Microbiology - 0406 - Antimicrobial II

Home > Preview

The flashcards below were created by user akhan on FreezingBlue Flashcards.


  1. Bacteriostatic agents are usually _____ that bind to _____. Eg.
    • protein inhibitors
    • the ribosome
    • •  Tetracycline - binds reversibly to the ribosome.
  2. Bacteriocidal agents bind tightly to the cellular target. Eg.
    •  Streptomycin-binds irreversibly to the ribosome.
  3. Bacteriolytic
    • An agent that kills and lysis the cell.
    • •  Usually cell wall inhibitors and detergents.
    • •  Ampicillin - inhibits cell wall synthesis and causes cells lysis.
  4. Measurement of antibiotic sensitivity
    • MIC
    • MBC
  5. MIC: Minimal Inhibitory Concentration
    The lowest concentration of agent that completely inhibits growth.
  6. MBC - Minimal Bactericidal Concentration
    The lowest concentration of an agent that will kill the bacteria.
  7. Alexander Fleming
    • Discovery of Penicillin (1929)
    • father of antibiotics
  8. Lysozymes
    Glycoside hydrolases, enzymes that damage bacterial cell walls by cleaving 1,4-beta-linkages between N-acetylmuramic acid and N-acetylglucosamine (NAG) in a peptidoglycan.
  9. Inhibitors of Cell Wall Synthesis
    • Beta-lactam antibiotics
    • Account for half of the antibiotics used
  10. Antimicrobial Drug Resistance
    • Drug uptake (permeability) and efflux pump (transport)
    • Target modification (structure/pathway/overproducing)
    • Antibiotic / drug modification
  11. Bacteriocidal, bacteristatic, bacteriolytic
    • kill (does not affect the total count)
    • inhibit the growth
    • kill and lyse

Card Set Information

Author:
akhan
ID:
319076
Filename:
Microbiology - 0406 - Antimicrobial II
Updated:
2016-05-13 21:28:29
Tags:
microbiology
Folders:
microbiology
Description:
Microbiology - 0406 - Antimicrobial II
Show Answers:

Home > Flashcards > Print Preview