Antimicrobials

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  1. Penicillins/Cephalosporins mechanism of action
    inhibit cell wall synthesis
  2. Beta lactam drugs
    Penicillins/Cephalosporins
  3. Penicillins/Cephalosporins: Bactericidal or bacteristatic?
    Bactericidal
  4. Produced by bacteria to break down beta lactams
    beta lactamases
  5. Broad spectrum penicillins (G+ & G-)
    • ampicillin
    • amoxicillin
  6. Tetracyclines: Bactericidal or bacteristatic?
    bacteriostatic
  7. Bacteriocidal drugs:
    • Penicillins/cephalosporins
    • Aminoglycosides
    • Fluoroquinolones
    • Rifampin
    • Metronidazole
    • Trimethoprim/sulfas
  8. Bacteriostatic drugs:
    • Tetracyclines
    • Chloramphenicol
    • Macrolides
    • Lincosamides
    • Sulfonamides
  9. Tetracycline method of action
    inhibit protein synthesis
  10. Resistance to tetracyclines is from
    plasmid mediated efflux pumps
  11. Choramphenicol mechanism of action
    inhibiting protein synthesis
  12. Chloramphenicol is Bactericidal or bacteristatic?
    bacteriostatic
  13. Aminoglycosides mechanism of action
    inhibit rate of synthesis and cause misreading of mRNA
  14. Aminoglycosides: Bactericidal or bacteristatic?
    Bactericidal
  15. Obligate anaerobes are resistant to
    Aminoglycosides
  16. Used for Gram negative infections
    Aminoglycosides
  17. Has poor cell wall penetration
    Aminoglycosides
  18. Gentamicin, amikacin, neomycin, streptomycin are what kind of antimicrobial?
    Aminoglycosides
  19. Erythromycin, tilmicosin, azithromycin, clarithromycin
    Macrolides
  20. Clindamycin, lincomycin, pirlimycin
    Lincosamides
  21. Macrolides/Lincosamides: Bactericidal or bacteristatic?
    Bacteriostatic
  22. Macrolides & Lincosamides are active against
    gram-positives, aerobes, anaerobes, and mycoplasma
  23. Fluoroquinolones mech. of action
    targets DNA synthesis
  24. Fluoroquinolones: Bactericidal or bacteristatic?
    bactericidal
  25. Baytril is a
    Fluoroquinolone
  26. Fluoroquinolones have limited activity against
    anaerobes and streptococci
  27. generic names include "-floxacin"
    Fluoroquinolones
  28. ciprofloxacin is a
    Fluoroquinolone
  29. DNA damaging antibiotics (5)
    • Fluoroquinolones
    • Nitrofurans
    • Novobiocin
    • Rifampin
    • Metronidazole
  30. Novobiocin has limited use for
    gram positives
  31. Nitrofurans are
    broad spectrum, mostly topical
  32. Rifampin: Bactericidal or bacteristatic?
    bactericidal
  33. Rifampin is active against
    • gram positives
    • acidfast bacteria
  34. Metronidazole is active against
    obligate anaerobes & parasites
  35. This antimicrobial cannot be used in food animals
    Metronidazole
  36. Sulfonamides mech. of action
    competitive analogs in the synthesis of folic acid
  37. Sulfonamides are active against these specific genera of bacteria (4)
    • Actinomyces
    • Nocardia
    • Coccidia
    • Toxoplasma
  38. Sulfonamides are NOT effective against these specific genera of organisms (4)
    • Psudomonas
    • Clostridium
    • Leptospira
    • Rickettsia
  39. Vancomycin is
    bactericidal for gram-positive cocci
  40. Polymyxins are
    topical for gram negatives
  41. Bacitracin is
    topical for gram positives
  42. Carbapenems are
    atypical beta-lactams with very broad spectrum activity
  43. Active against gram positive aerobes (6)
    • Beta lactams
    • Chloramphenicol
    • Fluoroquinolones
    • Macrolides
    • Tetracyclines
    • Sulfonamides
  44. Active against gram positive anaerobes (6)
    • Beta lactams
    • Chloramphenicol
    • Macrolides
    • Metronidazole
    • Tetracyclines
    • Sulfonamides
  45. Active against gram-negative aerobes (6)
    • Aminoglycosides
    • Beta lactams
    • Chloramphenicol
    • Fluoroquinolones
    • Sulfonamides
    • Tetracyclines
  46. Active against gram-negative anaerobes (6)
    • Beta lactams
    • Chloramphenicol
    • Metronidazole
    • Tetracyclines
    • Sulfonamides
    • Macrolides
  47. Common gram-positive aerobes (7)
    • Staphylococcus
    • Streptococcus
    • Enterococcus
    • Erysipelothrix
    • Listeria
    • Bacillus
    • Corynebacterium
  48. Common gram-positive anaerobes
    • Actinomyces
    • Clostridium
    • Peptostreptococcus
  49. Common gram negative aerobes (6)
    • E. coli
    • Salmonella
    • Klebsiella
    • Pasteurella
    • Pseudomonas
    • Proteus
  50. Common gram negative anaerobes (4)
    • Bacteroides
    • Porphyromonas
    • Prevotella
    • Fusobacterium

Card Set Information

Author:
kenleyc
ID:
317056
Filename:
Antimicrobials
Updated:
2016-03-09 01:45:06
Tags:
veterinary bacteriology
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Description:
antimicrobials in veterinary bacteriology
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