antibiotics

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avangord
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34138
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antibiotics
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2010-09-12 18:37:02
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antibiotics
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antibiotics
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  1. Natural Penicillins
    Pen G
    Pen V
    • Gram + aerobes: yes
    • Gram - aerobes: only neisseria
    • anaerobes: yes
  2. Penicillinase resistant penicillins
    cloxacillin
    dicloxacillin
    nafcillin
    oxacillin
    • Gram + aerobes only
    • no enterococcus
    • mixed renal/hepatic metabolism
    • nafcillin hepatic
  3. Amino penicillins
    amoxicillin
    ampicillin
    • Gram + aerobes: yes
    • Gram - aerobes: yes, no pseudomonas
    • anaerobes: yes
    • mostly renal elim.
  4. Carboxy penicillins
    ticarcillin
    • Gram + aerobes: yes, no staph
    • Gram - aerobes: yes
    • Anaerobes: yes
    • mixed renal and hepatic elim
  5. Ureido penicillins
    piperacillin
    mezlocillin
    • Gram + aerobes: yes, no staph
    • Gram - aerobes: yes
    • Anaerobes: yes
    • mixed renal/hepatic elim
  6. 1st gen cephalosporins
    Cephalexin po
    Cefazolin IV
    cephalothin IV
    • Gram + aerobes: +++, no enterococcus
    • Gram - aerobes: +, enteric
    • little CNS
    • renal elim
  7. 2nd gen cephalosporins
    cefaclor po
    cefuroxime IV
    cefoxitin IV
    • Gram + aerobes: ++ no enterococcus
    • Gram - aerobes: ++ enteric, haemophilus, moraxella
    • CNS
    • renal elimination
  8. cephamycins
    2nd gen
    cefoxitin, cefotetan, cefmetazole
    • Gram + aerobes: ++ no enterococcus
    • Gram - aerobes: ++
    • anaerobes: ++
    • CNS
    • renal elim
  9. 3rd gen cephalosporins
    cefdinir po
    ceftriaxone IV
    ceftazidime IV
    • Gram + aerobes: + no enterococcus
    • Gram - aerobes: +++
    • CNS
    • renal elim
    • ceftriaxone elim in bile (QD)
    • ceftazidime: pseudomonas
  10. 4th gen cephalosporin
    cefepime IV
    • Gram + aerobes: ++
    • Gram - aerobes: +++ and pseudomonas
    • CNS
    • renal elim
  11. Carbapenems
    imipenem w/cilastin
    meropenem
    ertapenem
    doripenem
    • Gram + aerobes: yes
    • Gram - aerobes: yes
    • pseudomonas: all but ertapenem
    • anaerobes: yes
    • CNS
    • renal elim
  12. Monobactam
    aztreonam IV
    • Gram - aerobes only
    • some CNS
    • renal elim
  13. Macrolides
    erythromycin
    azithromycin
    clarithromycin
    • Gram + aerobes: yes
    • Gram - aerobes: moderate
    • Atypicals: yes
    • Other: h.pylori
    • hepatic metab
  14. Ketolide
    telithromycin
    • Gram + aerobes: yes
    • Gram - aerobes: moderate
    • Atypicals: yes
    • Other: h.pylori
    • hepatic/renal metab
    • 3A4 inhibitor
  15. Clindamycin
    • Gram + aerobes: yes, no enterococcus
    • anaerobes: yes
    • Other: chlamydia, protozoa
    • excreted thru bile/feces
  16. Metronidazole
    • Bactericidal
    • Anaerobes: yes
    • Other: h.pylori, garnerella, protozoa
    • CSF, placenta
    • hepatic metab
  17. Quinolones
    ciprofloxacin
    levofloxacin
    moxifloxacin
    gemifloxacin
    • Gram + aerobes: Gemi>Moxi>Levo>Cipro
    • Gram - aerobes: yes
    • pseudomonas: Cipro & Levo
    • Anaerobes: Moxi>>Levo, Gemi>Cipro
    • Atypicals: YES
    • Renal elim, except Moxi is hepatic
  18. Aminoglycosides
    tobramycin
    gentamycin
    amikacin
    • Gram + aerobes: in combo regimens
    • Gram - aerobes: yes, including pseudomonas (amikacin>tobra>gent)
    • renal elim
    • amikacin best for pseudomonas, acinetobacter
  19. Natural Penicillins
    • Pen V, Pen G
    • Gram +
    • neisseria
    • anaerobes
  20. Penicillinase resistant penicillins
    • nafcillin, oxacillin, dicloxacillin, cloxacillin
    • Gram +, no entero
  21. Amino penicillins
    • ampicillin, amoxicillin
    • Gram +
    • Gram -, no psuedomonas
    • anaerobes
  22. Carboxy penicillins
    • ticarcillin
    • Gram +, no staph
    • Gram - including pseudomonas
    • anaerobes
  23. Ureido Penicillins
    • piperacillin, mezlocillin
    • Gram +, no staph
    • Gram - including pseudomonas
    • anaerobes
  24. 1st Generation cephalosporins
    • cephalexin, cephalothin, cefazolin
    • Gram +: +++
    • Gram -: + (enteric)
  25. 2nd Generation cephalosporins
    • cefaclor, cefuroxime, cefoxitin
    • Gram +: ++
    • Gram -: ++
    • anerobes: only cephamycins: cefoxitin, cefmetazole, cefotetan
  26. 3rd Generation cephalosporins
    • cefdinir, ceftriaxone, ceftazidime
    • Gram +: +
    • Gram -: +++
    • pseudomonas: ceftazidime
    • ceftriaxone elim in bile
  27. 4th Generation cephalosporins
    • cefepime
    • Gram +: +++
    • Gram -: ++
    • pseudomonas: ++
  28. Carbapenems
    • doripenem, ertapenem, imipenem, meropenem
    • Gram +
    • Gram -, including pseudomonas (not ertapenem)
    • anaerobes
  29. Monobactams
    • aztreonam
    • Gram - only including pseudomonas
  30. Aminoglycosides
    • tobramycin, gentamicin, amikacin
    • Gram - only
    • pseudomonas: amikacin>tobra>gent
    • acinetobacter: amikacin
  31. Quinolones
    • ciprofloxacin, levofloxacin, moxifloxacin, gemifloxacin
    • Gram +, no entero (gemi>moxi>levo>cipro)
    • Gram -
    • pseudomonas (levo, cipro)
    • anaerobes: moxi>>levo, gemi>cipro
  32. Macrolides, ketolides
    • erythromycin, azithromycin, clarithromycin, telithromycin
    • Gram +, meh entero
    • Gram - , enteric
    • Atypicals
    • others: h.pylori,
  33. Lincosamides
    • clindamycin
    • Gram +, no entero...some MRSA
    • anaerobes
    • atypicals: chlamydia, protozoa
  34. Nitromidazole
    • metronidazole
    • anaerobes
    • other: h.pylori, gardnerella, protozoa (anaerobic)
  35. Pseudomonas drugs
    • ticarcillin/clavulanate, piperacillin/tazobactam, mezlocillin
    • ceftazidime
    • cefepime
    • imipenem, meropenem, doripenem
    • amikacin>tobramycin>gentamycin
    • ciprofloxacin, levofloxacin
  36. Drugs for atypicals
    legionella, chlamidia, mycoplasma
    • quinolones
    • macrolides/ketolides
  37. Drugs for anaerobes
    • Clindamycin and Metronidazole
    • natural penicillins
    • amino, ureido, carboxy penicillins
    • cephamycins
    • carbapenems
    • quinolones (moxi more so)
  38. MRSA drugs
    clindamycin

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