MBOD - Cellular Environment
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What is the volume (in liters) of the total body water?
What is the volume of extracellular fluid (in liters)? Intracellular fluid?
- Extracellular - 15 L
- Intracellular - 25 L
What is the volume (in liters) of interstitial fluid? Blood?
- Interstital fluid - 10 L
- Blood - 5 L
Name 5 properties of water
- 1) Polar
- 2) Good solvent for hydrophilic molecules
- 3) High heat capacity
- 4) high heat of evaporation
- 5) high dialectric constant
What is the shape of a water molecule?
What allows water to form hydrogen bonds?
Its dipolar nature
What secondary protein structures are hydrogen bonds involved in?
What is a hydrophobic interaction?
When hydrophobic molecules are placed together in a polar solvent they will congregate due to entropic reactions.
What does it mean to be amphipathic?
When molecules have both hydrophobic and hydrophillic regions. Ex - fatty acid
What has a hydrophobic core and a hydrophilic charged surface?
What part of a plasma membrane would an intergral membrane proteins have hydrophobic interactions with? Hydrophilic?
- Hydrophobic - area within the lipid membrance
- Hydrophillic - the area in the cytosol and cytoplasm
What happens to the strength of the ionic bonds when ions are put in a polar solution?
The strength decreases. The dialectric constant goes up with polarity thus the force goes down.
What is a van der waals force?
Locally induced dipoles by migrating charged particles that causes transient interactions between molecules. The balance between + and - dipoles result in a maximum contact distance for the forces.
What is a strong chemical reaction?
- Carbon bonds
- Covalent bonds
What are some examples of weak chemical reactions?
- Hydrogen bonds
- Hydrophobic interactions
- ionic interactions, van der waals
What maintains the body's pH??
- Lungs dispose of CO2
- Buffers ex - bicarbonate
- Kidneys excrete ammonium and phosphate
What does the strength of an acid depend on?
Which dissociate more - strong acids or weak acids?
What is the concentration of H+ and bicarbonate in the body? What is Kw?
- H+ - 10-7Bicarbonate - 10-7Kw - 10-14
What is the pH equation?
pH = -log(H+)
What is Kd?
Kd is the dissassociation constant of acid. (products / reactants). The higher the Kd the stronger the acid.
What is pKa?
-log(Ka), where Ka is the diassociation constant of the acid
What controls the pH in the body primarily?
The carbonic anhydrase reaction in the lungs
What is the point on a titration curve where the acid is equivalent to the base?
Do acids or bases have a higher pKa?
in a polyprotic acid titration curve what is the point of electroneutrality called?
What is the henderson-hasselbach equation?
pH-pK + log (base / acid)
What is the henderson hasselbach equation for the bicarbonate buffer system?
ph - 6.1 + log (HCO3- / 03pCO2)
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