The flashcards below were created by user
duncamunk
on FreezingBlue Flashcards.
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Rifampicin
Rifamycin
- Inhibits initiation of RNA synthesis
- Blocks formation of first phosphodiester bond
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Actinomycin D
- Inhibits RNA synthesis by incalating DNA
- Causes mutations
- Works in both pro- and eukaryotes
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Alpha-amanitin
- Inihibits eukaryotic RNA polymerase
- RNA pol I - (nucleolus) insensitive
- RNA pol II - (mRNA) highly sensitive
- RNA pol III - (tRNA) moderately sensitive
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Antibiotics to bacteria
- Inhibit protein translation
- Act of rRNA, not the ribosomal protein
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Diphtheria toxin
Inihibits translocation of protein being synthesized
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Puromycin
- Causes premature chain termination
- Acts like aminoacyl-tRNA
- Affects both pro- and eukaryotes
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Streptomycin
Inhibits initiation and causes misreading of mRNA in prokaryotes
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