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What are the Characteristics of IgG?
- 76% of serum concentration.
- Found in Plasma, Interstitial fluids
- Crosses the placenta.
- Resonsible for secondary immune response.
What are the Characteristics of IgA?
15% of serum concentration.
Lines mucous membranes and protects body surfaces.
Found in body secretions, (tears,saliva,breast milk, colostrum.)
What are the Characteristics of IgM?
- 8% of serum concentration.
- Responsible for primary immune response.
- Forms Antibodies to ABO blood antigens.
Found in Plasma
What are the Characteristics of IgD?
1% fo serum concentration.
Present on lymphocyte surface,
Assistsin differentiation of B lymphocytes.
Found in Plasma
What are the Characteristics of IgE?
- 0.002% of serum concentration.
- Causes symptoms of Allergic reactions.
Found in Plasma and Interstitial fluids.
These cells differentiate into Plasma cells when activated and the plasma cells produce antibodies.
These cells migrate from the bone marrow to the Thymus.
They compose 70-80% of circulating lymphocytes.
These cells are also involved in cell mediated immunity.
Made up of large lymphocytes with numerous granules in their cytoplasm.
They do not require sensitization to generate.
Natural killer Cells.
What are dendritic cells?
- They have an atypical shape with extensive dendrtic processes that form and retract.
- They capture antigens and transport them till they meet a Tcell with a specificity for that antigen.
- They are important in activating the immune response.
- location; skin (called Langerhaans cells), linings of
- nose, stomach and intestines.
what is humoral immunity?
- It consists of antibody-mediated immunity.
- The B cells after exposure to an antigen, will be activated to produce antibodies. IgG,M.A etc.
- This is the primary immune response 4-8 days. IgM is released first, followed by IgG.
- Some mature B cells will be left behind as memory cells to start a secondary immune response
- if exposure to the same antigen occurs again.
What is Cell-Mediated Immunity?
this is Immune response that is initiated by specific antigen recognition by T cells.
Protects against viruses (intracellular)
Important in Graft rejection, chronic infectious agents like tuberculosis and fungal infections.
what happens when the immune system overreacts?
Hypersensitivity disorders( when the body fails to recognize its own proteins and attacks them) leading to autoimmune diseases.