membrane transport mechanisms

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  1. Main points to keep in mind about the difference in fluid outside or in the cell 4
    • **K+ on outside is less than 5mM but in the cell its more than 100mM
    • 1. outside is rich in Na and Cl but low in K+ vice versa inside cell
    • 2. massive difference in Ca levels between in and out
    • 3.more protein outside of cell
    • 4. in cell is more acidic than outside
  2. in cell conc and out conc
    K
    Na
    Ca
    Cl
    • I: K-120mM, Na-15,Ca-.001, Cl-20
    • O: K-4.5, Na-145, Ca-1.2, Cl-102
  3. permeant solute
    permeable to solute
    • solute can pass through the layer
    • the layer is allowing things to pass through
  4. Image Upload
    fick equation determined the movement (flux) or diffusion of a solute across a barrier of a given surface area

    • J is determined by:
    • permeability of the solute across the barrier
    • concentration gradient between 2 compartments separated by barrier (diff in concentration of solute in compartment)
    • **C1-C2=0 movement is 0
    • **if uncharged, solute determinant of the rate of movement is conc gradient
    • **if charged the electro chem gradient is determined by diff in conc as well as electrical potential diff across mem

    • permeability coefficient is determined by these 3:
    • area for diffusion; the greater area higher net diffusion of solute (no individual molecule)
    • solubility of the solute in the lipid phase of membrane
    • thickness of the barrier (thin = better)

Card Set Information

Author:
kaitiek09
ID:
334012
Filename:
membrane transport mechanisms
Updated:
2017-09-07 00:16:01
Tags:
medical
Folders:
FUNDAMENTALS OF MEDICINE
Description:
RUSM membrane transport mechanisms WEEK 1 FUNDAMENTALS 1
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