Usmle 1 Inflammation

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  1. SHUTTING DOWN THE Na-K ATPase
    • Potassium still leaks out

    • Cell becomes more negative > less likely to depolarize

    • With Na trapped within the cell, calcium also gets trapped within the cel

    •    – This increases contractility
    •       – DIGITALIS
    •       – DIGITOXIN
    •       – OUBAIN
  2. EKG CHANGES
    • Na-K ATPase shuts down when a vessel is 70% stenosed

    • Potassium leaks out, making cells more negative

    • • This is why you get ST-wave DEPRESSION
    • Image Upload
  3. ST-WAVE DEPRESSION
    • Early ischemia

    • 70% stenosis

    • SYMPTOMS BEGIN

    • Subendocardial ischemia

    • STABLE ANGINA

    •    – Comes on with exertion; goes away with rest
    •    – 30% flow is enough at rest, but not on exertion
    •    – TX: VASODILATORS > increase radius increases flow

Card Set Information

Author:
docbrito
ID:
332725
Filename:
Usmle 1 Inflammation
Updated:
2017-07-05 18:56:19
Tags:
Inflammation
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Description:
Inflammation
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