Antiarrythmics

The flashcards below were created by user ebmalonzo on FreezingBlue Flashcards.

  1. Which of the following statements is true with regards to the general principle of antiarrhythmic therapy?

    A) Antiarrhythmics may precipitate life-threatening arrhythmia
    B) Individual antiarrhythmic drug always specifically affects one subtype of channel protein
    C) A single antiarrhythmic drug can suppress all proarrhythmic activities
    D) Antiarrhythmics do not affect electrical impulse conduction
    A) Antiarrhythmics may precipitate life-threatening arrhythmia
    (this multiple choice question has been scrambled)
  2. Which of the following drugs has a wide spectrum of ion channel blocking effects (ie, affecting IKr, IKs, INa)?

    A) Lidocaine
    B) Amiodarone
    C) Ibutilide
    D) Procainamide
    B) Amiodarone
    (this multiple choice question has been scrambled)
  3. Which of the following drugs is a class 1B antiarrhythmic agent?

    A) Adenosine
    B) Propranolol
    C) Lidocaine
    D) Dronedarone
    C) Lidocaine
    (this multiple choice question has been scrambled)
  4. Which of the following therapies may prolong QT interval and cause life-threatening ventricular arrhythmia such as torsade de pointes?

    A) Amiodarone
    B) Verapamil
    C) Sotalol
    D) Propranolol
    C) Sotalol
    (this multiple choice question has been scrambled)
  5. Some drugs that are effective to treat supraventricular tachycardia (SVT) may worsen ventricular tachycardia (VT). Which of the following drugs should be used with caution in the treatment of ventricular tachycardia (VT)?

    A) Dofetilide
    B) Amiodarone
    C) Lidocaine
    D) Flecainide
    D) Flecainide
    (this multiple choice question has been scrambled)
  6. Some drugs that are effective to treat supraventricular tachycardia (SVT) may worsen ventricular tachycardia (VT). Which of the following drugs should be used with caution in the treatment of ventricular tachycardia (VT)?

    A) Propranolol
    B) Dronedarone
    C) Verapamil
    D) Procainamide
    C) Verapamil
    (this multiple choice question has been scrambled)
  7. Lidocaine produces:

    A) Use-dependent blockade in healthy heart tissue
    B) Reverse use-dependent blockade in diseased heart tissue with rapid rate
    C) Use-dependent blockade in diseased or hyperpolarized heart tissue
    D) Use-dependent blockade in diseased or depolarized heart tissue
    D) Use-dependent blockade in diseased or depolarized heart tissue
    (this multiple choice question has been scrambled)
  8. All of the followings are concerns of amiodarone therapy Except:

    A) Optic neuritis that may progress to blindness
    B) Precipitation of Torsade de Pointee
    C) Pulmonary toxicity (i.e. fatal pulmonary fibrosis)
    D) Disturbance of thyroid hormone function
    B) Precipitation of Torsade de Pointee
    (this multiple choice question has been scrambled)
  9. Both lidocaine and amiodarone:

    A) Increase QT interval by activation of L-type Ca current
    B) Prolong action potential duration by reduction of Ikr and IKs (K currents)
    C) Block Na channels (reduce INa)
    D) Are effective for ventricular tachycardia but not for atrial fibrillation
    C) Block Na channels (reduce INa)
    (this multiple choice question has been scrambled)
  10. Adenosine activates A1 receptors and causes:

    A) Na influx and depolarization of AV nodal cells
    B) K efflux and hyperpolarization of AV nodal cells
    C) Na influx and hyperpolarization of AV nodal cells
    D) K efflux and depolarization of AV nodal cells
    B) K efflux and hyperpolarization of AV nodal cells
    (this multiple choice question has been scrambled)
  11. Which of the following antiarrhythmic drugs is paired correctly with its mechanism of action?

    A) Amiodarone / reducing K currents and increasing refractory period
    B) Adenosine / activate A1 adenosine receptors and Increasing sympathetic stimulation to the heart
    C) Lidocaine / blocking L-type Ca channel and reducing AV conductivity
    D) Adenosine / antagonizing beta receptors and reducing sympathetic stimulation to the heart
    A) Amiodarone / reducing K currents and increasing refractory period
    (this multiple choice question has been scrambled)
  12. Which of the following drugs may reduce the AV conduction?

    A) ARBs
    B) Adenosine
    C) ACE inhibitors
    D) Diuretics
    B) Adenosine
    (this multiple choice question has been scrambled)
  13. Which of the following does not reduce the AV conduction?

    A) Beta-blockers
    B) ACE inhibitors
    C) CCBs
    D) Adenosine
    B) ACE inhibitors
    (this multiple choice question has been scrambled)
  14. L-type Ca channel activity determines the amplitude of slow action potentials. The amplitude of action potentials affects the impulse conduction. Which of following ECG parameters will be increased after a patient taking verapamil or diltiazem?

    A) S-T segment
    B) QRS duration
    C) Q-T interval
    D) P-R interval
    D) P-R interval
    (this multiple choice question has been scrambled)
  15. Verapamil or diltiazem prolongs P-R interval due to:

    A) Prolonging action potential duration of His-bundle
    B) Depressing the action potential amplitude of sinoatrial node and slowing impulse conduction
    C) Prolonging action potential duration of atria
    D) Depressing the action potential amplitude of atrioventricular node and slowing impulse conduction
    D) Depressing the action potential amplitude of atrioventricular node and slowing impulse conduction
    (this multiple choice question has been scrambled)
  16. Verapamil shortens Q-T interval because it:

    A) Shortens the plateau phase of ventricular action potentials
    B) Slows the phase 3 repolarization of ventricular action potential
    C) Increases action potential duration of ventricular cells
    D) Prolongs the plateau phase of ventricular action potentials
    A) Shortens the plateau phase of ventricular action potentials
    (this multiple choice question has been scrambled)
  17. Beta blocker metoprolol shortens Q-T interval because it:

    A) Prolongs the plateau phase of ventricular action potentials
    B) Increases action potential duration of ventricular cells
    C) Accelerates the phase 3 repolarization of ventricular action potentials
    D) Reduces action potential duration of ventricular cells
    D) Reduces action potential duration of ventricular cells
    (this multiple choice question has been scrambled)
  18. Procainamide prolongs Q-T interval because it:

    A) Has atropine-like action to reduce vagal tone
    B) Produces a metabolite N-acetylprocainamide (NAPA)
    C) Ca2+ current
    D) Inhibits Na+ current
    B) Produces a metabolite N-acetylprocainamide (NAPA)
    (this multiple choice question has been scrambled)
  19. Which of the following drugs has an extensive first pass metabolism?

    A) Disopyramide
    B) Amiodarone
    C) Lidocaine
    D) Mexiletine
    C) Lidocaine
    (this multiple choice question has been scrambled)
  20. Which of the following class of drugs prolongs Q-T interval that may lead to Torsade De Pointes?

    A) Class I-A
    B) Class II
    C) Class IV
    D) Class I-B
    A) Class I-A
    (this multiple choice question has been scrambled)
  21. Which of the following beta blockers prolongs Q-T interval that may lead to Torsade De Pointes?

    A) Propranolol
    B) Esmolol
    C) Sotalol
    D) atenolol
    C) Sotalol
    (this multiple choice question has been scrambled)
  22. Which of the following beta blockers has class III antiarrhythmic drug action?

    A) Sotalol
    B) Esmolol
    C) atenolol
    D) Metoprolol
    A) Sotalol
    (this multiple choice question has been scrambled)
  23. Which of the following beta blockers is the best choice for managing an arrhythmic episode during a surgical operation procedure?

    A) Esmolol
    B) Metoprolol
    C) Sotalol
    D) Propranolol
    A) Esmolol
    (this multiple choice question has been scrambled)
  24. Which of the following antiarrhythmic drugs reduces both pacemaker current and L-type ca current?

    A) Verapamil
    B) Flecainide
    C) Ibutilide
    D) Metoprolol
    D) Metoprolol
    (this multiple choice question has been scrambled)
  25. Which of the following antiarrhythmic drugs has the least AV block effect?

    A) Lidocaine
    B) Verapamil
    C) Adenosine
    D) Metoprolol
    A) Lidocaine
    (this multiple choice question has been scrambled)
  26. Which of the following antiarrhythmic drugs may produces reverse use-dependent action?

    A) Adenosine
    B) Lidocaine
    C) Dofetilide
    D) Verapamil
    C) Dofetilide
    (this multiple choice question has been scrambled)
  27. Which of the following is a wanted pharmacological action of antiarrhythmic drugs

    A) Reverse use-dependent action
    B) Inactivating GIRK current (IK, ACh, ADO)
    C) Reducing intracellular Ca overload
    D) Stimulating ectopic foci
    C) Reducing intracellular Ca overload
    (this multiple choice question has been scrambled)
  28. Which of the following is an unwanted pharmacological action of antiarrhythmic drugs?

    A) Blocking reentry pathway
    B) Inhibiting ectopic foci
    C) Reducing intracellular Ca2+ overload
    D) Enhancing EAD or DAD activity
    D) Enhancing EAD or DAD activity
    (this multiple choice question has been scrambled)
  29. Which of the following are paired correctly?

    A) Dronedarone / Reduction of refractory period
    B) Use-dependent blockade in diseased or hyperpolarized heart tissue
    C) Blocking reentry pathway
    D) Ibutilide / Activation of slow sodium current
    D) Ibutilide / Activation of slow sodium current
    (this multiple choice question has been scrambled)
  30. Which of the following is not paired correctly?

    A) Dronedarone / disturbance of thyroxine metabolism
    B) Verapamil / AV block
    C) Procainamide / Long QT symdrome
    D) Amiodarone / pulmonary fibrosis
    A) Dronedarone / disturbance of thyroxine metabolism
    (this multiple choice question has been scrambled)
  31. Which of the following is not a wanted pharmacological action of antiarrhythmic drugs

    A) Activating GIRK current (IK,Ach, ADO)
    B) Blocking reentry pathway
    C) Reverse-use dependent action
    D) Use-dependent action
    C) Reverse-use dependent action
    (this multiple choice question has been scrambled)
  32. Which of the following statements is FALSE regarding antiarrhythmics

    A) They may directly act on ion channel proteins
    B) They may increase the excitability of ventricular myocytes
    C) They may act on through G-protein coupled receptors and affect ion channel activities
    D) They may alter the refractoriness of the myocardium
    B) They may increase the excitability of ventricular myocytes
    (this multiple choice question has been scrambled)
Author:
ebmalonzo
ID:
316346
Card Set:
Antiarrythmics
Updated:
2016-02-23 03:24:38
Tags:
Antiarrythmics
Folders:
Therapeutics 2 Final
Description:
IT 2 (Final): Antiarrythmics
Show Answers: