Systemic Pathology 2015 Archives - 3 final

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  1. x15-3-1. Secretion of parathyroid hormone is primarily influenced by which of the following factors?
    a. Oxyphil cell hypoplasia
    b. Posterior pituitary hormones
    c. Anterior pituitary hormones
    d. Ionized calcium
    e. Serum total calcium
    d
  2. 15-3-2. Which of the following agents most directly stimulates storage and formation of lipids and glycogen?
    a. Glucagon
    b. Insulin
    c. Somatostatin
    d. Splenic polypeptide
    e. Tri-iodothyronine
    b
  3. x15-3-3. Which of the following factors is the most common cause of secondary hyperparathyroidism?
    a. Parathyroid gland hyperplasia
    b. Parathyroid oxyphil adenoma
    c. Parathyroid adenocarcinoma
    d. Renal osteodystrophy
    e. Hypercalcemia
    d
  4. x15-3-4. Multiple neuromas of the oral mucosa are most likely to be associated with which of the following lesions?
    a. Carcinoids
    b. Pancreatic carcinoma
    c. Benign fibro-osseous lesions
    d. Cirrhosis
    e. Medullary carcinoma of thyroid gland
    e
  5. x15-3-5. Osteoporosis is most likely to be a consequence of which of the following diseases?
    a. Cushing’s disease
    b. Hashimoto’s disease
    c. Hypoparathyroidism
    d. McCune-Albright syndrome
    e. Erythema multiforme
    a
  6. x15-3-6. Secretion of thyroid hormones is normally primarily controlled by an agent secreted by which of the following organs?
    a. Anterior lobe of pituitary gland
    b. Posterior lobe of pituitary gland
    c. Kidney
    d. Pancreas
    e. Parathyroid gland
    a
  7. x15-3-7. Which of the following lesions is most likely to occur in the anterior midline of the neck?
    a. Branchial cleft cyst
    b. Osteoma
    c. Thyroid duct cyst
    d. Necrotizing granuloma
    e. Giant cell lesion
    c
  8. x15-3-8. Which of the following diseases is most likely to exhibit lesions that contain multinucleated giant cells?
    a. Hyperparathyroidism
    b. Hypothyroidism
    c. Gardner syndrome
    d. Addison’s disease
    e. Hyperpituitarism
    b - Hashimoto vs c?
  9. x15-3-9. Tetany is most likely to be associated with which of the following conditions?
    a. Osteosarcoma
    b. Chondrosarcoma
    c. Cushing’s disease
    d. Hypoparathyroidism
    e. Hashimoto’s thyroiditis
    d
  10. x15-3-10. Which of the following disturbances is most likely to be associated with myxedema?
    a. Elevated thyroxine and tri-iodothyronine
    b. Manic episodes
    c. Elevated thyroid stimulating hormone
    d. Proptosis
    e. Hypercalcemia
    c
  11. x15-3-11. Secretory cell hyperplasia is most likely to occur in which of the following conditions?
    a. Berry’s disease
    b. Addison’s disease
    c. Graves disease
    d. Riedel’s thyroiditis
    e. Subacute thyroiditis
    c
  12. x15-3-12. Which of the following tests is most likely to be employed to provide a definitive diagnosis of thyroid cancer?
    a. CT scan
    b. MRI scan
    c. Excisional biopsy
    d. Fine needle aspiration biopsy
    e. Ultrasound examination
    d
  13. x15-3-13. Which of the following is the most common cause of rickets and osteomalacia?
    a. Malabsorption of vitamin D
    b. Elevated calcitonin
    c. Elevated parathyroid hormone
    d. Mutations in PTEN gene
    e. Defective osteoclasts
    a
  14. x15-3-14. Which of the following diseases exhibits a lymphocytic infiltrate with lymphoid follicles?
    a. Thyroid follicular hyperplasia
    b. Thyroid papillary carcinoma
    c. Medullary thyroid carcinoma
    d. Parathyroid carcinoma
    e. Hashimoto’s thyroiditis
    e
  15. 15-3-15. Polydipsia, polyuria and polyphagia are symptoms of which of the following diseases?
    a. Acromegaly
    b. McCune-Albright syndrome
    c. Osteopetrosis
    d. Diabetes mellitus
    e. Gardner syndrome
    d
  16. x15-3-16. Hyposecretion of which of the following hormones is associated with diabetes insipidus?
    a. Growth hormone
    b. Antidiuretic hormone
    c. Follicle stimulating hormone
    d. Luteinizing hormone
    e. Melanocyte stimulating hormone
    b
  17. x15-3-17. Despite exhaustive testing, no elevated hormone production can be detected in a patient with a large pituitary gland adenoma. Which of the following is/are the symptoms that most strongly correlate with this type of tumor?
    a. Increased metabolic rate
    b. Mucocutaneous pigmented macules
    c. Headaches and visual disturbances
    d. Enlarged jaw and nose
    e. Tachycardia and elevated blood pressure
    c
  18. x15-3-18. Which of the following diseases is characterized by enlarged jaw, nose and tongue?
    a. Achondroplasia
    b. Ollier’s disease
    c. Acromegaly
    d. Graves disease
    e. Hashimoto’s disease
    c
  19. x15-3-19. Which of the following is the most common microscopic feature of pituitary adenomas?
    a. Cellular monomorphism
    b. Thick fibrous and reticular network
    c. Incomplete capsule
    d. Multicentric cellular proliferation
    e. Focal necrosis
    a
  20. x15-3-20. Which of the following lesions contains stellate reticulum?
    a. Osteoma
    b. Chondrosarcoma
    c. Pituitary adenoma
    d. Hypothalamic medullary sarcoma
    e. Craniopharyngioma
    e
  21. 15-3-21. Which of the following diseases is the most common exogenous cause of hypercorticolism?
    a. Hyperpituitarism
    b. Steroid therapy
    c. Posterior pituitary hyperplasia
    d. Aldosterone secretion
    e. Decreased renal perfusion
    b
  22. x15-3-22. Which of the following conditions is most often responsible for sodium retention, potassium excretion, and elevated blood pressure?
    a. Pituitary gland atrophy
    b. Thyroid gland necrosis
    c. Nodular adrenal hyperplasia
    d. Parathyroid carcinoma
    e. Craniopharyngioma
    c
  23. x15-3-23. Which of the following conditions is the most common cause of Addison’s disease?
    a. Massive adrenal hemorrhage
    b. Infection
    c. Neoplasia
    d. Apoptosis
    e. Autoimmune disorder
    e
  24. x15-3-24. Most pheochromocytomas arise at which of the following sites?
    a. Anterior pituitary gland
    b. Posterior pituitary gland
    c. Adrenal cortex
    d. Adrenal medulla
    e. Thyroid gland
    d
  25. x15-3-25. Which of the following diseases is most likely to be recognized on the basis of elevated urinary excretion of catecholamines and vanillylmandelic acid?
    a. Addison’s disease
    b. Multiple endocrine neoplasia syndrome
    c. Cushing’s disease
    d. Graves disease
    e. Acromegaly
    b
  26. x15-3-26. The histological designation of benign fibro-osseous lesion is applied to lesions in which of the following conditions?
    a. Osteochondroma
    b. McCune-Albright syndrome
    c. Hyperparathyroidism
    d. Gardner syndrome
    e. All of the above
    b
  27. x15-3-27. Diagnosis of which of the following diseases employs the A B C D E rule?
    a. Fibrous dysplasia
    b. Osteogenesis imperfecta
    c. Osteitis fibrosa generalisata
    d. Melanoma
    e. Paget’s disease of bone
    d
  28. x15-3-28. Which of the following diseases shows a predilection for males?
    a. Rheumatoid arthritis
    b. Gout
    c. Systemic lupus erythematosus
    d. Cholelithiasis
    e. Primary biliary cirrhosis
    b
  29. x15-3-29. Which of the following lesions is a benign tumor composed of fibroblasts and collagen?
    a. Brown tumor
    b. Desmoid tumor
    c. Lymphoma
    d. Lipoma
    e. Ewing’s sarcoma
    b
  30. x15-3-30. Which of the following tumors is most often seen in the uterus?
    a. Lipoma
    b. Fibrosarcoma
    c. Leiomyoma
    d. Brown tumor
    e. Neuroma
    c
  31. xx no time to look at ppt etc
    15-3-31. RANKL (Receptor activator of nuclear factor kappa-B ligand) is produced by which of the following cells?
    a. Osteoblast
    b. Osteocyte
    c. Preosteoclast
    d. Osteoclast
    e. All of the above
    a
  32. xx15-3-32. Which of the following agents reduces bone resorption?
    a. High levels of parathyroid hormone
    b. Osteoprotegerin
    c. High concentrations of vitamin D
    d. Corticosteroids
    e. Thyroxine
    b
  33. xx15-3-33. Which of the following diseases is caused by an inherited defect in the amino acid chains of type 1 collagen?
    a. Osteopetrosis
    b. Osteogenesis imperfecta
    c. Osteoarthritis
    d. Gardner syndrome
    e. Achondroplasia
    b
  34. xx15-3-34. The highest proportion of people with which of the following diseases exhibit visual and auditory difficulties?
    a. Cretinism
    b. Osteopetrosis
    c. Hashimoto’s disease
    d. Addison’s disease
    e. Osteoporosis
    b
  35. xx15-3-35. Which United States president suffered from Addison’s disease?
    a. Clinton
    b. Washington
    c. Jefferson
    d. Kennedy
    e. Truman
    d
  36. xx15-3-36. Which of the following diseases is most often treated with bisphosphonates?
    a. Osteoporosis
    b. Diabetes mellitus
    c. Paget’s breast disease
    d. McCune-Albright syndrome
    e.. Graves disease
    a
  37. xx15-3-37. Which of the following diseases is characterized by an abnormally wide osteoid zone around bone trabeculae?
    a. Osteoporosis
    b. Osteomalacia
    c. Hypoparathyroidism
    d. Chondroma
    e. All of the above
    b
  38. xx15-3-38. Which of the following factors is mainly responsible for brown tumors?
    a. Adrenal cortical atrophy
    b. Osteoporosis
    c. Osteogenesis imperfecta
    d. Abnormally high serum levels of calcitonin
    e. Abnormally high serum levels of parathyroid hormone
    e
  39. xx15-3-39. Which of the following blood tests is most reliable in recognition of diabetes mellitus?
    a. NTX
    b. CTX
    c. HbA1c
    d. Ionized phosphate
    e. Alkaline phosphatase
    c
  40. xx15-3-40. A patient with an inherited condition of multiple osteomas of the skull and facial bones is most likely to die from which of the following diseases?
    a. Osteosarcoma
    b. Colon cancer
    c. Paget’s disease of bone
    d. Paget’s disease of breast
    e. Diabetes mellitus
    b
  41. xx15-3-41. Which of the following histological features is required for a microscopic diagnosis of osteosarcoma?
    a. Compact bone
    b. Cancellous bone
    c. Bone marrow
    d. Osteoid
    e. Periosteum
    d
  42. xx15-3-42. Which of the following is the most likely explanation for bulging, protruded eyeballs?
    a. Diabetes insipidus
    b. Addison’s disease
    c. Hypoparathyroidism
    d. Renal osteodystrophy
    e. Graves disease
    e
  43. xx15-3-43. Café-au-lait macules are most likely to seen in individuals with which of the following conditions?
    a. Paget’s disease of bone
    b. Polyostotic fibrous dysplasia
    c. Thyrotoxicosis
    d. Multiple myeloma
    e. Solitary chondrosarcoma
    b
  44. xx15-3-44. Which of the following is the most common cause of Cushing’s disease?
    a. Atherosclerosis
    b. Small cell lung carcinoma
    c. Hypoparathyroidism
    d. Crohn’s disease
    e. Pemphigus vulgaris
    b
  45. xx15-3-45. Which of the following lesions is a malignant tumor that is most likely to occur in children below age ten?
    a. Embryonal rhabdomyosarcoma
    b. Chondrosarcoma
    c. Chondrocalcinosis
    d. Lipoma
    e. Nodular fasciitis
    a
  46. xx15-3-46. Which of the following cell types is/are most susceptible to hypoxia and ischemia?
    a. Smooth muscle cells
    b. Schwann cells
    c. Neurons
    d. Macrophages
    e. Fibroblasts
    c
  47. xx15-3-47. Cerebral infarcts are most often caused by which of the following conditions?
    a. Atherosclerosis
    b. Cowden syndrome
    c. McCune-Albright syndrome
    d. Rheumatoid arthritis
    e. Lymphoma
    a
  48. xx15-3-48. Which of the following is a benign tumor originating from nerve sheath?
    a. Schwannoma (neurilemoma)
    b. Leiomyoma
    c. Rhabdomyoma
    d. Fibroma
    e. Papilloma
    a
  49. xx15-3-49. Which of the following microscopic features is most characteristic of bacterial meningitis?
    a. Neutrophils
    b. Plasma cells
    c. Lymphocytes
    d. Granulomas
    e. Macrophages
    a
  50. xx15-3-50. The highest proportion of patients with which of the following diseases develop progressive dementia?
    a. AIDS
    b. Graves disease
    c. Reidel’s struma
    d. Fibrous dysplasia
    e. Paget’s disease of bone
    a
  51. xx15-3-51. Which of the following diseases is most likely to cause nephrolithiasis?
    a. Hyperparathyroidism
    b. Hyperthyroidism
    c. Cretinism
    d. Diabetes insipidus
    e. Addison’s disease
    a
  52. xx15-3-52. Which of the following is the most common malignant primary brain tumor in children?
    a. Medulloblastoma
    b. Lymphoma
    c. Multiple myeloma
    d. Plasmacytosis
    e. Desmoid tumor
    a
  53. xx15-3-53. Which of the following diseases is/are characterized by autosomal transmission with complete penetrance?
    a. Parkinson’s disease
    b. Huntington’s chorea
    c. Paget’s disease of bone
    d. Addison’s disease
    e. All of the above
    b
  54. xx15-3-54. Which of the following diseases exhibits degeneration of the lateral corticospinal tracts and loss of anterior horn cells, with secondary neurogenic atrophy of muscle?
    a. Multiple sclerosis
    b. Parkinson’s disease
    c. Huntington’s chorea
    d. Amyotrophic lateral sclerosis
    e. Alzheimer’s disease
    d
  55. xx15-3-55. Which of the following conditions is an acute, life-threatening skin and mucous membrane reaction characterized by extensive necrosis and detachment of the epidermis?
    a. Lichen planus
    b. Bullous pemphigoid
    c. Melanoma
    d. Toxic epidermal necrolysis
    e. Squamous cell carcinoma
    d
  56. xx15-3-56. Which of the following diseases is most likely to exhibit sharply demarcated plaques, with a silvery scaly surface, on an erythematous base, on elbows, knees, scalp, and lumbosacral areas?
    a. Bullous pemphigoid
    b. Seborrheic keratosis
    c. Psoriasis
    d. Toxic epidermal necrolysis
    e. Pediculosis
    c
  57. xx15-3-57. Which of the following agents is responsible for whitlows?
    a. Alcohol
    b. Herpes simplex virus
    c. Streptococcus pyogenes
    d. Candida albicans
    e. Epstein Barr virus
    b
  58. xx15-3-58. Which of the following agents is responsible for a disease in which severe pain persists for months after skin lesions subside?
    a. Cytomegalovirus
    b. Treponema pallidum
    c. Mycobacterium tuberculosis
    d. Herpes varicella zoster virus
    e. Mycobacterium avium
    d
  59. xx15-3-59. Which of the following agents is most likely to cause a cellulitis?
    a. Candida albicans
    b. Streptococcus pyogenes
    c. Epstein Barr virus
    d. A. actinomycetemcomitans
    e. Streptococcus mutans
    b
  60. xx15-3-60. Which of the following demographic groups are most commonly affected by osteoporosis?
    a. Young white females
    b. Postmenopausal white females
    c. Men
    d. Young black females
    e. Postmenopausal black females
    b
  61. 15-Final-1. Which of the following is the most common tumor diagnosed in the liver?
    a. Squamous cell carcinoma
    b. Metastasis
    c. Papilloma
    d. Angiosarcoma
    e. Hepatocarcinoma
    b
  62. 15-Final-2. Which of the following is the most common tumor diagnosed in the lungs?
    a. Squamous cell carcinoma
    b. Mesothelioma
    c. Adenocarcinoma
    d. Fibrosarcoma
    e. Metastasis
  63. xx15-Final-3. Multiple non-necrotizing granulomas in hard and soft tissues occurs most in which of the following conditions?
    a. Leprosy
    b. Alpha-1antitrypsin deficiency
    c. Ulcerative colitis
    d. Sarcoidosis
    e. Lobar pneumonia
    d
  64. 15-Final-4. Which of the following diagnoses is most likely to result in invasive squamous cell carcinoma?
    a. Severe epithelial dysplasia
    b. Familial adenomatous polyposis
    c. Hyperplastic polyps
    d. Systemic lupus erythematosus
    e. Pancreatic cancer
    a
  65. 15-Final-5. Gynecomastia occurs most often in which of the following conditions?
    a. Whipple’s disease
    b. Alcoholism
    c. Ulcerative colitis
    d. Crohn’s disease
    e. Tuberculosis
    b
  66. xx15-Final-6. Multiple neuromas of the oral mucosa are most likely to be associated with which of the following lesions?
    a. Carcinoids
    b. Pancreatic carcinoma
    c. Benign fibro-osseous lesions
    d. Cirrhosis
    e. Medullary carcinoma of thyroid gland
    e
  67. xx15-Final-7. Which of the following conditions is most likely to be responsible for neutrophilia?
    a. Herpetic viral infection
    b. Bacterial meningitis
    c. Allergic reaction
    d. Burkitt’s lymphoma
    e. Multiple myeloma
    b
  68. xx15-Final-8. A patient with an inherited condition of multiple osteomas of the skull and facial bones is most likely to die from which of the following diseases?
    a. Osteosarcoma
    b. Colon cancer
    c. Paget’s disease of bone
    d. Paget’s disease of breast
    e. Diabetes mellitus
    b
  69. 15-Final-9. In patients with left-sided heart failure, which of the following conditions activates the renin-angiotensin-aldosterone system, leading to retention of salt and water and worsening pulmonary edema?
    a. Chronic obstructive pulmonary disease
    b. Decreased renal perfusion
    c. Diverticulosis
    d. Gastric reflux
    e. Jaundice
  70. 15-Final-10. Which of the following is the immediate cause of chronic passive congestion of the liver (nutmeg liver)?
    a. Berry aneurysm
    b. Atherosclerosis
    c. Bronchiectasis
    d. Acute pyelonephritis
    e. Right-sided heart failure
  71. 15-Final-11. What are “heart failure cells” seen in the lungs of patients after a myocardial infarct?
    a. Type one pneumocytes
    b. Type two pneumocytes
    c. Macrophages
    d. Hypoplastic endothelial cells
    e. Mast cells
  72. 15-Final-12. Which of the following is the most likely consequence of right-sided heart failure?
    a. Ankle edema
    b. Aortic aneurysm
    c. Acute respiratory distress syndrome
    d. Idiopathic pulmonary fibrosis
    e. Cirrhosis
  73. 15-Final-13. Which of the following items occupies the core of atheromatous plaques?
    a. Collagen
    b. Smooth muscle
    c. Endothelium
    d. Lipid
    e. Troponin
  74. 15-Final-14. Following severe cardiac muscle ischemia, how long does it take for cardiac mucle damage to become irreversible?
    a. 10 seconds
    b. About one minute
    c. About one hour
    d. 12 hours
    e. 2 days
  75. 15-Final-15. Autopsy of a patient who died from an automobile accident seven weeks after a myocardial infarct is likely to reveal which of the following cardiac changes?
    a. Coagulative necrosis
    b. Fibrosis
    c. Necrotizing granulomas
    d. Hyperplastic cardiac muscle
    e. Fibrocartilage
  76. 15-Final-16. Hyaline arteriolosclerosis is characteristic of which of the following diseases?
    a. Acute respiratory distress syndrome
    b. Tuberculosis
    c. Cystic fibrosis
    d. Diabetes mellitus
    e. Wegner granulomatosis
  77. 15-Final-17. Which of the following conditions is most likely to be rapidly fatal?
    a. Angina pectoris
    b. Congestive heart failure
    c. Cardiac tamponade
    d. Mitral valve stenosis
    e. Pericarditis
  78. 15-Final-18. Autopsy of an individual who dies 2 days after a myocardial infarct is most likely to show which of the following changes?
    a. None
    b. Hyperemia
    c. Coagulative necrosis and neutrophils
    d. Granulation tissue and fibrosis
    e. Adipocyte necrosis
  79. 15-Final-19. Which of the following conditions is the most common cause of angina pectoris?
    a. Hyperemia
    b. Lymphedema
    c. Aneurysm
    d. Atrophy
    e. Ischemia
  80. xx15-Final-20. The histological designation of benign fibro-osseous lesion is applied to lesions in which of the following conditions?
    a. Osteochondroma
    b. McCune-Albright syndrome
    c. Hyperparathyroidism
    d. Gardner syndrome
    e. All of the above
    b
  81. 15-Final-21. Mitral valve prolapse occurs in which of the following conditions?
    a. Peutz Jeghers syndrome
    b. Marfan syndrome
    c. Gardner syndrome
    d. von Willebrand disease
    e. Pernicious anemia
  82. 15-Final-22. Exaggerated vasoconstriction of arteries and arterioles in the extremities is most evident in which of the following conditions?
    a. Kawasaki disease
    b. Cirrhosis
    c. Bullous pemphigoid
    d. Chronic obstructive pulmonary disease
    e. Raynaud’s phenomenon
  83. 15-Final-23. Inflammation of blood vessels leading to necrosis of the arms and legs in heavy smokers occurs most in which of the following conditions?
    a. Inherited lymphedema
    b. Thromboangiitis obliterans
    c. Systemic lupus erythematosus
    d. Cystic fibrosis
    e. Wegener granulomatosis
  84. 15-Final-24. Which of the following conditions presents in otherwise healthy individuals as a solitary, red, pedunculated swelling on the lower lip that has a tendency to bleed when gentle pressure is applied?
    a. Kaposi’s sarcoma
    b. Berry aneurysm
    c. Pyogenic granuloma
    d. Tuberculous granuloma
    e. Lymphedema
  85. 15-Final-25. The entire skin of a 3-month old infant appears bluish. Which of the following conditions is the most likely explanation?
    a. Bronchiolitis obliterans
    b. Peripheral emphysema
    c. Right-to-left shunt
    d. Left-to-right shunt
    e. Chronic obstructive pulmonary disease
  86. 15-Final-26. Spread of lymphoma to one or more extralymphatic organs or sites is designated as which of the following stages?
    a. I
    b. II
    c. III
    d. IV
    e. All of the above
    d
  87. xx15-Final-27. Which of the following diseases is most likely to present as multiple painful radiolucent lesions in bone in elderly people?
    a. Achondroplasia
    b. Letterer-Siwe disease
    c. Multiple myeloma
    d. Gardner syndrome
    e. Osteopetrosis
    c
  88. 15-Final-28. Which of the following is a neoplasm of altered B lymphocytes?
    a. Kaposi sarcoma
    b. Mesothelioma
    c. Langerhans cell histiocytosis
    d. Rhabdomyosarcoma
    e. Multiple myeloma
  89. 15-Final-29. Which of the following statements about Reed-Sternberg cells is/are correct?
    a. They characterize Hodgkin lymphoma
    b. They are binucleate
    c. They have large, owl-eyed nucleoli
    d. ` Nucleoli are generally surrounded by a clear halo
    e. All of the above
  90. 15-Final-30. Which of the following is/are findings in acute myeloid leukemia?
    a. Anemia
    b. Thrombocytopenia
    c. Neutropenia
    d. Pancytopenia
    e. All of the above
  91. 15-Final-31. Which of the following diseases affects approximately 8% to 10% of African-Americans in the United States?
    a. Sickle cell disease
    b. Sickle cell trait
    c. Hodgkin lymphoma
    d. Disseminated Langerhans cell histiocytosis
    e. Localized Langerhans cell histiocytosis
  92. 15-Final-32. Thrombocytopenic purpura occurs in the highest proportion of patients diagnosed with which of the following diseases?
    a. Psoriasis
    b. Pemphigus vulgaris
    c. Paget’s disease
    d. Osteochondromatosis
    e. Systemic lupus erythematosus
  93. 15-Final-33. Which of the following changes is primarily responsible for severe cases of bronchiolitis obliterans?
    a. Goblet cell metaplasia
    b. Loss of bronchiolar cartilage
    c. Clara cell hyperplasia
    d. Hyaline membranes
    e. Smooth muscle necrosis
  94. 15-Final-34. Which of the following tissue elements replaces pulmonary parenchyma after tissue damage caused by inflammatory mediators?
    a. Smooth muscle
    b. Cartilage
    c. Mucus
    d. Collagen
    e. Pseudostratified ciliated columnar epithelium with goblet cells
  95. 15-Final-35. Which of the following diseases is the consequence of an imbalance between proteolytic agents and their inhibitors?
    a. Bronchiolitis obliterans
    b. Idiopathic pulmonary fibrosis
    c. Cystic fibrosis
    d. Bronchiectasis
    e. Emphysema
  96. 15-Final-36. Intermittent and reversible airway obstruction is the hallmark of which of the following of the following diseases?
    a. Emphysema
    b. Acute lung injury
    c. Asthma
    d. Asbestosis
    e. All of the above
  97. 15-Final-37. Which of the following conditions is the consequence of exposure to asbestos?
    a. Emphysema
    b. Mesothelioma
    c. Atelectasis
    d. Bronchiectasis
    e. Nosocomial infection
  98. 15-Final-38. Multiple small necrotizing granulomas throughout the lungs, liver and other organs is most consistent with which of the following diseases?
    a. Sarcoidosis
    b. Tuberculosis
    c. Metastatic sarcoma
    d. Bacteremia
    e. All of the above
  99. 15-Final-39. Which of the following is the most common primary malignant tumor in the adult kidney?
    a. Squamous cell carcinoma
    b. Angiosarcoma
    c. Tubular adenocarcinoma
    d. Renal cell carcinoma
    e. Peritoneal sarcoma
  100. 15-Final-40. Azotemia refers to which of the following changes?
    a. Elevated blood urea nitrogen and creatinine
    b. Elevated serum calcium and inorganic phosphorus
    c. Hypoxemia
    d. Elevated bilirubin
    e. All of the above
  101. 15-Final-41. Clinical findings in patients experiencing nephrotic syndrome include which of the following?
    a. Severe proteinuria
    b. Hypoalbuminemia
    c. Generalized edema
    d. Hyperlipidemia
    e. All of the above
  102. 15-Final-42. Minimal change disease and IgA nephropathy primarily affect which part of the kidney?
    a. Proximal convoluted tubule
    b. Distal convoluted tubule
    c. Interstitium
    d. Renal corpuscle
    e. Renal pelvis
  103. 15-Final-43. Which of the following is an autosomal recessive disorder that is most likely to result in pulmonary or renal failure early in life?
    a. Childhood polycystic disease
    b. Adult polycystic disease
    c. Acute respiratory distress syndrome
    d. Rapidly progressive glomerulonephritis
    e. Pyelonephritis
  104. 15-Final-44. Epithelial cells exhibit “owl eye” nuclei in disease caused by which of the following viruses?
    a. HSV
    b. VZV
    c. CMV
    d. HPV
    e. All of the above
  105. 15-Final-45. Epithelium lining the lower esophagus is replaced by glandular epithelium of the stomach and by intestinal epithelium in which of the following conditions?
    a. Candidiasis
    b. Reflux esophagitis
    c. Myocardial infarction
    d. Cytomegalovirus infection
    e. H. pylori infection
  106. 15-Final-46. Which of the following is the most common consequence of alcohol and tobacco abuse, operating synergistically?
    a. Zollinger-Ellison syndrome
    b. Esophageal squamous cell carcinoma
    c. Barrett’s esophagus
    d. Diabetes mellitus
    e. Pernicious anemia
  107. 15-Final-47. Which of the following changes is most commonly seen in alcoholics?
    a. Bronchial adenomatous polyposis
    b. Longitudinal tears in the lower esophagus
    c. Esophageal intraepithelial eosinophilia
    d. Feline esophagus
    e. Hypertrophic pyloric stenosis
  108. 15-Final-48. Which of the following is the initial change that eventually leads to esophageal adenocarcinoma?
    a. Squamous cell carcinoma
    b. Boerhaave syndrome
    c. Mallory-Weiss syndrome
    d. Barrett’s esophagus
    e. Pernicious anemia
  109. 15-Final-49. Soft white plaques lining esophageal mucosa are most likely to be due to which of the following conditions?
    a. Herpes simplex virus
    b. Candidiasis
    c. Cytomegalovirus
    d. HAART
    e. Hematemesis
  110. 15-Final-50. Biopsy of the stomach reveals a curved gram-negative rod with flagella in mucus. Which of the following is the most likely diagnosis?
    a. Chronic gastritis
    b. Allergic gastritis
    c. Gastric stenosis
    d. Malabsorption syndrome
    e. Crohn’s disease
  111. 15-Final-51. Which of the following is the most significant risk factor for gastric adenocarcinoma?
    a. C. albicans
    b. Cytomegalovirus
    c. H. pylori
    d. Cirrhosis
    e. Volvulus
  112. 15-Final-52. Gross examination of the stomach lining reveals an irregular mass with a central ulceration that has elevated, “heaped-up” margins. Which of the following is the most likely diagnosis?
    a. Squamous cell carcinoma
    b. Chronic sclerosing gastritis
    c. Adenocarcinoma
    d. Fibrosarcoma
    e. Gastric infarct
  113. 15-Final-53. In which of the following diseases are multiple small oral mucosal abscesses (pyostomatitis vegetans) most likely to occur?
    a. Diverticulosis
    b. Ulcerative colitis
    c. Tropical sprue
    d. Viral gastroenteritis
    e. Gardner syndrome
  114. 15-Final-54. Which of the following diseases is the most likely to be fatal due to massive watery diarrhea and dehydration?
    a. Viral gastroenteritis
    b. Appendicitis
    c. Celiac disease
    d. Cholera
    e. Crohn’s disease
  115. 15-Final-55. If untreated, what percentage of people with diagnosed familial adenomatous syndrome will eventually develop cancer?
    a. 5
    b. 20
    c. 35
    d. 50
    e. 90
  116. 15-Final-56. Which of the following are the most common lesions in the small intestine in patients diagnosed with Peutz-Jeghers syndrome?
    a. Hamartomas
    b. Freckles
    c. Villous adenomas
    d. Tubular adenomas
    e. Adenocarcinomas
  117. 15-Final-57. Which of the following diseases is the most likely to result in diabetes mellitus?
    a. Pernicious anemia
    b. Peutz-Jeghers syndrome
    c. Chronic pancreatitis
    d. Reye’s syndrome
    e. Reflux esophagitis
  118. 15-Final-58. Which of the following microscopic changes is most consistent with intestinal malabsorption?
    a. Absence of mucosa associated lymphoid tissue
    b. Colonic pouches
    c. Enlarged and dysplastic epithelium lining crypts of Lieberkuhn
    d. Short villi
    e. Rectal abscesses
  119. 15-Final-59. Hypersensitivity to which the following agents is associated with intestinal malabsorption?
    a. Amyloid
    b. C. albicans
    c. Gluten
    d. C. difficile
    e. All of the above
  120. 15-Final-60. Which of the following conditions is most likely to result in shock due to systemic collapse?
    a. Acute pancreatitis
    b. Diverticulosis
    c. Ileus
    d. Colonic epithelial metaplasia
    e. Splenic atrophy
  121. 15-Final-61. At which of the following sites is it most common to find nodules of regenerating parenchymal cells surrounded by dense, irregular, collagen fibers, resulting in disturbance of vascular flow?
    a. Spleen
    b. Stomach
    c. Colon
    d. Liver
    e. Pituitary gland
  122. 15-Final-62. Which of the following changes occur in acute viral hepatitis?
    a. Apoptosis of hepatocytes
    b. Infiltrate of mononuclear inflammatory cells
    c. Elevated alkaline phosphatase and aminotransferases
    d. Ballooning degeneration of hepatocytes
    e All of the above
    e
  123. 15-Final-63. Which of the following is most firmly established as an inherited cause of cirrhosis?
    a. Alpha-1-antitrypsin deficiency
    b. Chronic Hepatitis B virus
    c. Chronic Hepatitis C Virus
    d. Chronic alcoholism
    e. Acute hepatitis
    a
  124. 15-Final-64. Jaundice occurs most often in which of the following conditions?
    a. Pyelonephritis
    b. Pernicious anemia
    c. Chronic obstructive pulmonary disease
    d. Cirrhosis
    e. Diverticulitis
    b
  125. 15-Final-65. Which of the following is the most common cause of chronic hepatitis?
    a. MERSA
    b. Hepatitis C virus infection
    c. Wilson’s disease
    d. Alpha-1-antitrypsin deficiency
    e. Acute post-streptococcal infection
    b
  126. 15-Final-66. Which of the following is the most common consequence of acute hepatitis?
    a. Resolution
    b. Cirrhosis
    c. Death
    d. Hepatocellular carcinoma
    e Coma
    a
  127. 15-Final-67. What percentage of uterine leiomyomas (“fibroids”) become malignant?
    a. Less than 1%
    b. 20%
    c. 50%
    d. 80%
    e. 1000%
    a
  128. 15-Final-68. Mutations in which of the following genes is most strongly linked to breast cancer?
    a. MART
    b. BAGE
    c. gp100
    d. EBNA
    e. BRCA-1
    e
  129. xx15-Final-69. Which of the following conditions is the most likely to contain or develop into cancer?
    a. Intradermal melanocytic nevus
    b. Junctional melanocytic nevus
    c. Psoriasis
    d. Atypical endometrial hyperplasia
    e. Seborrheic dermatitis
    d
  130. 15-Final-70. Which of the following lesions is most likely to contain teeth?
    a. Leiomyoma
    b. Ovarian dermoid cyst
    c. Nodular basal cell carcinoma
    d. Testicular adenoma
    e. Craniopharyngioma
    b
  131. 15-Final-71. Which of the following lesions presents as warty mucosal enlargements composed of proliferating stratified squamous epithelium with viral cytopathy?
    a. Kaposi sarcoma
    b. Condyloma acuminatum
    c. Leiomyoma
    d. Prostate carcinoma
    e. Mesothelioma
    b
  132. 15-Final-72. The presence or absence of myoepithelial cells is employed as a criterion in the diagnosis of tumors in which of the following organs?
    a. Stomach
    b. Female breast
    c. Colon
    d. Liver
    e. All of the above
    b

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Author:
neopho
ID:
325913
Filename:
Systemic Pathology 2015 Archives - 3 final
Updated:
2016-11-21 14:45:01
Tags:
SystemicPathology
Folders:
SystemicPathology
Description:
Systemic Pathology Archives 2015 Last midterm Final
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