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Background of Marburg Virus
- In 1967, 3 lab workers became ill after processing monkey organs in Marburg, Germany.
- 3 got a severe fever--> led to a small localized outbreak, 32 people caught it, and 7 died
Relation of ebola and marburg
in the same family
ebola is also pretty closely related to rabies, measles, and mumps, as well as a distantly related flu virus
Capsid of filviruses
Diameter determined by nucleocapsid and structure
filamentous envelope particles and a helical nucleocapsid
Genome of filovirus
linear, ssRNA, negative sense, one segment
seven genes transcribed by viral RNA pol
One gene makes one RNA, which makes one single protein
Genes and protins
Most proteins are packaged in the virion
- Nucleocapsid (NP)
- RNA polymerase cofactor (VP35)
- Matrix protein (VP 40)
- Envelope glycoproteins (GP, cleavd into GP1 and GP2)
- Minor nucleocapsid protein (VP30)
- Membrane protein (VP24)
- RNA polymerase (L)
Ebola makes additional secreted glycoproteins (sGP)
Virion of the virus
the genome is not infectious by itself because it is negative sense
Viruses and hosts?
These viruses are __. The outbreak pattern is probably from __ .
Marburg has one species
Ebola has five species
fruit bats to primates
Infections with __ and __ viruses cause __.
Major symptoms are __, __, __, __, and __.
Lethality can be __.
Local outbreaks are often followed by __.
Marburg and Ebola viruses; severe hemorrhagic fever
fever, hemorrhages, liver dysfunction, intravascular coagulation, and shock
high (up to 90%)
no treatment or licensed vaccine
lengthy absence of disease
Marburg and EBola viruses are __
sporadically emerging viruses that cause severe often fatal disease
OUtbreak of Marburg?
first outbreak of Marburg virus was in Marburg and Germany in 1967
Outbreak of Ebola
first outbreak in Zaire and Sudan in 1976
Filoviruses are related to __ and __.
They cause __.
paramyxoviruses and rhabdoviruses
__ is the only filovirus that has not been associated with human disease.
Filovirus genomes contain __ in a __.
All genes are flanked by __ that signal __, __, and __.
- conserved sequences
- termination, polyadenylation, and reinitiation
There are similarities to other mononegaviruses, such as the __.
the __ is at the very end.
There is a similar method of trascription, where __; and, each time, at the end of the gene, the polymerase __ so that you get more products of the proteins at the __ and
- NP protien
- single entry down at the 3'
- falls off