Biochem 3300 - Gluconeogenesis

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  1. Important 3C compounds in gluconeogenesis
    Lactate, pyruvate and glycerol
  2. Site of gluconeogenesis
    Liver
  3. Lactose -> ??
    Glucose
  4. Key free energy changes
    • (Std, Actual)
    • Glucose + ATP = (-16.7,-33.4)
    • Fructose-6-phosphate + ATP = (-14.2,-22.2)
    • PEP + ATP = (-31.4,-16.7)
  5. Gluconeogenesis is glycolysis reversed. What steps are different?
    Glycolysis/Gluconeogenesis

    • Hexokinase/Glucose-6-phosphate
    • phosphofructokinase-1/fructose-1,6-bisphosohate
    • pyruvate kinase/(pyruvate carboxylase)(PEP carboxykinase)
  6. Gluconeogensis step 2 mechanism
    • Oxaloacetate's carbon 4 leaves, producing enol
    • Simultaneously, the ketone dephosphorylates GTP
    • PEP
  7. Pentose phosphate pathway
    • Alternative path to oxidize glucose
    • NADP+
    • NADPH prevents oxidative damage
  8. Key steps in pentose phosphate
    • 1. Oxidation (1) to intramolecular ester
    • 2. Ester hydrolysis.
    • 3. Oxidation (3) and decarboxylation
    • 4. Isomerization to aldehyde

Card Set Information

Author:
Ant
ID:
317465
Filename:
Biochem 3300 - Gluconeogenesis
Updated:
2016-03-17 02:51:44
Tags:
Biochem 3300
Folders:
Biochem 3300
Description:
Biochem 3300
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