Hallucinogens

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Author:
LT24
ID:
32392
Filename:
Hallucinogens
Updated:
2010-09-02 02:22:26
Tags:
LSD phenylethylamines
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Description:
lecture #9
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  1. Common features
    • hallucinogen - illusions
    • psychotomimetic - mimic endogenous psychosis
    • phantasicum, psychedelic - mind expanding
  2. LSD family
    • indole type hallucinogens
    • similar to serotonin
    • LSD - lysergic acid diethylamide
  3. Phenylethylamines
    • Similar to catecholamines
    • mixed hallucinogenic and stimulant effects
    • mescaline
  4. LSD type hallucinogens
    • come from ergot plant
    • psilocybin and psilocin -> alkaloids in mushrooms
    • DMT: naturally occurring LSD-like substance in plants
    • Morning glory seeds -> have lysergic acid amide
    • Bufotenin -> alkaloid on toads
    • Harmine and harmaline
  5. Mescaline
    • in peyote cactus
    • mescal button
  6. methoxyamphetamines
    • synthetic derivative of mescaline
    • designer drugs
    • DOM
    • TMA
    • MDA and MDMA
  7. Major effects
    • Sensory-perceptual
    • pseudohallucinations
    • illusions
    • synesthesias
    • Psychic experiences
    • Somatic effects
  8. Mechanism of action
    • LSD and other hallucinogens are 5-HT2a postsynaptic receptor agonists
    • Only short term tolerance to LSD
    • NO withdrawal, dependence, or addiction
    • Focus on 5-HT systems b/c structurally similar

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