Immuno Cytokines

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Anonymous
ID:
32044
Filename:
Immuno Cytokines
Updated:
2010-08-31 12:39:23
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UTDB Immunology
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UTDB Immunology
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  1. Inhibits viral replication
    Innate response to viral infections
    Stimulates development of Th1
    Increases expressin of MHC Class 1
    Type 1 Interferon
  2. -B cell differentiation
    -IgA
    -Growth and differentiation of eosinophils
    IL-5
  3. -Inhibits proliferation and differentiation of T cells
    -Inhibits activation of macrophages
    TGF-Beta
  4. -Promotes proliferation and differentiation of Immune cells
    -Apoptosis of Ag-activated T cells
    IL-2
  5. -B-cell isotype switching to IgE
    -Inhibits IFN-Gamma from activating macrophages
    -Development of TH-2 cells
    IL-4
  6. -Proliferation of plasma cells --> Ab
    IL-6
  7. -Acts like TNF
    -Activates T cells
    -Inflammation
    IL-1
  8. -Induction of IL-1 production by macrophages
    -Apoptosis of some cell types
    -Recruitment and activation of neutrophils and monocytes to sites of infection
    -Stimulates endothelial cells to express adhesion molecules and chemokines
    TNF
  9. -Promotes TH-1 differentiation
    -Inhibit TH-2 differentiation
    -Principle macrophage activating enzyme
    -B cell isotype switching
    -Inflammation and Anti-viral
    IFN-Gamma
  10. Stimulates leukocyte movement
    Chemokines
  11. Chemotaxis
    IL-8
  12. -Inhibit MHC Class II on macrophages
    -Inhibits macrophages from making IL-12 and TNF
    -Inhibits co-stimulators
    -Immunosuppression (anti-inflammatory)
    IL-10
  13. -Secretion of IFN-Gamma by NK and T cells
    -Increase NK and CD8 T cells
    -Differentiation of CD4 (TH1) T cells
    -Mediates early innate immunity
    -Induces cell-mediated immunity
    IL-12
  14. 30% homologous to TNF
    -Activates endothelial cells and neutrophils
    Lymphotoxin (LT)
  15. -Enhances immunogenecity
    -Required for vaccines
    Adjuvant
  16. Ag that is not an immunogen. But if attached to an immunogenic molecule makes it an immunogen.

    -An Ag that requires a carrier molecule to stimulate and immune response.
    Hapten
  17. Complement Fragments:

    Cell Lysis
    Viral Neutralization
    MAC
  18. Complement Fragments:

    Inflammatory Response
    C3a, C4a, C5a, C3c
  19. Complement Fragments

    Opsonization
    C3b, C4b
  20. Complement Fragments:

    Solubilization + Clearance of immune complex
    C3b
  21. Alternative Complement Pathways
    • -C3b-Bb
    • -Innate Immunity (Faster - does not require Ab)
  22. Extravasation Steps
    • 1. Rolling Adhesion
    • 2. Tight Binding
    • 3. Diapedesis
    • 4. Migration
    • 5. Phagocytosis

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