Card Set Information
Inflammation Section Part
Definitions and descriptions from Inflammation notes Part 1
Signs of inflammation
heat, redness, swelling, pain and disturbed function.
Some believe that loss of appetite is also a sign.
What is the first response to injury
vasoconstriction followed by dilation and often edema
What is poleax (rouleaux)?
RBC form stacks which slows the blood.
This is caused by edema and vasoconstriction
What is margination and Pavementing?
WBCs that stick to the cell wall.
Facilitated by adhesion molecules
What are the mediators of inflammation?
Arachiadonic acid derviatives
Released from platelets, mast cells, and basophils
Derived from Hageman Factor (Factor XII)
Proteins that result in vasodilation, chemotaxis, and membrane destruction (MAC)
Complement sequence is C1, C4, C5, C6, C7, C8, C9
Activated by antigen-antibody reactions
Alternate complement pathway - older - yeast cell walls and endotoxin can activate
Lectin pathway - the binding of lectins to carbohydrates on bacteria activates this pathway
Includes 2 pathways derived from phospholipids of cell membranes
Steroids block production of arachidonic acid
Aspirin inhibits cycloxygenase pathways which produce prostoglandins which cause vasodilation and thromboxane
Lipoxygenase pathway leads to leukotrines which leads to chemotaxis and increased vascular permeability