PCP

Card Set Information

Author:
LT24
ID:
32391
Filename:
PCP
Updated:
2010-09-02 02:22:07
Tags:
glutamate
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Description:
lecture #9
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  1. Phencyclidine
    • Dissociative anaesthetic
    • Parke Davis 1950
    • Withdrawn from human use in 1965
    • Related to Ketamine
    • Illicit use
    • San Francisco 1967
    • Cheap, distributed by crips
  2. Low dose effects
    Alcohol-like effect
  3. Moderate dose effects
    • Distortion of space and time, psychotic reactions
    • Anaesthetic and analgesic
    • Blank stare, amnesia, mutism
  4. High dose effects
    • Model of acute schizophrenia
    • Last up to 1-7 days
    • Sometimes violent, abusive behavior
  5. Overdose
    Respiratory depression/seizures
  6. Reinforcing effects
    • Readily self-adminstered in animals
    • To point of intoxication
    • Modest tolerance
    • Addiction and withdrawal
  7. 2 distinct binding sites
    • Sigma site -> generalizes with benzomorphans
    • PCP site -> part of NMDA receptor
  8. Glutamate
    • ubiquitous excitatory transmitter
    • depolarizes virtually all cells
    • primary transmitter for fast excitatory signaling
  9. Glutamate receptors
    • Ionotropic
    • Non-NDMA -> AMPA and Kainate
    • NDMA -> selective binds N-methyl-D-aspartate
    • Metabotropic
  10. PCP/NMDA interaction
    • Noncompetitive antagonist at NMDA receptor
    • site inside channel -> block channel
    • Does not antagonize AMPA/kainate effect
  11. Glutamate excitotoxicity
    • too much glutamate kills the cell
    • MK-801

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