Biochem Drugs/Proteins

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Rifampicin
Rifamycin
- Inhibits initiation of RNA synthesis
- Blocks formation of first phosphodiester bond
Actinomycin D
- Inhibits RNA synthesis by incalating DNA
- Causes mutations
- Works in both pro- and eukaryotes
Alpha-amanitin
- Inihibits eukaryotic RNA polymerase
- RNA pol I - (nucleolus) insensitive
- RNA pol II - (mRNA) highly sensitive
- RNA pol III - (tRNA) moderately sensitive
Antibiotics to bacteria
- Inhibit protein translation
- Act of rRNA, not the ribosomal protein
Diphtheria toxin

Inihibits translocation of protein being synthesized
Puromycin
- Causes premature chain termination
- Acts like aminoacyl-tRNA
- Affects both pro- and eukaryotes
Streptomycin

Inhibits initiation and causes misreading of mRNA in prokaryotes

Author

33228

Card Set

Biochem Drugs/Proteins

Description

Drugs and developmental proteins covered on Test 1

Updated

2010-09-07T19:36:59Z

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