ABSITe chapter 14 wound healing.txt

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ABSITe chapter 14 wound healing.txt
2010-01-11 11:08:15
wound healing ABSITE

ABSITE ch 14 wound healing
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  1. Wound healing phase characterized by PMN�s and macrophages, lasting day 1-10 post-insult
  2. Wound healing phase characterized by fibroblasts, collagen production, and granulation tissue, lasting 5days-3weeks post-insult
    Proliferation phase
  3. Wound healing phase characterized by replacement of type III with type I collagen
  4. Order of cell arrival in wound (5 total)
    • Platelets
    • PMNs
    • Macrophages
    • Fibroblasts
    • Lymphocytes
  5. Cells essential for wound healing, that release growth factors and cytokines
  6. Cells that replace fibronectin with collagen
  7. Material that acts as chemotactic for macrophages and anchors fibroblasts
  8. Predominant cell type in wound on day 0-2
  9. Predominant cell type in wound on day 3-4
  10. Predominant cell type in wound on day 5+
  11. Platelets + fibrin
    Platelet plug
  12. Platelets + fibrin + fibronectin
    Provisional matrix
  13. Platelet granules that cause aggregation
    Platelet factor 4
  14. Platelet granules that bind thrombin
  15. Platelet chemoattractant
  16. Platelet aggregation factors (3)
    TXA2, thrombin, platelet factor 4
  17. Vasodilators released from platelets (2)
    PGE2 and PGI1
  18. Most important factor in healing open wounds
    Epithelial integrity
  19. Most important factor in healing cloased incisions
    Tensile strength
  20. Strength layer of bowel
  21. Weakest time point for small bowel anastamosis
    3-5 days
  22. cells involved in wound contraction and healing by secondary intention
  23. most common type of collagen; skin, bone and tendons
    type I
  24. collagen type found in basement membranes
    type IV
  25. collagen type increased in healing wounds, blood vessels and skin
    type III
  26. collagen type found in cartilate
    type II
  27. co-factors required for hydroxylation and cross-linking of protein and collagen formation (4)
    alpha-ketoglutarate, vitamin C, oxygen, and iron
  28. point where a wound reaches maximal tensile strength
    8 weeks
  29. point where a wound is at 80% of final strength and 60% of original strength
    6 weeks
  30. drug that inhibits collagen cross-linking
  31. point in wound healing where type III collagen is replaced by type I
    3 weeks
  32. essentials for wound healing (4)
    moisture, oxygen, no edema, no necrotic tissue
  33. impediments to wound healing (7)
    bacteria >10^5, devitalized tissue, foreign bodies, cytotoxic drugs, diabetes, low albumin, steroids
  34. counteracts effects of steroids on wound healing
    Vitamin A
  35. Cytotoxic drugs that impair wound healing (4)
    5FU, methotrexate, cyclosporine, FK-506
  36. disorder with a type I collagen defect
    osteogenesis imperfecta
  37. collagen disorders creating hyperelastic defects
    Ehlers-Danlos syndrome
  38. Disorder in fibrillin collagen creation
  39. Disorder of excess fibroblast production
    Epidermolysis bullosa
  40. Treatment of epidermolysis bullosa
  41. Cause of 90% of leg ulcers
    Venous insufficiency
  42. Predominant makeup of scar tissue (3)
    Proteoglycans, hyaluronic acid, water
  43. Tissue type containing no blood vessels
  44. Wound healing disorder where collagen goes beyond the original scar
  45. Treatment of keloids
    XRT, steroids, silicone, pressure garments
  46. Wound healing disorder where collagen stays within the confines of the scar
    Hypertrophic scar tissue
  47. Treatment of hypertrophic scar tissue
    Steroids, silicone, pressure garments