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What's the key idea?
See spike when there's two stimuli next to each other
What's the key reason for there not being a summation/broad window of opportunity when two EPSPs come together?
There's also IPSPs
- Use a drug that blocks GABAa receptors that broadens window
- Makes sense b/c now it's consistent w/ the duration of EPSP
- Variability of spiking
- Spikes at some delay
What does GABA antagonist do to jitter?
- Expands jitter time
- Jitter happens at more variable time
Without inhibition, what happens?
Window is broader and jitter is higher
Feed-forward inhibition is responsible for what?
- Whole cell recording- cell-attach
- Bicu abolishes GABA and gets rid of inhibitory curve
- There's a delay btwn onset of excitation and inhibition (about 2 ms, very fast)
What's the reason for delay in onset of excitation and inhibition?
What's disynaptic inhibition?
- When you block inhibition, inhibition is blocked (duh)
- BUT when you block excitatory syanpse with NBQX, both excitation and inhibition goes away b/c excitatory neuron usually activates inhibitory synapse
What does it mean that a single stimuli to the excitatory neuron spikes the inhibitory neuron?
- Strong synapse
- Spike sufficient enough to spike inhibitory neuron
What's the basic message; what's the difference btwn inhibition on cell body and somewhere on dendrites?
- Fast inhibition b/c closer to axon hillock
- Slower thru dendrites