The Pharm of Old McDonald 10

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  1. bevacizumab
    • monoclonal antibody against vascular endothelial growth factor, inhibiting angiogenesis. Solid tumors (esp colorectal, renal cell carcinoma)
    • hemorrhage, blood clots, impaired wound healing
  2. ranibizumab
    • monoclonal antibody against vascular endothelial growth factor, inhibiting angiogenesis. Neovascualr age-related macular degeneration
    • hemorrhage, blood clots, impaired wound healing
  3. erlotinib
    • epidermal growth factor recptor tyrosine kinase inhibitor. Non-small cell lung cancer
    • Rash
    • the erl of EnGland and FRance wanted to get fit, so he pandered to the cetizens (erlotinib, EGFR, gefitinib, panitumumab, cetuximab)
  4. cetuximab
    • monoclonal antibody against epidermal growth factor recptor. Stage IV colorectal cancer (wild type KRAS only!), head and neck cancer
    • Rash, hepatotoxic, diarrhea
    • the erl of EnGland and FRance wanted to get fit, so he pandered to the cetizens (erlotinib, EGFR, gefitinib, panitumumab, cetuximab)
  5. imatinib
    • tyrosine kinase inhibitor of BCR-ABL and c-kit. CML, GI stromal tumors
    • fluid retention
  6. rituximab
    • monoclonal antibody against CD-20. Non-Hodgkin lymphoma, CLL, immune thrombocytopenic purpura (ITP), RA
    • increased risk of progressive multifocal leukoencephalopathy (JC virus)
    • ri2Ximab (2X=20, CD20, rituximab)
  7. trastuzumab
    • aka herceptin
    • monoclonal antibody against human epidermal growth factor receptor 2 HER-2 (c-erbB2) (tyrosine kinase). HER-2 postivie breast and gastric cancer
    • her trashy bra makes her 2 boobs look new (trastuzumab, breast cancer, HER-2/neu)
    • heartceptin (cardiotoxicity, trastuzumab[herceptin])
  8. vemurafenib
    • small molecule inhibitor of BRAF oncogene. V600E-mutated BRAF metastatic melanoma
    • VEmuBRAFinhib (V600E-mutated BRAF inhibitor)
  9. cyclosporine
    • binds cyclophilin to inhibit calcineurin, reducing nuclear factor of activated T cells (NFAT), preventing IL-2 expression and inhibiting T cell activation. Transplant rejection prophylaxis, psoriasis, RA
    • nephrotoxicity, HTN, hyperlipidemia, neurotoxicity, gingival hyperplasia, hirsutism
    • bicyclosporine (IL-2, cyclosporine)
  10. tacrolimus
    • aka FK506
    • binds FK506 binding protein (FKBP) to inhibit calcineurin, reducing nuclear factor of activated T cells (NFAT), preventing IL-2 expression. Transplant rejection prophylaxis
    • I'll have a taco with lime and a taco without lime (IL-2 [one of each taco], tacrolimus, FK506[you could work "fucking" 5-6 times into that sentence])
  11. sirolimus
    • aka rapamycin
    • binds FK506 binding protein (FKBP) to inhibit mTOR, reducing response to IL-2, inhibiting B cell differentiation and T cell activation
    • pancytopenia, insulin resistance, hyperlipidemia, not nephrotoxic(tacrolimus and cyclosporine are)
    • kidney sirvives (not nephrotoxic, sirolimus)
    • sir olimus responds to maiden B and maiden T in the tower (sirolimus, response to IL-2[two maidens], rapamycin[maidens], B cells, T cells, mTOR[maiden tower])
  12. daclizumab
    • monoclonal antibody against IL-2 receptors. Kidney transplant
    • edema, hypertension, tremor
    • Harry Potter and the Chamber of daiquiris (basiliximab, daclizumab, IL-2R[second book])
  13. basiliximab
    • monoclonal antibody against IL-2 receptors. Kidney transplant
    • edema, hypertension, tremor
    • Harry Potter and the Chamber of daiquiris (basiliximab, daclizumab, IL-2R[second book])
  14. mycophenolate mofetil
    • reversible inhibtion of IMP dehydrogenase to prevent purine nucleotide formation, reducing B and T cell synthesis. Transplant rejection, lupus nephritis
    • GI upset, pancytopenia (CMV infection), hypertension, hyperglycemia, less nephro/neurotoxic
    • Stephen Moffat has a pure hatred of imps (mycophenolate mofetil, purine, IMP dehydrogenase)
  15. aldesleukin
    • recombinant IL-2. Renal cell carcinoma, metastatic melanoma
    • ILdes2kin (IL-2, aldesleukin)
  16. epoetin alfa
    recombinant erythropoietin. Anemias, especially with renal failure
  17. filgrastim
    • recombinant granulocyte colony stimulating factor. Bone marrow recovery
    • fill up the grans (filgramstim, granulocyte colony stimulating factor
  18. sargramostim
    • recombinant granolycte macrophage colony stimulating factor. Bone marrow recovery
    • sorta gran o stimulator (sargramostim, granolycte macrophage colony stimulating factor)
  19. romiplostim
    recombinant thrombopoietin receptor agonist. Thrombocytopenia
  20. eltrombopag
    recombinant thrombopoietin receptor agonist. Thrombocytopenia
  21. Oprelvekin
    • recombinant IL-11. Thrombocytopenia
    • Oprah livin one by one day at a time (oprelvekin, IL-11)
  22. alemtuzumab
    • monoclonal antibody against CD52. CLL, MS
    • almenactuzumab (CD 52 [weeks in a year for almenac], alemtuzumab)
  23. eculizumab
    • monoclonal antibody of complement protein C5. Paroxysmal nocturnal hemoglobinuria
    • your E Coli zoo copmlements my pig pen (C5 [E=5], eculizumab, complement, PNH[pig])
  24. natalizumab
    • monoclonal antibody of alpha4 integrin, reducing WBC adhesion. Multiple sclerosis, Chron disease
    • increased risk of progressive multifocal leukoencephalopathy in patients with JC virus
    • natali is lacking for integrity and her brain is filled with junk (natalizumab, alpha4 (for), integrin, leukoencephalopathy, JC virus)
  25. denosumab
    • monoclonal antibody targetting RNAKL to inhibit osteoclast maturaiton. Osteoporosis
    • dem bones sumab (denosumab, osteoporosis)
  26. bethanechol
    • direct agonist of ACh receptors. Posteroperative ileus, neurogenic ileus, urinary retention
    • bathroomanechol (ileus, urinary retention, bethanechol)
  27. edrophonium
    • anticholinesterase used to increase ACh levels. Myasthenia gravis diagnosis
    • exacerbation of COPD, asthma, peptic ulcers
  28. neostigmine
    • anticholinesterase used to increase ACh levels without CNS penetration. Postoperative ileus, neurogenic ileus, urinary retention, myasthenia gravis, postoperative reversal of blockade
    • exacerbation of COPD, asthma, peptic ulcers
  29. physostigmine
    • anticholinesterase used to increase ACh levels with CNS penetration. Anitcholinergic toxicity (tertiary amines can cross BBB)
    • physiostigmine (return to physio, physostigmine)
    • exacerbation of COPD, asthma, peptic ulcers
  30. pyridostigmine
    • anticholinesterase used to increase ACh levels without CNS penetration, long-acting. Myasthenia gravis (long-acting)
    • exacerbation of COPD, asthma, peptic ulcers
  31. atropine
    muscarinic antagonist. Bradycardia treatment, eye dilation
  32. homatropine
    muscarinic antagonist. Bradycardia treatment, eye dilation
  33. tropicamide
    muscarinic antagonist. Bradycardia treatment, eye dilation
  34. benztropine
    • muscarinic antagonist, CNS acting. Parkinson disease, acute dystonia
    • park my benz (parkinson, benztropine)
  35. glycopyrrolate
    muscarinic antagonist, GI and respiratory. Preoperative airway secretion reduction, peptic ulcers, drooling
  36. hyoscyamine
    muscarinic antagonist, GI acting. Irritable bowel syndrome
  37. dicyclomine
    muscarinic antagonist, GI acting. Irritable bowel syndrome
  38. oxybutynin
    muscarinic antagonist, GU acting. Overactive bladder (urgency and bladder spasm reduction)
  39. solifenacin
    muscarinic antagonist, GU acting. Overactive bladder (urgency and bladder spasm reduction)
  40. tolterodine
    muscarinic antagonist, GU acting. Overactive bladder (urgency and bladder spasm reduction)
  41. scopolamine
    muscarinic antagonist, CNS acting. Motion sickness
  42. dobutamine
    beta 1 agonist more than beta 2 and alpha, increasing hear contractility with mild heart rate increase. Heart failure, cardiac stress testing
  43. dopamine
    agonist at dopamine receptors 1 and 2 more than beta and alpha receptors. Lower doses have more beta effects (ionotrophic and chronotrophic), used for unstable bradycardia, HF. Higher doses have more alpha effects, shock
  44. isoproterenol
    • equal agonist at beta 1 and beta 2. Electrophysiologic evaluation of tachyarrhythmia
    • worsened ischemia
  45. midodrine
    • agonist at alpha 1. Autonomic insufficiency, postural hypotension
    • worsened supine hypertension
  46. norepinephrine
    agonst at alpha 1 more than alpha 2 more than beta 1. Hypotension, septic shock
  47. clonidine
    • alpha 2 agonist, reducing sympathetic output. Hypertensive urgency, ADHD, Tourette syndrome
    • CNS depression, bradycardia, hypotension, respiratory depression, misosis
  48. guanfacine
    • alpha 2 agonist, reducing sympathetic output. Hypertensive urgency, ADHD, Tourette syndrome
    • CNS depression, bradycardia, hypotension, respiratory depression, misosis
  49. alpha methyldopa
    • alpha 2 agonist, reducing sympathetic output. Hypertension in pregnancy
    • direct coombs hemolysis, induced lupus
  50. phenoxybenzamine
    • irreversible alpha 1 and alpha 2 (equal) blockade. Used preoperatively in pheochromocytoma to prevent hypertensive crisis
    • orthostatic hypotension, reflex tachycardia
    • ephen bloxy benzamine (even alpha, block)
  51. phentolamine
    • reversible alpha 1 and alpha 2 (equal) blockade. Used in hypertensive crisis from tyramine and MAOIs
    • orthostatic hypotension, reflext tachycardia
    • ephen toll amine (even, alpha, block)
  52. fomepizole
    inhibitor of alcohol dehydrogenase, ethanol/methanol not broken down to acetaldehyde/formaldehyde. Ethanol/methanol poisoning

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Author:
countchocula58
ID:
318295
Filename:
The Pharm of Old McDonald 10
Updated:
2016-04-06 16:22:42
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