Nurs 281

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Author:
av8girl
ID:
35155
Filename:
Nurs 281
Updated:
2010-09-16 15:27:45
Tags:
Oncology
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Description:
oncology
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  1. RBCs
    • 4-5mil/dl
    • Hgb = 14-18males
    • = 12-16 females
    • Hct 3x normal hgb
  2. WBCs
    • 5000 - 10,000mm3
    • Granulocytes (60-70%)
    • Neutrophils
    • eosinophils
    • basophils

    • Agranulocytes
    • lymphocytes
    • monocytes
  3. Neutrophils
    • immature called band
    • lifespan 1-2 days
    • infection fighting cells
  4. ANC
    • ANC= WBC (%neutrophils + bands)
    • 100
    • ANC= 5500 (8+0) =440
    • 100
  5. Platlets
    • 150,000-400,000
    • Life span 7-10 days
    • <150,000 thrombocytopenia
    • <100,000 hold chemo
    • <40,000 bleeding precautions
    • <10,000 life threatening
  6. Cell Phase
    • G1 - RNA and protein synthesis
    • S - DNA synthesis and replication
    • G2 - DNA synthesis complete and mitotic spendle forms
    • Mitosis - cell division
    • G0 - dormant
  7. Antimetabolites
    "the rebel"
    (think of Obama flicking someone off)
    • Interfere with sysntesis of metabolites (Nucleic acids) necessary for RNA./DNA synthesis
    • Targes cells in S cycle
    • 5-FU or 5-fluorocil
    • Photosensitivity
    • renal toxcity
    • hepatotoxcity
    • NV
    • BMS
  8. Antimitotic Agents
    "the plant based scarecrow name Vin Christine which has neuropathies in it's M shaped legs and diarrhea because it can't go to the toilet"
    • Specific to the M phase by halting mitotic spendle formation
    • Oncovin or Vincristine
    • Neuropathies
    • stomatitis
    • BMS
    • Diarrhea
  9. Alkylating Agents
    Cis Platin and his cousin Plat Inol had alkylin urine because of an infection
    • Alter DNA structure
    • Cell cycle nonspecific
    • Platinol or cisplatin
    • Hemorrhagic cyctitis
    • Renal toxicity
    • ototoxicity
    • NV
    • BMS

    • Must fill out worksheet to figure out creatinine clearance prior to giving dose.
    • hypersensitivity after 7th cycle
  10. Nitrosureas
    The nitrosureas dinosaure named Carmustine ran fast and got blood pumping to his brain
    • Croses the Blood Brain Barrier (lipid soluble)
    • Cell cycle nonspecific
    • Carmustine
    • delayed bms
    • NV
  11. Antitumor Antibotics
    The red devil who messes with your heart - you can only stand so much of him in one lifetime
    • Interfere with DNA synthesis
    • Cell cycle nonspecific
    • Lifetime max dose
    • Doxorubicin andriamycin
    • IV fluid is RED
    • Cardiac toxicity
    • alopeci
    • anorexia
    • BMS
    • NV
  12. Topoisomerase Inhibitors
    while at Camp tosar, I ran to the can (irinotecan) after breathing poison oak smoke and having pulmonary edema and anaphylaxis
    • Topoisomerase is an exzyme needed for DNA synthesis so this drug inhibits this enzyme
    • Camptosar irinotecan
    • Diarrhea
    • allergic reactions - anaphylaxis
    • pulmonary edema
    • NV
    • BMS
    • alopecia

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