The flashcards below were created by user
on FreezingBlue Flashcards.
Measures the ability of thrombin to convert fibrinogen to fibrin and is useful in the evaluation of circulating antioagulants (pathologic inhibitors)
TT is prolonged in what siutations
- Hypo & Dys fibrinogenemia
- Patients on heparin therapy
- Circulating FDP's
- Pathologic circulating inhibitors
Patient plasma is mixed with normal plasma in varying concentrations, then incubated for 2 hours.
Corrected = Deficiency
- Similar to TT, except it uses reptilase instead of thrombin.
- Not affected by heparin
Prolonged with: A & Dys fibrinogenemia
Russell's Viper Venom
Test is based on the premise that LA/aPL activity is enhanced in the presence of reduced phospholipids. The reagent contains dilute RVV, CaCl, & phospholipids. The reagent is added to PPP. RVV activates FX resulting in a clot formation.
If Las/aPLs are present, the patients dRVVT is longer than that of the normal control