GI DRUGS

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  1. PROTON PUMP INHIBITORS (PPIs)
    Mechanism of action
    Side effects
    • Prilosec, Nexium, Prevacid, Protonix
    • Mechanism of action: Decrease HCL acid secretion, decrease irritation of the esophageal and gastric mucosa. 
    • Side effects: Headache, abdominal pain, nausea, diarrhea, vomiting, flatulence
  2. HISTAMINE (H2 RECEPTOR BLOCKERS)
    Mechanism of action
    Side effects
    • Tagamet, Zantac, Pepcid
    • Mechanism of action: Blocks action of histamine on the H2 receptors to decrease HCL acid secretion. Decreases conversion of pepsiongen to pepsin. Decreases irritation of the esophageal and gastric mucosa. 
    • Side effects: Headache, abdominal pain, constipation, diarrhea
  3. PHENOTHIAZINES
    Trade names: T,T,C,S,P
    Mechanism of action
    Side effects
    • Thorazine, Trilafon, Compazine, Stelazine, Phenergan
    • Mechanism of action: Block dopamin receptors that trigger N/V
    • Side effects: Dry mouth, hypotension, sedative effects, rashes, constipation.
  4. ANTIHISTAMINES
    Trade names: B,D,V,B
    Mechanism of action
    Side Effects
    Bonine, Dramamine, Vistaril, Benadryl 

    • Mechanism of action: Block histamine receptors that trigger N/V
    • Side effects: Dry mouth, hypotension, sedative effects, rashes, constipation.
  5. PROKINETIC AGENTS
    Trade names:M,R
    Mechanism of action
    Side effects
    Motilium, Reglan 

    • Mechanism of action: Inhibit action of Dopamine, increase gastric motility and emptying. 
    • Side effects: CNS side effects ranging from Anxiety - hallucinations. Extrapyramidal effects: tremor and dyskinesias 
    • Note: given 2 min slowly
  6. Serotonin (5 - HT3) Antagonists
    Trade names: Z,A,K,A
    Mechanism of action
    Side effects
    • Zofran, Anzemet, Kytril, Aloxi
    • Mechanism of action: Block action of serotonin (substance that causes N/V)
    • Side effects: Constipation, diarrhea, headache, fatigue, malaise, elevated liver function tests
  7. ANTACIDS
    Examples
    Mechanism of action
    Notes
    • Aluminum carbonate, Aluminum hydroxide, Calcium carbonate (TUMS), Magnesium oxide, Sodium Bicarbonate (alka seltzer), Sodium Citrate (Bicitra)
    • Mechanism of action: Neutralizes HCL acid
    • Notes: short lived relief, take 1 - 3 hours after meals
  8. IBD Drug Therapy 
    5 Aminosalicylates
    examples: A, P, D, C
    Action
    • Azulfidine, Penasa, Dipentum, Colazal
    • Action: Decrease GI inflammation through direct contact w/ bowel mucosa.
  9. IBD drug therapy
    Antimicrobials
    Examples: F, C, B
    Action
    • Flagyl, Cipro, Biaxin
    • Action: Prevent or treat infections
  10. IBD drug therapy 
    Corticosteroids
    Examples: P, E
    Action
    • Prednisone, Entocort 
    • Action: Decrease inflammation
  11. IBD drug therapy 
    Immunosuppresants
    Examples: I, M, C
    Action
    • Imuran, Methotrexate, Cyclosporine
    • Action: Suppress immune response
  12. IBD drug therapy 
    Biologics
    Examples: R, H, C, S
    Action
    • Remicade, Humira, Cimzia, Simponi
    • Action: Inhibit the cytokine tumor necrosis factor (TNF)

Card Set Information

Author:
geoerguera
ID:
324838
Filename:
GI DRUGS
Updated:
2016-10-23 02:05:06
Tags:
GI Drugs
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Description:
GI DRUGS
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