Drugs note cards.txt

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Drugs note cards.txt
2010-09-06 12:57:26
hb1 exam1 drugs

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  1. Ibuprofen (NSAID)
    inhibits COX-1 and COX-2 and therefore prostaglandin synthesis? only S-isomer is biologically active
  2. Cisplatin
    DNA crosslinking agent, chemotherapeutic agents
  3. Etoposide
    topoisomerase inhibitor, induces ds DNA breaks
  4. Methotrexate
    Anti-metabolite that inhibits enzymes involved in nucleoside production
  5. AZT
    targets activity of DNA pols (inhibits elongation), AZT commonly used in HIV therapy
  6. Cytoxan
    Alkylating agents
  7. Rifampin
    binds prok RNA pol, for TB
  8. Actinomycin D/Dactinomycin D
    binds DNA template and interferes is RNA pol progression (also used in tumor therapy), antibiotic
  9. 5-aza-2�-deoxycytidine (decitabine)
    (Rett treatment)nucleoside analog that inhibits DNMTs by trapping them in a covalent complex on DNA by preventing the beta-elimination step of catalysis�resulting in the enzymes� degradation�to be active, must be incorporated into genome of cell�also toxin to bone marrow
  10. Tetracycline
    bacterial ribosome A site
  11. Streptomycin
    Bacterial 30S sub-unit (blocks initiation)
  12. Erythromycin
    Bacterial 50S subunit (blocks translocation)
  13. Chloramphenicol
    bacterial peptidyl transferase
  14. Puromycin
    Premature termination
  15. Cyclohexamide
    Euk 80S ribosome
  16. Aspirin-(ASA)
    Irreversibly acetylates and inactivates COX-1 at serine residue
  17. Tysabri (natalizumab)
    Monoclonal antibody designed to block integrin function and prevent leukocytes from crossing the blood brain barrier
  18. Ceredase and Cerenzyme
    expensive enzyme replacement therapy for Gaucher�s
  19. Etanercept
    a fusion protein for treatment of RA, fuse to IgG1 to allow for secretion-perturbs TNFalpha pathway, involved in inflammation
  20. D-tubocurarine
    a nonpolarizing blocker of Ach
  21. Taxol (Paclitaxel)
    for treatment of lung, ovarian, breast, head and neck cancer. Hyperstabilizes MT by binding to B-tubulin and preventing dynamic instability
  22. Vinca alkaloids (vinblastine and vincristine)
    used in treatment of leukemia and lymphoma, binds to tubulin dimers to inhibit their assembly
  23. Colchicine
    used for treatment of gout, studied for anti-cancer drug, however extremely toxin. High affinity for tubulin and prevents polymerization
  24. Mebendazole (MT drug)
  25. Griseofulvin Antifungal
    (binds to fungal MTs)
  26. Farnesyl transferase inhibitors (ftis)
    originally studied for cancer, but now used as treatment for Progeria (premature aging caused by defect in nuclear lamin, type 5 intermediate filament, causes nuclear wrinkling)
  27. Imatinib/Gleevec
    inhibits ATP binding and therefore cascade inhibited and you don�t get BCR-ABL protein, not as specific, will work against GIST (c-KIT tyrosine kinase receptor)�can develop resistance (possibly because of P loop mutation)
  28. Nilotinib(Tasigna)
    more specific than Imatnib and well tolerated by patients, now treatment for Ph+ CML or if pt is resistant to Imatinib
  29. Trastuzamab (Herceptin)
    used for pts with advanced breast cancer. Targets HER2 extracellular domain. Can work by blocking dimerization, or targeting the immune system to inhibit/kill overexpressing HER2 cells, or by allosterically blocking the ligand binding site
  30. Lapatinib
    binds to intracellular domain of HER2, helps with inflammatory breast cancer