class II slow ____ firing and conduction through the _______.
    • SA node
    • AV node
  12. Which drugs in class II also have BB action?
    • amidoarone
    • Sotalol
    • Dronaderone
  13. Which class III drugs can cause Torsades de Pointe?
    • Ibutilide
    • Dofetilide
    • (can be an AE of Sotalol)
  14. Similar to amiodarone but less AEs
    Dronaderone
  15. ______ has several CYP450 interactions including with Warfarin.
    Amiodarone (increases INR)
  16. How does amiodarone work?
    • Na, K, Ca, α-, β-blocking,
    • decreases AV conduction/SN function
  17. How do class IV work?
    • Affect depolarization via blockade of Ca++
    • causing slowed SA firing & 
    • slowed conduction through AV node
  18. Which CCB's are primarily used? Names?
    • NonDHP
    • Verapamil & Diltiazem
  19. _____ cannot be used to treat ventricular arrhythmias.
    Class IV
  20. Major AEs of class IV.
    • bradycardia,
    • excessive AV block,
    • heart failure, hypotension;
    • constipation (verapamil)

Card Set Information

Author:
MeganM
ID:
315504
Filename:
GU Antiarrhythmics
Updated:
2016-02-07 21:26:21
Tags:
GU Pharm
Folders:
Gu,Pharm,Antiarrhythmics
Description:
antiarrhythmics
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