IIIb drug formulary

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  1. phenobarbitol, Luminal
    • anticonvulsant barbituate
    • binds to barbituate receptor on GABA and potentiate activity
    • causes sedation, hepatotoxicity
  2. potassium Bromide
    • anticonvulsant
    • hyperpolarizes neurons through Cl channels to increase seizure threshold
    • hard to manage dose, usually not single agent
  3. Diazepam, Valium
    • benzodiazepine, anticonvulsant
    • potentiates GABA (gamma2)
    • benzodiazepine
  4. levetiracetam, Keppra
    • anticonvulsant
    • binds to synaptic vesicle protein, stops neurotransmitter release
    • ataxia, anorexia
  5. phenytoin, Dilantin
    • anti-epileptic agent
    • binds to voltage-activated Na channels to limit repetitive firing (use-dependent)
    • gingival hyperplasia, hirsutisim, tolerance develops quickly (p450)
  6. Metronidazole, Flagyl
    • nitroimidazole antimicrobial
    • disrupts DNA synthesis
    • neuro, lethargy, weakness, neutropenia, hepatotoxicity, hematuria, nausea, VDA
  7. clavulanic acid, ticarcillin, Timentin
    • antibacterial
    • renally-excreted antibiotic (pencillin with beta lactamase) for gram negative anaerobes. ¬†Disrupts DNA in bacteria
  8. lactulose, Enulose, Constulose, Generlac
    • laxative
    • broken down into acids by bacteria in intestines, acidifies intestinal contents to trap and draw ammonia from bloodstream to prevent hepatic encephalopathy
    • flatulance, cramping, dehydration
  9. amoxicillin/clavulanic acid, Clavamox
    • antibiotic
    • bactericidal aminopenicillin with beta-lactamase inhibitor. ¬†Disrupts DNA in bacteria
    • VDA, neurotoxicity, elevated liver enzymes, tachypnea, dyspnea, edema, tachycardia
  10. ursodeoxycholic acid, Actigall
    • bile acid
    • suppresses hepatic synthesis and secretion of cholesterol, decreases intestinal absorption of cholesterol, increases bile flow, reduces hepatotoxic effects of bile salts, reduces inflammation and fibrosis
  11. Insulin, Humalog, Humalin
    • polypeptide hormone
    • pancreatic hormone treating DKA, DM and adjunct in hyperkalemia
    • hypoglycemia, insulin-induced hyperglycemia, insulin antagonism/resistance
  12. L-deprenyl, Anipryl
    • MAO-beta inhibitor
    • metabolizes dopamine to stop inhibition of ACTH
    • can cause VDA, CNS (restlessness, repetitive motion, lethargy), salivation, diminished hearing, pruritis, licking, shivers/trembles/shakes
  13. ketoconazole, Nizoral
    • azole antifungal
    • oral fungistatic, reversible inhibitor of steroidogenesis (block P-450 enzymes)
    • VDA, hepatic toxicity, thrombocytopenia, reversible lightening of haircoat, transient suppression of gonadal and adrenal steroid synthesis, reduces testosterone synthesis
  14. mitotane, o,p'DDD, Lysodren
    • antineoplastic
    • adrenal cytotoxic (progressive necrosis of zona fasciculata and zona reticularis, aldosterone okay)
    • lethargy, ataxia, weakness, VDA, liver changes
  15. trilostane, Vetoryl
    • inhibits 3-beta hydroxysteroid dehydrogenase, reduces cortisol, aldosterone and androgens
    • lethargy, inappetence, vomiting, electrolyte abnormalities, diarrhea, hydroadrenocorticism, death
  16. prednisone
    corticosteroid with minor mineralcorticoid activity
  17. GnRH
  18. PGF2alpha, dinoprost
  19. ceftiofur sodium, Naxcel
  20. penicillin, Permapen
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IIIb drug formulary
2016-09-01 14:58:08

IIIb drug formulary
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