neoplasia ch12.txt

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alshada
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3420
Filename:
neoplasia ch12.txt
Updated:
2010-01-11 11:07:49
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neoplasia ABSITE
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ABSITE ch 12 neoplasia
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  1. #2 cause of death in the US
    cancer
  2. molecule that PET scans detect
    fluorodeoxyglucose
  3. lymphocytes that can attack tumor cells independent of antigens
    NK cells
  4. Lymphocytes that need antigen/MHC complex to attack tumor
    T cells
  5. Replacement of one tissue with another (GERD squamous epithelium to columnar gastric tissue)
    Metaplasia
  6. Altered size, shape, and organization of cells (Barretts)
    Dysplasia
  7. Tumor marker for colon ca
    CEA
  8. Tumor marker for liver Ca
    AFP
  9. Tumor marker for pancreatic cancer
    CA 19-9
  10. Tumor marker for ovarian ca
    CA 125
  11. Tumor marker for prostate cancer
    PSA
  12. Tumor marker for small cell lung ca and neuroblastoma
    NSE
  13. Tumor marker for breast cancer
    BRCA 1 and 2
  14. Half life of CEA
    18 days
  15. half life of PSA
    18 days
  16. half life of AFP
    5 days
  17. time between exposure and formation of clinically detectable tumor
    latency period
  18. act of carcinogen interacting with DNA
    initiation
  19. causes of neoplasms (3)
    carcinogenesis, viruses, immunodeficiency
  20. human genes with malignant potential
    proto-oncogenes
  21. most vulnerable stage of cell cycle for XRT
    M phase
  22. Main damage target of oxygen radicals
    DNA
  23. Reasons to use fractionated radiation doses (3)
    Allows repair of normal cells, reoxygenation of tumor, and redistribution of tumor cells in the cell cycle
  24. Most radiosensitive tumors (2)
    Seminomas, lymphomas
  25. Least radiosensitive tumors (2)
    Epithelial, sarcoma
  26. Organs with highest sensitivity to XRT (4)
    Kidneys, lungs, liver, lymphocytes
  27. Source of radiation in or next to tumor (Au 198, I-128); delivers high concentrated doses
    Brachytherapy
  28. Cell cycle-specific agents (2)
    5FU, methotrexate
  29. agents that exhibit plateau in cell-killing ability
    cell cycle-specific agents
  30. agents with a linear response to cell killing
    cell cycle-nonspecific agents
  31. risk of blood clots in tamoxifen
    1%
  32. risk of endometrial cancer in tamoxifen
    1%
  33. chemotherapy that promotes microtubule function and stabilization, causing cell rupture
    taxol
  34. chemotherapy that causes pulmonary fibrosis (2)
    bleomycin, busulfan
  35. toxicities of cisplatin (3)
    nephrotoxic, neurotoxic, ototoxic
  36. toxicities of carboplatin (1)
    myelosuppression
  37. toxicities of vincristine (1)
    neurotoxic (peripheral neuropathy)
  38. toxicities of vinblastine (1)
    myeloid suppression
  39. chemotherapy type that transfers alkyl groups to form covalent bonds
    alkylating agents
  40. alkylating agents (2)
    cyclophosphamide, isofosfamide
  41. anthelminthic drug thought to stimulate immune system against cancer
    levamisole
  42. chemotherapy that inhibits dihydrofolate reductase, which inhibits purine and DNA synthesis
    methotrexate
  43. method of decreasing folate to reverse effect of methotrexate
    leukovorin rescue
  44. DNA intercalator causing O2 radical formation
    Doxorubicin
  45. Chemotherapeutic that inhibits topoisomerase
    Etoposide (VP16)
  46. Chemotherapeutics causing least myelosuppression (4)
    Bleomycin, vincristine, busulfan, cisplatin
  47. Drug used for neutrophil recovery after chemo
    GCSF
  48. Instances where a normal organ is resected to prevent cancer (3)
    Colon (FAP), breast (BRCA1/2), thyroid (RET or MEN 2a)
  49. Tumor suppressor gene on chromosome 13 involved in the cell cycle
    Retinoblastoma
  50. Tumor suppressor on chromosome 17 involved in apoptosis
    P53
  51. Tumor suppressor on chromosome 5, involved with cell adhesion and cytoskeleton function
    APC
  52. Tumor suppressor gene on chromosome 18, involved in cell adhesion
    DCC
  53. Proto-oncogene; G protein defect
    Ras
  54. Proto-oncogene; tyrosine kinase defect
    Src
  55. Proto-oncogene; platelet derived growth factor receptor defect
    Sis
  56. Proto-oncogene; EGFR defect
    Erb B
  57. Proto-oncogene family of nuclear factors
    Myc
  58. Defect in p53 gene causing childhood sarcoma, breast ca, brain ca, leukemia, adrenal ca
    Li Fraumeni syndrome
  59. Cancer associated with Ret proto-oncogene
    Medullary thyroid cancer
  60. Genes involved in colon cancer development (4)
    APC, p53, DCC, K-ras
  61. Carcinogen causing laryngeal, skin, and bronchial cancer
    Coal tar
  62. Carcinogen causing urinary cancer
    Beta-naphthylamine
  63. Carcinogen causing leukemias
    Benzene
  64. Carcinogen causing mesothelioma
    Asbestos
  65. Cancer associated with suspicious supraclavicular nodes (4)
    Breast, stomach, lung, pancreas
  66. Cancer associated with suspicious axillary nodes (3)
    Lymphoma, breast, melanoma
  67. Cancer associated with suspicious periumbilical nodes (1)
    Pancreas
  68. Periumbilical node
    Sister Mary Joseph�s node
  69. Cancer associated with ovarian metastasis
    Stomach (krukenberg), colon
  70. Cancer associated with bone metastasis (2)
    Breast, prostate
  71. Cancer associated with skin metastasis (2)
    Breast, melanoma
  72. Cancer associated with small bowel metastasis (1)
    Melanoma
  73. Tumors amenable to en bloc resection (3)
    Colon, adrenal, gastric
  74. Survival rate of colon ca with liver mets
    25% 5-year
  75. most successfully cured mets with surgery (3)
    colon to liver, sarcoma to lung, melanoma to lung
  76. HIV related malignancies (2)
    Kaposi�s sarcoma, non-Hodgkin�s lymphoma

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