Cell injury

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  1. Causes of hypoxemia
    • Respiratory Acidosis
    • Ventilation Defects(RDS,ARDS)
    • Perfusion defect(Pulmonary Embolus)
    • Diffusion defect(Sarcoidosis, Pulmonary edema)
  2. Treatment for Methemoglobinemia
    • Methylene blue
    • Vitamin C
  3. Treatment for CO
    100% Oxygen
  4. Things that block Cytocho=rome Oxidase(Tranfer electron to Oxygen)
    • CO
    • Cyanide
  5. Right Shift Curves
    • Fever
    • Low pH
    • 2,3 BPG
    • High Altitude
  6. Left Shift Curves
    • CO
    • Methemoglobinemia
    • HbF
    • Dec. in 2,3 BPG
    • Alkalosis
  7. Uncoupling agent (Ability of Inner Mitochondria to synthesize ATP)
    • Dinitrylphenol
    • Alcohol
    • Salicylate
  8. Complication of Salicylate:
    Hyperthermia
  9. Free Radical (Unpaired Electron that is very unstable and damage tissue)
    • Oxygen (ROP, BPD)
    • Hydroxy free radical (Iron Overload)
    • Acetaminophen
    • Cabon tetrachloride
    • Aspirin + Tylenol
  10. Apoptosis
    • Embryo: Gut Lumen
    • King of Guy Body: Y chromosome release MIF
    • Female: X Chromosome
    • Thymus in Anterior Mediastinum
    • Apoptosis Major cancer killing mechanism
  11. Coagulative Necrosis
    Sudden cut off of blood supply to organ
  12. Pale Infarct
    Good Consistency: Heart, Kidney, Spleen and Liver
  13. Hemorrhagic Infarct
    Loose Consistency: Lung, Bowel, Testis
  14. MC cause of Bowel Infarction
    Adhesion from previous surgeries
  15. Staphylococcus
    • Gm Positive cocci in cluster
    • Coagulase converts fibrinogen into fibrin which localizes infection (Pus)
  16. Streptococcus
    Streptococcus release hyalurinidase which break down GAG in tissue and infection spread through tissue (Cellulitis)
  17. Fibrinoid Necrosis
    • d/t necrosis of immunological damage
    • HSP
    • Rh. fever
    • Rh. Arthritis
    • Glomerulonephritis
  18. Why protrubent abdomen in Kwashiorker
    • Lack of protein (Apoprotein) to put around VLDL and export it out of liver
    • Decrease in protein intake which decreases oncotic pressure and ascites
  19. Dystrophic Calcification
    • Damaged tissue gets calcified
    • Enzymatic fat necrosis
    • Hematoma in foot
    • Aortic Stenosis
  20. Metastatic Calcification
    Incase of hypercalcemia and hyperphosphatemia, calcium gets deposited in normal tissue
  21. Phases of Cell Cycle
    • G1 phase
    • S Phase
    • G2 phase
    • M Phase
  22. G1-S restriction Point
    • Rb suppressor gene
    • p53 suppressor gene
  23. Rb suppressor gene mutation
    • Retinoblastoma
    • Osteogenic Sarcoma
    • Breast Cancer
  24. M Phase Inhibitors
    • Paclitaxel
    • Vinblastine
    • Vincristine
  25. S Phase inhibitors
    Antimetabolites: Azathioprine, Cladribine, Cytarabine, 5-FU, Hydroxyurea, Methotrexate, 6-MP
  26. G2 phase inhibitors
    Bleomycin
  27. Drugs Actinng in both S phase and G2 phase
    Topoisomerase Inhibitor (Etoposide, Teniposide, Irinotectan, Topotectan)
  28. Cell Cycle Independent Drugs
    • Platinum agents: Cisplatin
    • Alkylating Agents: Busulfan, Cyclophosphomide, Ifosfamide, Nitrosoureas(carmustine)
  29. Chemotactic Agent
    C5a, LT B4, IL-8
  30. Osponizer
    IgG, C3b

Card Set Information

Author:
drsubashb
ID:
333856
Filename:
Cell injury
Updated:
2017-09-07 14:05:11
Tags:
Cell
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Description:
Cel Injury
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