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TT
Thrombin Time
Measures the ability of thrombin to convert fibrinogen to fibrin and is useful in the evaluation of circulating antioagulants (pathologic inhibitors)
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TT is prolonged in what siutations
- Hypo & Dys fibrinogenemia
- Patients on heparin therapy
- Circulating FDP's
- Pathologic circulating inhibitors
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Mixing Studies
Patient plasma is mixed with normal plasma in varying concentrations, then incubated for 2 hours.
Corrected = Deficiency
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Reptilase Time
- Similar to TT, except it uses reptilase instead of thrombin.
- Not affected by heparin
Prolonged with: A & Dys fibrinogenemia
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Russell's Viper Venom
Test is based on the premise that LA/aPL activity is enhanced in the presence of reduced phospholipids. The reagent contains dilute RVV, CaCl, & phospholipids. The reagent is added to PPP. RVV activates FX resulting in a clot formation.
If Las/aPLs are present, the patients dRVVT is longer than that of the normal control
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