Intro to brain and behavior part 2
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What is senile dementia?
Progressive degration of cognitive faculties.
What is mild cognitive impairment (MCI)?
Mild senile dementia
What are the possible causes of Alzheimer's disease?
- Down syndrome (genetic link)
- Genetic markers (genetic link; specific genes)
- Parkinson's disease
- Serious infection from AIDS or Syphilis
- Brain tumors
- Various vitamin deficiencies
- Various metabolic disorders
How many people in the last 25 years have had Alzheimer's?
Out of the 4-5 million people who have had Alzheimer's in the last 25 years, what portion where over 65 years old?
What is the percentage risk of developing Alzheimer's between the ages 60-70?
What is the percentage risk of developing Alzheimer's between the ages 70-80?
What is the percentage risk of developing Alzheimer's between the ages 80-90?
What are the behavioral symptoms of Alzheimer's disease?
- Memory deficits (explicit long term)
- Decreased appetite
- Psychosis (distortion of reality)
What are some examples of atrophy in the brain for an individual with Alzheimer's?
- Decreased volume of overall cortex
- Decreased volume of hippocampus
- Decreased acetylcholine
- Formation of plaques
- Formation of tangles
What is acetylcholine?
A neurotransmitter that is responsible for alertness, helps process memory, and monitors conscious state.
What are plaques?
An over accumulation of amyloids (proteins) that can get into the synapse.
What are tangles?
Microtubules that are messed up by the over accumulation of the tau protein; this can cause the cell to malfunction.
What is the treatment of Alzheimer's?
No cure at the moment because there has not been effective treatment.
What are some current attempts for the treatment of Alzheimer's?
- Boosting acetylcholine levels
What is curcumin?
A natural substance that assists with decreasing amyloid and tau damage.
What are some possibilities in treatments for Alzheimer's?
- Substance to bind to amyloid (render it not effective)
- Decrease amyloid production
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