Basic Bio-pharmaceutics

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Basic Bio-pharmaceutics
2010-08-30 16:50:20
Basic Biopharmaceutics

Chapter 10
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  1. site of action
    the location where an administered drug products an effect
  2. receptor
    the cellular material located at the site of action that interacts with the drugs
  3. selective (action)
    the characteristic of drug that makes its action specific to certain receptors and tissues
  4. agonists
    drugs that activate receptors to accelerate or slow normal cellular function
  5. antagonists
    drugs that bind with receptors but do not activate them. they block receptor action by preventing other drugs or substances from activating them.
  6. Biopharmaceutics
    the study of the factors associated with drug products and physiological processes and the resulting systematic concentration of drugs
  7. minimum effective concentration (MEC)
    the blood concentration needed for a drug to produce a response
  8. onset of action
    the time MEC is reached and response occurs
  9. therapeutic window
    a drug's blood concentration range between MEC and MTC
  10. Minimum toxic concentration (MTC)
    the upper limit of the therapeutic window. drug conentrations above the MTC increase risk of undesired effects.
  11. Duration of action
    the time drug concentration is above MEC
  12. Disposition
    a term sometimes used to refer to all of the ADME processes together
  13. elimination
    the processes of metabolism and excretion
  14. passive diffusion
    the movement of drugs from an area of higher concentration to lower concentration
  15. lipoidal
    fat-like substance
  16. hydrophobic
    water repelling; cannot associate with water
  17. hydrophilic
    capable of associating with or absorbing water
  18. active transport
    the movement of drugs from an area of lower concentration to an area of higher concentration. cellular energy is required.
  19. absorption
    the movement of a drug from a dosage formulation to the blood
  20. gastric emptying time
    the time a drug will stay in the stomach before it is emptied into the small intestine
  21. protein binding
    the attachment of a drug molecule to a plasma or tissue protein, effectively making the drug inactive but also keeoing it within the body
  22. complexation
    when different molecules associate or attach to each other
  23. metabolite
    the substance resulting from the body's transformation of an administered drug
  24. enzyme
    a complex protein that catalyzes chemical reactions
  25. enzyme induction
    the increase in hepatic enzyme activity that results in greater metabolism of drugs
  26. enzyme inhibition
    the decrease in hepatic enzyme activity that results in reduced metabolism of drugs
  27. enterohepatic cycling
    the transfer of drugs and their metabolites from the liver to the bile in the gallbladder then into the intestine and then back into circulation
  28. first-pass metabolism
    the substantial degradation of an orally administered drug caused by enzyme metabolism in the liver before the drug reaches the systematic circulation
  29. nephron
    the functional unit of the kidneys
  30. glomercular filteration
    the blood filtering process of the nephron
  31. pharmaceutical equivalent
    drug products that contain identical amounts of the same active ingredient in the same dosages form
  32. pharmaceutical alternative
    drug products that contain the same active ingredient but not necessarily in the same salt form amount or dosage form
  33. therapeutic equivalent
    pharmaceutical equivalents that produce the same effects in patients
  34. bioavailability
    the relative amount of an administered dose that reaches the general circulation and the rate at which this occurs
  35. bioequivalency
    the comparison of bioavailibilty between two dosage forms