The Pharm of Old McDonald 7

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  1. methylphenidate
    increase NE and dopamine and other catecholamine concentration in the synaptic cleft. ADHD, narcolepsy, appetite control
  2. dextroaphetamine
    • amphetamine
    • increase release and inhibit reuptake of NE and dopamine and other catecholamines, to increase the concentration in the synaptic cleft. ADHD, narcolepsy, appetite control
  3. methamphetamine
    • amphetamine
    • increase release and inhibit reuptake of NE and dopamine and other catecholamines, to increase the concentration in the synaptic cleft. ADHD, narcolepsy, appetite control
  4. haloperidol
    • antipsychotic (high-potency 1st gen)
    • block D2 dopamine receptors to increase cAMP levels, also affecting 5-HT2, alpha and H1 receptors. Schizophrenia (positive symptoms), psychosis, bipolar disorder, delirium, Tourettes, Huntington, OCD
    • highly lipid soluble (take a long time to get out of the body), prolonged QT, hyperprolactinemia(galactorrhea, oligomenorrhea, gynecomastia) neuroleptic malignant syndrome(fever, autonomic instability, rigidity, myoglobinemia[treat with dantrolene, D2 agonists(bromocriptine)]), extrapyramidal(hours to days->acute dystonia, days to months->akathisia[restlessness] and parkinsonism[bradykinesia], months to years->tardive dyskinesia[orofacial chorea][treat with benztropine, diphenhydramine, benzodiazepines], (high-potency have more EPS effects than peripheral effects), peripheral effects(dry mouth, constipation[muscarinic blockade], orthostatic hypotension [alpha1 blockade], sedation[histamine blockade])
    • try to fly high (trifluoperazine, fluphenazine, haloperidol, high potency)
    • ADAPT to EPS (hours to days->Acute Dystonia, days to months->Akathisia[restlessness] and Parkinsonism, months to years->Tardive dyskinesia)
    • Neuroleapin' on the FARM (neuroleptic malignant syndrome, fever, autonomic instability, rigidity, myoglobinemia)
  5. trifluoperazine
    • antipsychotic (high-potency 1st gen)
    • block D2 dopamine receptors to increase cAMP levels, also affecting 5-HT2, alpha and H1 receptors. Schizophrenia (positive symptoms), psychosis, bipolar disorder, delirium, Tourettes, Huntington, OCD
    • highly lipid soluble (take a long time to get out of the body), prolonged QT, hyperprolactinemia(galactorrhea, oligomenorrhea, gynecomastia) neuroleptic malignant syndrome(fever, autonomic instability, rigidity, myoglobinemia[treat with dantrolene, D2 agonists(bromocriptine)]), extrapyramidal(hours to days->acute dystonia, days to months->akathisia[restlessness] and parkinsonism[bradykinesia], months to years->tardive dyskinesia[orofacial chorea][treat with benztropine, diphenhydramine, benzodiazepines], (high-potency have more EPS effects than peripheral effects), peripheral effects(dry mouth, constipation[muscarinic blockade], orthostatic hypotension [alpha1 blockade], sedation[histamine blockade])
    • try to fly high (trifluoperazine, fluphenazine, haloperidol, high potency)
    • ADAPT to EPS (hours to days->Acute Dystonia, days to months->Akathisia[restlessness] and Parkinsonism, months to years->Tardive dyskinesia)
    • Neuroleapin' on the FARM (neuroleptic malignant syndrome, fever, autonomic instability, rigidity, myoglobinemia)
  6. fluphenazine
    • antipsychotic (high-potency 1st gen)
    • block D2 dopamine receptors to increase cAMP levels, also affecting 5-HT2, alpha and H1 receptors. Schizophrenia (positive symptoms), psychosis, bipolar disorder, delirium, Tourettes, Huntington, OCD
    • highly lipid soluble (take a long time to get out of the body), prolonged QT, hyperprolactinemia(galactorrhea, oligomenorrhea, gynecomastia) neuroleptic malignant syndrome(fever, autonomic instability, rigidity, myoglobinemia[treat with dantrolene, D2 agonists(bromocriptine)]), extrapyramidal(hours to days->acute dystonia, days to months->akathisia[restlessness] and parkinsonism[bradykinesia], months to years->tardive dyskinesia[orofacial chorea][treat with benztropine, diphenhydramine, benzodiazepines], (high-potency have more EPS effects than peripheral effects), peripheral effects(dry mouth, constipation[muscarinic blockade], orthostatic hypotension [alpha1 blockade], sedation[histamine blockade])
    • try to fly high (trifluoperazine, fluphenazine, haloperidol, high potency)
    • ADAPT to EPS (hours to days->Acute Dystonia, days to months->Akathisia[restlessness] and Parkinsonism, months to years->Tardive dyskinesia)
    • Neuroleapin' on the FARM (neuroleptic malignant syndrome, fever, autonomic instability, rigidity, myoglobinemia)
  7. thioridazine
    • antipsychotic (low-potency 1st gen)
    • block D2 dopamine receptors to increase cAMP levels, also affecting 5-HT2, alpha and H1 receptors. Schizophrenia (positive symptoms), psychosis, bipolar disorder, delirium, Tourettes, Huntington, OCD
    • highly lipid soluble (take a long time to get out of the body), prolonged QT, hyperprolactinemia(galactorrhea, oligomenorrhea, gynecomastia), peripheral effects(dry mouth, constipation[muscarinic blockade], orthostatic hypotension [alpha1 blockade], sedation[histamine blockade])(low-potency have more peripheral effects than EPS), peripheral effects, extrapyramidal(hours to days->acute dystonia, days to months->akathisia[restlessness] and parkinsonism[bradykinesia], months to years->tardive dyskinesia[orofacial chorea][treat with benztropine, diphenhydramine, benzodiazepines])
    • low thieving cheat (low potency, thioridazine, chlopromazine)
    • ADAPT to EPS (hours to days->Acute Dystonia, days to months->Akathisia[restlessness] and Parkinsonism, months to years->Tardive dyskinesia)
    • Neuroleapin' on the FARM (neuroleptic malignant syndrome, fever, autonomic instability, rigidity, myoglobinemia)
  8. chlorpromazine
    • antipsychotic (low-potency 1st gen)
    • block D2 dopamine receptors to increase cAMP levels, also affecting 5-HT2, alpha and H1 receptors. Schizophrenia (positive symptoms), psychosis, bipolar disorder, delirium, Tourettes, Huntington, OCD
    • highly lipid soluble (take a long time to get out of the body), prolonged QT, hyperprolactinemia(galactorrhea, oligomenorrhea, gynecomastia), peripheral effects(dry mouth, constipation[muscarinic blockade], orthostatic hypotension [alpha1 blockade], sedation[histamine blockade])(low-potency have more peripheral effects than EPS), peripheral effects, extrapyramidal(hours to days->acute dystonia, days to months->akathisia[restlessness] and parkinsonism[bradykinesia], months to years->tardive dyskinesia[orofacial chorea][treat with benztropine, diphenhydramine, benzodiazepines])
    • low thieving cheat (low potency, thioridazine, chlopromazine)
    • ADAPT to EPS (hours to days->Acute Dystonia, days to months->Akathisia[restlessness] and Parkinsonism, months to years->Tardive dyskinesia)
    • Neuroleapin' on the FARM (neuroleptic malignant syndrome, fever, autonomic instability, rigidity, myoglobinemia)
  9. aripiprazole
    • atypical antipsychotic
    • dopamine D2 partial agonist to increase cAMP levels, also affecting 5-HT2, alpha and H1 receptors. both positive and negative symptoms of schizophrenia, bipolar disorder, OCD, depression, mania, anxiety disorder, Tourettes
    • prolonged QT interval, less EPS and anticholinergic side effects that 1st gen antipsychotics
  10. asenapine
    • atypical antipsychotic
    • dopamine D2 antagonist to increase cAMP levels, also affecting 5-HT2, alpha and H1 receptors. both positive and negative symptoms of schizophrenia, bipolar disorder, OCD, depression, mania, anxiety disorder, Tourettes
    • prolonged QT interval, less EPS and anticholinergic side effects that 1st gen antipsychotics
  11. clozapine
    • atypical antipsychotic
    • dopamine D2 partial agonist to increase cAMP levels, also affecting 5-HT2, alpha and H1 receptors. both positive and negative symptoms of schizophrenia, refractory schizophrenia(partial agonist is a unique mechanism) bipolar disorder, OCD, depression, mania, anxiety disorder, Tourettes
    • prolonged QT interval, agranulocytosis, weight gain, less EPS and anticholinergic side effects that 1st gen antipsychotics
    • pining for weight gain (-pines cause metabolic syndrome)
  12. iloperidone
    • atypical antipsychotic
    • dopamine D2 antagonist to increase cAMP levels, also affecting 5-HT2, alpha and H1 receptors. both positive and negative symptoms of schizophrenia, bipolar disorder, OCD, depression, mania, anxiety disorder, Tourettes
    • prolonged QT interval, less EPS and anticholinergic side effects that 1st gen antipsychotics
  13. lurasidone
    • atypical antipsychotic
    • dopamine D2 antagonist to increase cAMP levels, also affecting 5-HT2, alpha and H1 receptors. both positive and negative symptoms of schizophrenia, bipolar disorder, OCD, depression, mania, anxiety disorder, Tourettes
    • prolonged QT interval, less EPS and anticholinergic side effects that 1st gen antipsychotics
  14. olanapine
    • atypical antipsychotic
    • dopamine D2 antagonist to increase cAMP levels, also affecting 5-HT2, alpha and H1 receptors. both positive and negative symptoms of schizophrenia, bipolar disorder, OCD, depression, mania, anxiety disorder, Tourettes
    • prolonged QT interval, weight gain, less EPS and anticholinergic side effects that 1st gen antipsychotics
    • pining for weight gain (-pines cause metabolic syndrome)
  15. paliperidone
    • atypical antipsychotic
    • dopamine D2 antagonist to increase cAMP levels, also affecting 5-HT2, alpha and H1 receptors. both positive and negative symptoms of schizophrenia, bipolar disorder, OCD, depression, mania, anxiety disorder, Tourettes
    • prolonged QT interval, less EPS and anticholinergic side effects that 1st gen antipsychotics
  16. quetiapine
    • atypical antipsychotic
    • dopamine D2 antagonist to increase cAMP levels, also affecting 5-HT2, alpha and H1 receptors. both positive and negative symptoms of schizophrenia, bipolar disorder, OCD, depression, mania, anxiety disorder, Tourettes
    • prolonged QT interval, weight gain, less EPS and anticholinergic side effects that 1st gen antipsychotics
    • pining for weight gain (-pines cause metabolic syndrome)
  17. risperidone
    • atypical antipsychotic
    • dopamine D2 antagonist to increase cAMP levels, also affecting 5-HT2, alpha and H1 receptors. both positive and negative symptoms of schizophrenia, bipolar disorder, OCD, depression, mania, anxiety disorder, Tourettes
    • prolonged QT interval, hyperprolactinemia(amenorrhea, galactorea, gynecomastia), less EPS and anticholinergic side effects that 1st gen antipsychotics
  18. ziprasidone
    • atypical antipsychotic
    • dopamine D2 antagonist to increase cAMP levels, also affecting 5-HT2, alpha and H1 receptors. both positive and negative symptoms of schizophrenia, bipolar disorder, OCD, depression, mania, anxiety disorder, Tourettes
    • prolonged QT interval, less EPS and anticholinergic side effects that 1st gen antipsychotics
  19. lithium
    • unkown mechanism. Mood stabilizer for bipolar disorder
    • tremor, hypothyroidism, nephrogenic DI, Ebstein anomaly, narrow therapeutic window, renal excretion (thiazides cause Li toxicity)
    • LI BI DI and I (lithium, bipolar, diabetes inspidus, hypothyroidism[iodine])
  20. buspirone
    • stimulates 5-HT(1A) receptors. Generalized anxiety disorder
    • no sedation, addiction, or tolerance! Also doesn't interfere with alcohol like barbiturates and benzodiazepines do
    • don't be anxious that the BUS will be ON time (anxiety, buspirone)
  21. SSRIs
    • fluoxetine, paroxetine, sertaline, citalopram
    • 5-HT reuptake inhibition, increasing 5-HT levels in the cleft. Depression, GAD, panic disorder, OCD, bulimia, social anxiety disorder, PTSD, premature ejaculation, premenstrual dysphoric disorder
    • GI distress, SIADH, sexual dysfunction, serotonin syndrome takes 4-8 weeks to have an effect, fewer adverse effects than TCAs
    • sertain select citizens are paralyzed by the flu (sertaline, SSRIs, citalopram, paroxetine, fluoxetine)
  22. fluoxetine (class)
    • SSRI
    • sertain select citizens are paralyzed by the flu (sertaline, SSRIs, citalopram, paroxetine, fluoxetine)
  23. paroxetine (class)
    • SSRI
    • sertain select citizens are paralyzed by the flu (sertaline, SSRIs, citalopram, paroxetine, fluoxetine)
  24. sertaline (class)
    • SSRI
    • sertain select citizens are paralyzed by the flu (sertaline, SSRIs, citalopram, paroxetine, fluoxetine)
  25. citalopram (class)
    • SSRI
    • sertain select citizens are paralyzed by the flu (sertaline, SSRIs, citalopram, paroxetine, fluoxetine)
  26. SNRIs
    • venlafaxine, desvenlafaxine, duloxetine, levomilnacipran, milnacipran
    • 5-HT and NE reuptake inhibition, increase serotonin and NE levels in the cleft. Depression, GAD, diabetic neuropathy
    • HTN, stimulant effects(tachycardia, insomnia?), sedation, nausea, serotonin syndrome
    • it's a SiN to venmo/fax millions to levorage ox duels and change desvtiny (SNRIs, venlafaxine, milnacipran, levomilnacipran, duloxetine, desvenlafaxine)
  27. venlafaxine (class/special?)
    • SNRI
    • Depression, GAD, diabetic neuropathy, also for social anxiety disorder, panic disorder, PTSD, OCD
    • it's a SiN to venmo/fax millions to levorage ox duels and change desvtiny (SNRIs, venlafaxine, milnacipran, levomilnacipran, duloxetine, desvenlafaxine)
  28. milnnacipran (class/special?)
    • SNRI
    • Depression, GAD, diabetic neuropathy
    • it's a SiN to venmo/fax millions to levorage ox duels and change desvtiny (SNRIs, venlafaxine, milnacipran, levomilnacipran, duloxetine, desvenlafaxine)
  29. levomilnacipran (class/special?)
    • SNRI
    • Depression, GAD, diabetic neuropathy
    • it's a SiN to venmo/fax millions to levorage ox duels and change desvtiny (SNRIs, venlafaxine, milnacipran, levomilnacipran, duloxetine, desvenlafaxine)
  30. duloxetine (class/special?)
    • SNRI
    • Depression, GAD, diabetic neuropathy
    • it's a SiN to venmo/fax millions to levorage ox duels and change desvtiny (SNRIs, venlafaxine, milnacipran, levomilnacipran, duloxetine, desvenlafaxine)
  31. desvenlafaxine (class/special?)
    • SNRI
    • Depression, GAD, diabetic neuropathy
    • it's a SiN to venmo/fax millions to levorage ox duels and change desvtiny (SNRIs, venlafaxine, milnacipran, levomilnacipran, duloxetine, desvenlafaxine)
  32. TCAs
    • amitriptyline, nortriptyline, imipramine, desipramine, clomipramine, doxepin, amoxapine
    • 5-HT and NE reuptake inhibition, increase serotonin and NE levels in the cleft. Major depression, peripheral neuropathy, chronic pain, migraine prophylaxis
    • sedation, postural hypotension(alpha1 blockade), tachycardia, urinary retention, dry mouth, hallucinations in elderly(anticholinergic, worse with amitriptaline, so use nortriptyline), arrhythmia(Na block, tx is NaHCO3), respiratory depression, fever
    • amo doxins, I pray mine hasn't tripped a line, that would make be 3x more depressed (amoxapine, doxepin, -ipramines[imipramine, desipramine, clomipramine], -triptylines[nortriptylines, amitriptyline], TCAs)
  33. amitriptyline (class/special?)
    • TCA
    • tachycardia, urinary retention, dry mouth, hallucinations in elderly(anticholinergic effects, worse with amitriptaline, so use nortriptyline)
  34. nortriptyline (class/special?)
    • TCA
    • less tachycardia, urinary retention, dry mouth, hallucinations in elderly(anticholinergic, worse with amitriptaline, so use nortriptyline)
  35. impramine (class/special?)
    TCA
  36. desipramine (class/special?)
    TCA
  37. clomipramine (class/special?)
    • TCA
    • OCD, major depression, peripheral neuropathy, chronic pain, migraine prophylaxis
  38. doxepin (class/special?)
    TCA
  39. amoxapine (class/special?)
    TCA
  40. MAOI
    • tranylcypromine, phenelzine, isocarboxazid, selegiline
    • MAO inhibition in neurons increases levels of amines(NE, 5-HT, dopamine), to increase their levels in the cleft. Atypical depression, anxiety
    • serotonin syndrome(contraindicated with SSRIs, TCAs, St. John's wort, meperidine, dextromethorphan, cheese, wine[tyramine][wait 2 weeks for clearance of MAOI]), CNS stimulation
    • that Mao is so carazy savage that he puts trannys in a funnel (MAOB, isocarboxazid, selegiline, tranylcypromine, phenelzine)
  41. isocarboxazid (class)
    • MAOI
    • that Mao is so carazy savage that he puts trannys in a funnel (MAOB, isocarboxazid, selegiline, tranylcypromine, phenelzine)
  42. tranylcypromine (class)
    • MAOI
    • that Mao is so carazy savage that he puts trannys in a funnel (MAOB, isocarboxazid, selegiline, tranylcypromine, phenelzine)
  43. phenelzine (class)
    • MAOI
    • that Mao is so carazy savage that he puts trannys in a funnel (MAOB, isocarboxazid, selegiline, tranylcypromine, phenelzine)
  44. bupropion
    • atypical antidepressant
    • unknown mechanism, increases NE and dopamine levels in the cleft. Depression, smoking cessation
    • stimulant effects (tachycardia, insomnia), headache, seizures in anorexic/bulimic patients, no sexual side effects
  45. mirtazapine
    • alpha 2 antagonist, increasing NE and 5-HT levels, but also a potent 5-HT(2), 5-HT(3), and H1 receptor antagonist. Depression
    • sedation (may be good though), increased appetite (might be good), weight gain (appetite increase) (might be good though), dry mouth
  46. trazodone
    • blocks 5-HT2, alpha 1, and H1 receptors with weak 5-HT reuptake inhibition. Insomnia of depression (high doses needed for antidepressive effects)
    • sedation, priapism, postural hypotension
    • traZZZobone (trazodone, sedation/insomnia, priapism)
  47. verenicline
    • partial antagonist at nicotinic ACh receptor. Smoking cessation
    • wacked out dreams

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Author:
countchocula58
ID:
318292
Filename:
The Pharm of Old McDonald 7
Updated:
2016-04-05 14:35:18
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tubberly tubblish pharm pharmacology step one
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