SGU physio autonomic NS

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mlamaste
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33638
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SGU physio autonomic NS
Updated:
2010-09-09 10:39:13
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SGU physio autonomic NS
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SGU physio autonomic NS
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  1. ANS regulates?
    internal organs and adapts them to the need of the moment
  2. Internal Milieu?
    • chemical parameters (pH,O2,CO2)
    • Physical parameters (blood pressure, temperature)
  3. How are the ANS and the SNS separated?
    • In the PNS they are almost entirely separated
    • In the CNS they are intimately connected
  4. Divisions of the autonomic nervous system
    • Sympathetic division "Fight or Flight"
    • Parasympathetic division "Regeneration"
  5. Sympatheticus ______ and the Parasympatheticus _______
    speeds up, slows down
  6. Constricts Pupils
    Para
  7. dilates pupils
    sym
  8. stimulates salivation
    para
  9. inhibits salivation
    sym
  10. slows heartbeat
    para
  11. increases heart activity
    sym
  12. constricts airways
    para
  13. constricts blood vessels
    sym
  14. stimulates digestion
    para
  15. contracts smooth muscle
    sym
  16. contracts ureter
    para
  17. liver:stimulates glucose production and release
    sym
  18. pancreas,gall bladder: stimulates release of bile
    sym
  19. Distal large intestine:increase tonus, relaxes sphincter
    para
  20. stimulates sweat glands
    sym
  21. contracts urinary bladder, relaxes sphincter
    para
  22. stimulates penile errection
    para
  23. stimulates sweat glands
    sym
  24. adrenal medulla:secretion of epinephrine and norepinephrine
    sym
  25. relaxes urinary bladder
    sym
  26. stimulates ejaculation
    sym
  27. Primary parasympathetic neurotransmitters for preganglionic receptors and postganglionic receptors
    acethylcholine for both preganglionic and postganglionic receptors
  28. What is the preganglionic parasympathetic receptor called?
    cholinergic
  29. what is the postganglionic neuron receptor called?
    cholinergic
  30. nicotine mimics what neurotransmitter?
    acetylcholine
  31. muscarine mimics what neurotransmitter?
    acetylcholine
  32. Where are muscarine receptors located?
    all postganglionic parasympathetic neurons and cholinergic sympathetic neurons
  33. Where are nicotine receptors located?
    • all preganglionic: sympathetic and parasympathetic neurons
    • motor endplates synapses of skeletal muscle
  34. Parasympathomimetic agents and therapy
    • Nicotene: therapies;emectica, stomach wash-out, artificial respiration, cardiovascular agents, muscle relaxant agents
    • Muscarine: therapies; atropine
  35. Parasympatholytic agents
    • Atropine
    • Curarine
  36. Atropine action,
    blocks muscarinic receptors, extremely high doses block nicotinic receptors
  37. Atropine pharmacologic effects
    tachycardia, relaxation of GI tract, dilation of bronchioles, madras's, anhydrotic effect on glands
  38. Atropine clinical uses
    preanaestic medication: prevents bradycardia
  39. Atropine toxicity
    interspecies variation:herbivores are generally more resistant than carnivores
  40. Curarine agents action
    prevents the depolarization of postsynaptic membrane of the motor end plate MUSCLE PARALYSIS
  41. Why can you meat poisoned by Curare
    poor resorption of curarine
  42. Curarine
    clinical use derivates of curarine used as peripheral muscle relaxant in intravenous anesthesia
  43. What kind of receptors do the preganglionic neuron have? postganglionic?
    cholinergic, adrenergic (some cholinergic)
  44. Adrenergic receptors bind
    norepinephrine and epinephrine
  45. Adrenergic receptor classifications
    alpha and beta
  46. How many kinds of alpha receptors?Beta receptors?
    2 alpha, 3 beta
  47. Norepinephrine binds better to ______?
    alpha receptors
  48. Epinephrine binds better to ________
    Beta receptors
  49. Sympathomimetic agents
    • epinephrine
    • amphetamine
  50. Epinephrine clinical significance
    • adjuvents to local anaesthetics
    • (constriction of bloodvessels which in turn extends the duration of local anaesthesia)
  51. Amphetamine action
    • pronounced stimulation of the CNS (alertness, euphoria, loss of fatigue)
    • peripheral alpha and beta effects (similar to norepinephrine)
    • effects diminish after repeated application
    • abuse as doping agent(habit formation)
  52. Sympatholytic agents
    • alpha blockers
    • beta blockers
  53. alpha blocker clinical use
    treatment of peripheral vasospasm
  54. beta blocker types
    • selective B1, B2, or B3
    • non-selective B1,B2, and B3
  55. Beta 1 blocker (atenolol)
    Heart: prophylaxis and agina pectoris, arrhythmias

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