ABx B

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  1. Mechanisms of ABx Resistance
    • ● Enzymatic destruction of drug (β-lactamases)
    • ● Impaired penetration of antibiotic to target PBPs (transpeptidase)
    • ● Modification of target PBPs (binding site)
    • ● Rapid ejection of the drug (efflux)
  2. PCN + B-lactamase Inhibitor
    No antibacterial activity by themselves because they only have half of the beta-lactam part, used in combination to act as a decoy and consume the penicillinase/beta-lactamase and keep the antibiotic or penicillin protected
  3. Carbapenems BS Activity
    • ● Advantages at three different sites allows broader spectrum and increased efficacy
    • → Improved penetration of porins
    • → Enhanced binding to PBP (transpeptidase)
    • → Increased resistance to b-lactamases
  4. Imipenem (Carbapenem) with Cilastatin (Primaxin)
    • ● Inhibit renal dehydropeptidase
    • ● Imipenem is inactivated by dehydropeptidase in renal tubules
  5. Bacitracin Advantage
    No cross resistance between Bacitracin and other antimicrobial agents
  6. Sulfonamide / Trimethoprim Combination
    • ● Combination is bactericidal
    • ● Trimethoprim + sulfamethoxazole
    • ● Sulfadiazine + pyrimethamine 
    • ● Sulfadoxine + Pyrimethamine (Fansidar)
  7. Sulfonamides Ineffective Against
    • ● Rickettsiae
    • ● Anaerobes
    • ● Pseudomonas
  8. Aminoglycosides + B-lactam
    • ● Extend coverage to gram+ pathogens
    • ● Take advantage of the synergism between these two classes of drugs
    • ● Enterococcal endocarditis
    • ● Shorten duration of therapy for
    • → Viridans streptococcal infections
    • → Staphylococcal endocarditis
  9. Tetracycline Absorption
    • ● Food (except doxycycline and minocycline)
    • ● Divalent cations (Ca2+, Mg2+, Fe2+) or Al3+
    • ● Dairy products and antacids, which contain multivalent cations
    • ● Alkaline pH
  10. Methenamine CI w/Sulfonamides
    Sulfonamides should not be given at the same time because they may form an insoluble compound with the formaldehyde released by methenamine (exacerbate crystalluria)

Card Set Information

Author:
ebmalonzo
ID:
316186
Filename:
ABx B
Updated:
2016-02-20 19:19:04
Tags:
ABx
Folders:
ID 1
Description:
ID 1 (Final): ABx (B)
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