non-opioid pharmacology

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  1. gabapentin
    • anticonvulsant
    • calcium channel blocker
    • most effective for C fiber mediated pain
    • also helpful for central sensitization
    • adverse effects: dose dependent dizziness, ataxia, sedation, cognitive/memory deficits, peripheral edema
    • precautions: pregnancy, CHF, volume overloaded patients
  2. pregabalin
    • anticonvulsant
    • calcium channel blocker
    • most effective for C fiber mediated pain
    • also helpful for central sensitization
    • adverse effects: dose dependent dizziness, ataxia, sedation, cognitive/memory deficits, peripheral edema
    • precautions: pregnancy, CHF, volume overloaded patients
  3. carbamazepine
    • anticonvulsant
    • sodium channel blocker
    • most effective for A delta fiber pain
    • adverse effects: dose dependent dizziness, ataxia, sedation, cognitive/memory deficits, electrolyte abnormalities, liver toxicity, blood dyscrasias, rash, blurred / double vision
    • precautions: elderly, liver dz or bone marrow dz
  4. lamotrigine
    • anticonvulsant
    • sodium channel blocker
    • most effective for A delta fiber pain
    • adverse effects: dose dependent dizziness, ataxia, sedation, cognitive/memory deficits, electrolyte abnormalities, liver toxicity, blood dyscrasias, rash, blurred / double vision
    • precautions: elderly, liver dz or bone marrow dz
  5. duloxetine
    • antidepressant
    • SNRI
    • enhance the dampening effect of the inhibitory descending pathway
  6. milnacipran
    • antidepressant
    • SNRI
    • enhance the dampening effect of the inhibitory descending pathway
  7. sumatriptan
    • triptans
    • agonist for 5-HT1B (blood vessel) and 5-HT1D (perivascular trigeminal nerve terminals) receptors
    • adverse effects: serotonin syndrome, chest pain/pressure, dizziness or vertigo, tingling, nausea, increase blood pressure
  8. zolmitriptan
    • triptans
    • agonist for 5-HT1B (blood vessel) and 5-HT1D (perivascular trigeminal nerve terminals) receptors
    • adverse effects: serotonin syndrome, chest pain/pressure, dizziness or vertigo, tingling, nausea, increase blood pressure
  9. baclofen
    • spasmolytics
    • GABA-B receptor agonist, causes hyperpolarization of motor neurons
  10. tizanidine
    • spasmolytics
    • centrally acting α2 agonist inhibits activation of motor neurons
  11. diazepam
    • spasmolytic agent
    • BZD/GABA-A receptor agonist, increases pre-synaptic inhibitory activity of GABA
  12. Dantrolene
    • spasmolytic agent
    • prevents CA release from SR when muscle contracts

Card Set Information

Author:
jboi
ID:
323396
Filename:
non-opioid pharmacology
Updated:
2016-09-20 23:03:26
Tags:
MOHD4 pharmacology nonopioid
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Description:
MOHD4 lecture 54
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