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  1. Describe adhesion > aggregation > plt plug semi-detailed
    • Adhesion: GP1B binds collagen (req. vWF) --release-->ADP, FV, fibrinogen, more
    • Aggregation: ADP stims shape change, exposes GPIIb/IIIa --> GPIIb/IIIa binds fibrinogen
    • Plt plug formation, limited to site by inhibitors
  2. Draw the factor pathways for PT/PTT
    • PTT:  Collagen,MWK -> XII -> XI - IX -VIII-> X
    • PT: TF (PF3) -> VII -> X
    • Common: X -5-> 2 -> 1 <-XIII <- 2
    • Refer to notes
    • *note - XIIIa is what provides D-Dimers by crosslinking fibrin
  3. Factors that are enzymes?  Cofactors?
    • Enzymes: II,VII,IX,X,XI,XII,XII
    • Cofactors: III,V,VIII,HMWK
  4. Contact, prothrombin, fibrinogen (groups) - factors, vit k dependent, consumed in clot?
    • Contact: XI,XII,PK,HMWK / N / N
    • Prothrombin: II,VII,IX,X / Y / only II
    • Fibrinogen: I,V,VIII,XIII / N / Y
  5. PT and PTT: ref range, pathways tested, drugs tested, reagents
    • PT: <13s / extrinsic + common +vit K def / warfarin, coumadin / Tissue thromboplastin + CaCl2
    • There's a single T because if it's EX.
    • PTT: 20-40s / intrinsic, common / heparin / activator + phospholipid + CaCl2
  6. Alt names of Factor II, Factor I?  Their interaction?
    • II = prothrombin
    • IIa = thrombin which acts on I (and XIII)
    • I = fibrinogen
    • Ia = fibrin
  7. Describe FV Leiden
    • Normally Proteins C, S inactivate FV and FVIII
    • FV Leiden is a conf change which resist ACP and therfore increases thrombosis
  8. How does fibrinolysis occur?
    • activators convert plasminogen -> plasmin
    • plasmin cleaves fibrin strands producing FDPs, DDimers
  9. INR calc
    INR = (PT/local mean)^ISI
  10. Describe the thrombin time assay
    • Excess thrombin to plasma, measure of fibrinogen
    • Increased time - decreased fibrinogen, dysfunctional fibrinogen, heparin, etc
  11. Describe D-Dimer's use
    • NEGATIVE predictive value only (DVT, DIC, etc)
    • Immunoassay
  12. QUCIK REVIEW OF "SPECIAL TESTS" AREA NOTES
  13. Russel's viper is for? Reptilase?
    • Russel's viper: lupus anticoagulant
    • Reptilase: thrombin time (meas of fibrinogen) but unaffected by heparin
  14. briefly describe hemophilia A, B, C, vWD, Lupus anticoagulant, factor VIII inhib, Vit k def
    • A: decreased VIII, sex-linked recessive, same symp as B
    • B: decreased IX, sex-linked recessive, same symp as B
    • C: decreased XI, inconsistant severity, increased in jews
    • vWD: vWD defect resulting in decreased VIII, autosomal dominant, treat with DDAVP or cryo
    • LA: IgG anti-phospholipid, prolonged PTT
    • FVIII I: IgG anti-FVIII, prolonged PTT and mixing study
    • Vit k def: decreased function II,VII,IX,X

Card Set Information

Author:
victimsofadown
ID:
329025
Filename:
Coag
Updated:
2017-03-01 04:50:55
Tags:
Coag
Folders:
ASCP
Description:
Coag
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