MSK EXTRACELLULAR MATRIX RVU

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Trinabarr
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33784
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MSK EXTRACELLULAR MATRIX RVU
Updated:
2010-09-10 00:12:10
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RVU MSK EXTRACELLULAR MATRIX OSM
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MSK Extracellular Matrix-RVU 2010
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  1. Name and describe the constituents of ECM
    • fibers
    • collagen fibers add tensile strength elastic fibers add elasticity reticular fibers “rigid” framework

    • ground substance
    • withstand compression glycosaminoglycans (GAGs) proteoglycans adhesive glycoproteins

    tissue fluid maintains hydration
  2. Describe Collagen Fibers
    many different types (≈29)

    most fibrillar, some amorphous (non-fibrillar)

    • type I most common -
    • * tough, inelastic fiber add tensile strength to CT
    • *»20% of total body protein
    • * stronger than steel

    * reticular fibers actually type III collagen add strength to stromal elements
  3. What is the molecular formula, native polymer, and tissue distribution for Type 1 Collagen?
    note a = alpha

    [a1(l)]2a2

    • fibril
    • (67 nm)

    • skin, tendon, bone, dentin, fascia
    • (high tensile strength- 90% of total body collagen)
  4. What is the molecular formula, native polymer, and tissue distribution for Type 2 Collagen
    [a1(II)]3

    • fibril
    • (67 nm)

    cartilage, nucleus pulposus, notochord, vitreous body, cornea
  5. What is the molecular formula, native polymer, and tissue distribution for Type 3 Collagen
    [a1(Ill)]3

    • fibril
    • (67 nm)

    • skin, uterus, blood vessels,
    • reticular fibers, spleen, lymph nodes
  6. What is the molecular formula, native polymer, and tissue distribution for Type 4Collagen
    [a1(IV)]3

    • non-fibrillar
    • (globular)

    basal lamina of epithelial cells, kidney glomeruli, lens capsule, etc.
  7. What is the molecular formula, native polymer, and tissue distribution for Type 5Collagen
    [a1(VII)]3

    small fibers(67 nm)

    anchoring fibrils in basal laminae
  8. Describe formation and composition of Type 1
    formed by packing of tropocollagen molecules into collagen fibrils


    triple helix structurecomposed of:

    a1 procollagen - 2 chains

    a2 procollagen - 1 chain
  9. List events in collagen type 1 intracellular production
    • 1. transcription of message in nucleus
    • 2. translation of message (on RER)
    • 3. synthesis of preprocollagen w registration peptides
    • 4. cleavage of signal proteins (in RER)
    • 5. hydroxylation of proline and lysine(in RER)
    • 6. glycosylation of hydroxylated lysines (in RER)
    • 7. formation of procollagen into secretory vesicles
    • 8. movement into transfer vesicle
    • 9. packaging of procollagen into secretory vessicles
    • 10. transport to plasma membrane (cytoskeletal elements)
    • 11. exocytosis of helical procollagen
  10. List sequence of extracellular events in collagen synthesis
    • 11. exocytosis of helical procollagen (depends on text)
    • 12. Cleavage of non-helical registration proteins to form tropocollagen.
    • 13. polymerization of tropocollagen into collagen fibrils

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