ATP hydrolysis

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  1. Why is ATP hydrolysis energetically favorable
    • drives synthesis of metabolites
    • phosphorylated compounds are more reactive
  2. difference between ΔG’o ang Gp
    • ΔG’o-biochemical standard free energy
    • ΔGp- actual free energy change for ATP hydrolysis
  3. 4 types of phosphoryl transfer reactio s
    • Phosphatases-H2O is an acceptor/nucleophile
    • phosphodiesterases- H2O is an acceptor/nuc
    • phosphorylases-phosphate is a nucleophile
    • kinases-nucelophile is not water
  4. Example of phosphatases
    • phosphatases: glucose phosphatases
    • enzyme grabs phosphate and adds an alcohol
  5. Phosphorylases
    • Polynucleotide Phosphorylase
    • oxygen of phosphorus attacks phosphoryl group of RNA chain
    • PNpase
  6. Example of Phosphodiesterases
    • RNAase A:alcohol from carbon 2 of glucose attacks phosphate and forms cyclic phosphate
    • water removes c-o bond from 2nd carbon on glucose
  7. Example of kinase
    pyruvate kinase: pyruvate grab phosphorus and it forms PEP
  8. why is the hydrolysis of PEP energetically favorable?
    pyruvate can form an enol form
  9. why is the hydrolysis of phosphocreatine energetically favorable?
    can be used to create ATP anaerobically
  10. Nerst equation
    E=E0 + (RT/nF) ln (acceptor/donor)
  11. pellagra
    niacin deficiency=levels of reduced NADHall dehydrogenases affectedenergy supply reducedNiacin was first isolated at U
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ATP hydrolysis
2017-11-16 22:11:56

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